3-IODOBENZYL-GUANIDINE HEMISULFATE
- Product Name
- 3-IODOBENZYL-GUANIDINE HEMISULFATE
- CAS No.
- 87862-25-7
- Chemical Name
- 3-IODOBENZYL-GUANIDINE HEMISULFATE
- Synonyms
- M-IBG;MIBG sulfate;MIBG hemisulfate;MIBG HEMISULFATE SALT;Iobenguane sulfate CRS;Iobenguane Hemisulfate;Nafamostat Impurity 14;m-iodobenzylguanidine sulfate;M-IODOBENZYLGUANIDINE 1/2H2SO4;3-IODOBENZYL-GUANIDINE HEMISULFATE
- CBNumber
- CB8278137
- Molecular Formula
- C16H22I2N6O4S
- Formula Weight
- 648.26
- MOL File
- 87862-25-7.mol
3-IODOBENZYL-GUANIDINE HEMISULFATE Property
- storage temp.
- 2-8°C
- solubility
- DMSO: 2 mg/ml; DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml
- form
- A crystalline solid
- color
- White to off-white
Safety
- WGK Germany
- 3
- HS Code
- 2909309090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- I9890
- Product name
- m-Iodobenzylguanidine hemisulfate salt
- Purity
- ≥98%(HPLCandTLC)
- Packaging
- 5mg
- Price
- $148
- Updated
- 2024/03/01
- Product number
- I9890
- Product name
- m-Iodobenzylguanidine hemisulfate salt
- Purity
- ≥98% (HPLC and TLC)
- Packaging
- 25MG
- Price
- $301.8
- Updated
- 2024/03/01
- Product number
- I0328000
- Product name
- Iobenguane sulfate
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- I0328000
- Price
- $220
- Updated
- 2024/03/01
- Product number
- 19998
- Product name
- m-Iodobenzylguanidine (hemisulfate)
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 19998
- Product name
- m-Iodobenzylguanidine (hemisulfate)
- Packaging
- 5mg
- Price
- $93
- Updated
- 2024/03/01
3-IODOBENZYL-GUANIDINE HEMISULFATE Chemical Properties,Usage,Production
Description
m-Iodobenzylguanidine (MIBG) is an analogue of norepinephrine with anticancer activity. It inhibits cell growth in a panel of human and mouse leukemia, fibrosarcoma, melanoma, and neuroblastoma cell lines when used at a concentration of 20 μg/ml and reduces clonogenic survival of L1210 leukemia cells in a concentration-dependent manner. MIBG increases survival in N1E155 and L1210 mouse xenograft models when administered at doses of 40 and 20 mg/kg, respectively. It selectively accumulates in chromaffin tissues and tumors and formulations containing radiolabeled forms of MIBG have been used as imaging agents in the diagnosis and treatment of neuroendocrine tumors. MIBG also inhibits ADP-ribose linkage to membrane proteins in turkey erythrocyte membranes.
Chemical Properties
Colourless to off-white solid
Uses
m-Iodobenzylguanidine Hemisulfate?can be used to demethylate and oxidize membrane-associated DNA. It has also been employed to develop a cell-based high-throughput screening assay to identify anti-hepatitis C virus compounds.
Biochem/physiol Actions
Antitumor agent which inhibits ADP ribosylation.