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1-(1-bromoethyl)-4-fluorobenzene

Product Name
1-(1-bromoethyl)-4-fluorobenzene
CAS No.
65130-46-3
Chemical Name
1-(1-bromoethyl)-4-fluorobenzene
Synonyms
1-(1-Bromoethyl);-4-fluorobenzene;4-FLUOROPHENETHYL BROMIDE;2-(4-FLUOROPHENYL)ETHYL BROMIDE;1-(4-Fluorophenyl)ethyl bromide;1-(1-Bromoethyl)-4-fluorobenzene;1-BROMO-2-(4-FLUOROPHENYL)ETHANE;1-FLUORO-4-(2-BROMOETHYL)BENZENE;4-FLUORO-1-(2-BROMOETHYL)BENZENE;1-Bromo-1-(4-fluorophenyl)ethane
CBNumber
CB8280260
Molecular Formula
C8H8BrF
Formula Weight
203.05
MOL File
65130-46-3.mol
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1-(1-bromoethyl)-4-fluorobenzene Property

Boiling point:
100-104 °C15 mm Hg(lit.)
Density 
1.4498 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.534(lit.)
Flash point:
200 °F
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
form 
oil
color 
Colourless
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Safety

Hazard Codes 
Xn,N
Risk Statements 
22-51/53
Safety Statements 
61
WGK Germany 
2
Hazard Note 
Harmful
HS Code 
2903998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
B997355
Product name
1-(1-Bromoethyl)-4-fluorobenzene
Packaging
100mg
Price
$75
Updated
2021/12/16
SynQuest Laboratories
Product number
1700-B-95
Product name
1-Bromo-1-(4-fluorophenyl)ethane
Purity
98%
Packaging
1g
Price
$20
Updated
2021/12/16
SynQuest Laboratories
Product number
1700-B-95
Product name
1-Bromo-1-(4-fluorophenyl)ethane
Purity
98%
Packaging
5G
Price
$45
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB102294
Product name
1-(1-Bromoethyl)-4-fluorobenzene
Packaging
500mg
Price
$50
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB102294
Product name
1-(1-Bromoethyl)-4-fluorobenzene
Packaging
1g
Price
$80
Updated
2021/12/16
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1-(1-bromoethyl)-4-fluorobenzene Chemical Properties,Usage,Production

Synthesis

403-41-8

65130-46-3

General procedure for the synthesis of 1-(1-bromoethyl)-4-fluorobenzene from 1-(4-fluorophenyl)-1-ethanol: 1-(4-fluorophenyl)ethanol (0.455 mL, 3.57 mmol) was mixed with phosphorus tribromide (0.673 mL, 7.13 mmol) in chloroform (10 mL) and heated to a temperature of 70°C for 3 days. Upon completion of the reaction, the reaction mixture was quenched by pouring it into ice water and diluted with ethyl acetate. The organic layer was separated, washed sequentially with water and brine, dried over anhydrous sodium sulfate and concentrated in vacuum to obtain the crude product. The crude product was purified by silica gel column chromatography with hexane/dichloromethane (2:1) as eluent to afford 1-(1-bromoethyl)-4-fluorobenzene (154 mg, 0.758 mmol, 21.3% yield) as a colorless oil.1H NMR (400 MHz, CDCl3) δ 7.49-7.40 (m, 2H), 7.09-7.00 (m , 2H), 5.23 (q, J = 7.0 Hz, 1H), 2.06 (d, J = 6.8 Hz, 3H).

References

[1] Journal of the American Chemical Society, 2016, vol. 138, # 34, p. 10774 - 10777
[2] Patent: US2012/46301, 2012, A1. Location in patent: Page/Page column 30; 31
[3] Patent: WO2018/148626, 2018, A1. Location in patent: Page/Page column 152
[4] Tetrahedron, 1977, vol. 33, p. 1581 - 1585
[5] Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical & Analytical, 1984, vol. 23, # 1, p. 60 - 62

1-(1-bromoethyl)-4-fluorobenzene Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(1-bromoethyl)-4-fluorobenzene Suppliers

China 53 Germany 1 India 4 Italy 1 United Kingdom 7 United States 7 Global 73
Avra Synthesis Pvt Ltd
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65130-46-3, 1-(1-bromoethyl)-4-fluorobenzeneRelated Search:

(2-Bromoethyl)benzene 1-(2-BROMOETHYL)-3-FLUOROBENZENE N1-(2-BROMOETHYL)-4-FLUOROBENZENE-1-SULPHONAMIDE N1-(2-BROMOETHYL)-4-FLUOROBENZENE-1-SULFONAMIDE 1-(2-BROMOETHYL)-4-FLUOROBENZENE,1-(2-Bromoethyl)-4-fluoroBenzene,4-FluorophenethylBromide

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