ChemicalBook > CAS DataBase List > PPACK, DIHYDROCHLORIDE

PPACK, DIHYDROCHLORIDE

Product Name
PPACK, DIHYDROCHLORIDE
CAS No.
142036-63-3
Chemical Name
PPACK, DIHYDROCHLORIDE
Synonyms
PPACK, DiHCl;D-Phe-Pro-Arg-CMK.HCl;PPACK TRIFLUOROACETATE;PPACK, DIHYDROCHLORIDE;PPACK monohydrochloride;H-D-PHE-PRO-ARG-CMK 2HCL;PPACK, DIHYDROCHLORIDE USP/EP/BP;H-D-PHE-PRO-ARG-CHLOROMETHYLKETONE TFA;H-D-PHE-PRO-ARG-CHLOROMETHYLKETONE 2HCL;PPACK DIHYDROCHLORIDE[D-PHE-PRO-ARG-CHLOROMETHYLKETONE, HCL]
CBNumber
CB8280442
Molecular Formula
C21H32Cl2N6O3
Formula Weight
487.43
MOL File
142036-63-3.mol
More
Less

PPACK, DIHYDROCHLORIDE Property

storage temp. 
0-6°C
solubility 
≥49.5 mg/mL in DMSO; ≥32.5 mg/mL in EtOH; ≥37.9 mg/mL in H2O
form 
solid
color 
white
Water Solubility 
water: 100mg/mL
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
520222
Product name
PPACK, Dihydrochloride
Purity
PPACK, Dihydrochloride is an extremely potent and selective irreversible inhibitor of thrombin (K<su
Packaging
5 mg
Price
$297
Updated
2025/07/31
Sigma-Aldrich
Product number
520222
Product name
PPACK, Dihydrochloride
Purity
PPACK, Dihydrochloride is an extremely potent and selective irreversible inhibitor of thrombin (K<su
Packaging
25 mg
Price
$991
Updated
2025/07/31
Sigma-Aldrich
Product number
520222
Product name
PPACK, Dihydrochloride - CAS 142036-63-3 - Calbiochem
Packaging
5mg
Price
$289
Updated
2024/03/01
Sigma-Aldrich
Product number
520222
Product name
PPACK, Dihydrochloride - CAS 142036-63-3 - Calbiochem
Packaging
25mg
Price
$964
Updated
2024/03/01
Usbiological
Product number
P5504-80
Product name
PPACK Dihydrochloride
Packaging
5mg
Price
$409
Updated
2021/12/16
More
Less

PPACK, DIHYDROCHLORIDE Chemical Properties,Usage,Production

Biological Activity

ppack dihydrochloride is the dihydrochloride form of its active component ppack (d-phenylalanyl-l-prolyl-l-arginine chloromethyl ketone), a potent, selective and irreversible inhibitor of thrombin that inhibits human α-thrombin with inhibition constant kivalue of 0.24 nm. ppack covalently binds to the specific active-site ser of thrombin and cross links with his57 at the binding site forming a tetrahedral ppack-thrombin complex. the complex further binds to and saturates the high-affinity functional thrombin receptors eventually leading to the inhibition of thrombin activation. ppack is currently being investigated as an anti-coagulant to prevent blood coagulation. study results show that ppack is able to dose-dependently inhibit thrombin-induced platelet accumulation.jun t. liu, william paul, michael emerson, carla cicala and clive p. page. thrombin inhibitors and anti-coagulants on thrombin-induced embolization in rabbit cranial vasculature. european journal of pharmacology 264 (1994) 183-190ildiko m. kovach, paul kelley, carol eddy, frank jordan and ahmet baykal. proton bridging in the interactions of thrombin with small inhibitors. biochemistry. 2009; 48(30): 7296-7304martha e. lyon, james s. fine, paul j. henderson and andrew w. lyon. d-phenylalanyl-l-prolyl-l-arginine chloromethyl ketone (ppack): alternative anticoagulant to heparin salts for blood gas and electrolyte specimens. clin. chem. 41/7, 1038-1041 (1995)

PPACK, DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

PPACK, DIHYDROCHLORIDE Suppliers

China 37 Japan 1 Switzerland 2 United Kingdom 1 United States 5 Global 46
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9125
Advantage
58
Hangzhou Peptidego Biotech Co.,Ltd.
Tel
0571-87213919
Email
Eric@peptidego.com
Country
China
ProdList
7408
Advantage
58
Zhejiang J&C Biological Technology Co.,Limited
Tel
+1-2135480471
Email
sales@sarms4muscle.com
Country
China
ProdList
10473
Advantage
58
Dideu Industries Group Limited
Tel
+86-29-89586680 +86-15129568250
Email
1026@dideu.com
Country
China
ProdList
20284
Advantage
58
DONBOO AMINO ACID COMPANY
Tel
+8618051385538
Email
donboo@donboo.com
Country
China
ProdList
9363
Advantage
58
Hubei Xinkang Pharmaceutical Chemical Co., Ltd
Tel
027-027-59308705 18871579363
Fax
027-59308705
Email
1248680011@qq.com
Country
China
ProdList
9849
Advantage
58
Hubei Chenghai Chemical Co., Ltd
Tel
027-59220433 18327245847
Email
1400838877@qq.com
Country
China
ProdList
9875
Advantage
58
Hangzhou Beiputai Biopharmaceutical Co., Ltd
Tel
0571-85350119 15888826472
Email
bptsales@163.com
Country
China
ProdList
3834
Advantage
58
Merck KGaA
Tel
21-20338288
Email
ordercn@merckgroup.com
Country
China
ProdList
6394
Advantage
58
Biosynth Biological Technology (Suzhou) Co Ltd
Tel
51288865780
Email
sales@biosynth.com
Country
China
ProdList
6051
Advantage
58
Santa Cruz Biotechnology Inc
Tel
021-60936350
Email
scbt@scbt.com
Country
China
ProdList
6594
Advantage
58
HANGZHOU LEAP CHEM CO., LTD.
Tel
+86-571-87711850
Email
market18@leapchem.com
Country
China
ProdList
43339
Advantage
58
Nanjing Meisi Biotechnology Co., Ltd.
Tel
18118807185
Country
CHINA
ProdList
124
Advantage
58
Absin Bioscience Inc.
Tel
--
Fax
--
Email
chenjw@absin.cn
Country
CHINA
ProdList
6208
Advantage
58
Beijing Luyuan Bird Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
15810802415@139.com
Country
CHINA
ProdList
6750
Advantage
58
Beijing Taize Jiaye Technology Development Co., Ltd.
Tel
--
Fax
--
Country
CHINA
ProdList
6050
Advantage
58
Beijing Dongge Boye Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
1861586486@qq.com
Country
CHINA
ProdList
6648
Advantage
58
Shanghai Haoran Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
470003480@QQ.COM
Country
CHINA
ProdList
6955
Advantage
58
Hangzhou Lianke Biotechnology Co., Ltd.
Tel
--
Fax
--
Country
CHINA
ProdList
6349
Advantage
58
Shanghai Yijie Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
SHYIJIEBIO@126.COM
Country
CHINA
ProdList
3510
Advantage
58
Beijing Chief-East Tech Co.,Ltd (Qwbio)
Tel
--
Fax
--
Email
info@qwbio.com
Country
China
ProdList
6912
Advantage
50
Beijing Dakco is Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
bj_info@dakewe.net
Country
CHINA
ProdList
6580
Advantage
58
Beijing Anbiqi Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
info@abace-biology.com
Country
CHINA
ProdList
2529
Advantage
58
Shanghai Weiwei Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
tech@chinabiovision.com
Country
CHINA
ProdList
2731
Advantage
58
Beijing Taize Ruida Technology Co., Ltd.
Tel
--
Fax
--
Email
taizeorder@163.com
Country
CHINA
ProdList
6536
Advantage
58
Qiyi Biotechnology (Shanghai) Co., Ltd.
Tel
--
Fax
--
Email
qiyibio@163.com
Country
CHINA
ProdList
6241
Advantage
58
Beijing Zhijie Fangyuan Technology Co., Ltd.
Tel
--
Fax
--
Email
15810200961@163.com
Country
CHINA
ProdList
6643
Advantage
58
Shenzhen Branch Science and Technology Co., Ltd.
Tel
--
Fax
--
Email
zikerbio@163.com
Country
CHINA
ProdList
6374
Advantage
58
Xiamen Research Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
1562893815@qq.com
Country
CHINA
ProdList
6936
Advantage
58
Shanghai Chaoyan Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
471161314@qq.com
Country
CHINA
ProdList
6210
Advantage
58
Beijing Bi Orange Blue Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
bo49855987@163.com
Country
CHINA
ProdList
6827
Advantage
58
Guangzhou Weijia Technology Co., Ltd.
Tel
--
Fax
--
Email
WHIGA22@126.COM
Country
CHINA
ProdList
6757
Advantage
58
Beijing Shengke Boyuan Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
978560024@qq.com
Country
CHINA
ProdList
6458
Advantage
58
Heqi Biotechnology (Shanghai) Co., Ltd.
Tel
--
Fax
--
Email
wcs1978@163.com
Country
CHINA
ProdList
45
Advantage
58
Shenzhen Xinbosheng Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
service@neobioscience.com
Country
CHINA
ProdList
6151
Advantage
58
Beijing Huaxia Ocean Technology Co., Ltd.
Tel
--
Fax
--
Email
huaxiabio@163.com
Country
CHINA
ProdList
6122
Advantage
58
Shanghai Ziqi Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
2453006496@qq.com
Country
CHINA
ProdList
6184
Advantage
58

142036-63-3, PPACK, DIHYDROCHLORIDERelated Search:

1-(2-Aminoethyl)pyrrolidine (S)-2-Aminobutyramide hydrochloride 3-Chloropropylamine hydrochloride (2R)-2-Aminopropanamide hydrochloride Mafenide hydrochloride (R)-(+)-1,2-Diaminopropane dihydrochloride CHEMBRDG-BB 4100050 2-PYRROLIDINOETHYLAMINE 2HCL 1-CHLOROBUTANONE H-PRO-NHET HCL DTYR-PRO-ARG-CHLOROMETHYLKETONE (S)-(+)-2-(AMINOMETHYL)PYRROLIDINE N1,N1-DIETHYLETHANE-1,2-DIAMINE DIHYDROCHLORIDE H-NVA-NH2 HCL (R)-(-)-2-AMINOBUTANAMIDE HYDROCHLORIDE, 97% 1-AMINO-4-GUANIDINOBUTANE 2HCL 2-Pyrrolidinecarboxamide,(S)- 2-Pyrrolidinecarboxamide,N-propyl-,(2S)-(9CI)

  • PPACK, DIHYDROCHLORIDE
  • PPACK TRIFLUOROACETATE
  • H-D-PHE-PRO-ARG-CHLOROMETHYLKETONE 2HCL
  • H-D-PHE-PRO-ARG-CHLOROMETHYLKETONE TFA
  • H-D-PHE-PRO-ARG-CMK 2HCL
  • PPACK, DiHCl
  • PPACK DIHYDROCHLORIDE[D-PHE-PRO-ARG-CHLOROMETHYLKETONE, HCL]
  • D-Phe-Pro-Arg-CMK.HCl
  • PPACK, DIHYDROCHLORIDE USP/EP/BP
  • PPACK monohydrochloride
  • 142036-63-3
  • C21H33N8O3Cl
  • ProteaseInhibitors