PPACK, DIHYDROCHLORIDE

Product Name: PPACK, DIHYDROCHLORIDE
CAS No.: 142036-63-3
Chemical Name: PPACK, DIHYDROCHLORIDE
Synonyms: PPACK, DiHCl;D-Phe-Pro-Arg-CMK.HCl;PPACK TRIFLUOROACETATE;PPACK, DIHYDROCHLORIDE;H-D-PHE-PRO-ARG-CMK 2HCL;PPACK, DIHYDROCHLORIDE USP/EP/BP;H-D-PHE-PRO-ARG-CHLOROMETHYLKETONE TFA;H-D-PHE-PRO-ARG-CHLOROMETHYLKETONE 2HCL;PPACK DIHYDROCHLORIDE[D-PHE-PRO-ARG-CHLOROMETHYLKETONE, HCL]
CBNumber: CB8280442
Molecular Formula: C21H32Cl2N6O3
Formula Weight: 487.43
MOL File: 142036-63-3.mol

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PPACK, DIHYDROCHLORIDE Property

storage temp.: 0-6°C
solubility: ≥49.5 mg/mL in DMSO; ≥32.5 mg/mL in EtOH; ≥37.9 mg/mL in H2O

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 520222
Product name: PPACK, Dihydrochloride - CAS 142036-63-3 - Calbiochem
Packaging: 5mg
Price: $289
Updated: 2024/03/01

Sigma-Aldrich

Product number: 520222
Product name: PPACK, Dihydrochloride - CAS 142036-63-3 - Calbiochem
Packaging: 25mg
Price: $964
Updated: 2024/03/01

Usbiological

Product number: P5504-80
Product name: PPACK Dihydrochloride
Packaging: 5mg
Price: $409
Updated: 2021/12/16

ApexBio Technology

Product number: A2588
Product name: PPACKDihydrochloride
Packaging: 5mg
Price: $263
Updated: 2021/12/16

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PPACK, DIHYDROCHLORIDE Chemical Properties,Usage,Production

Biological Activity

ppack dihydrochloride is the dihydrochloride form of its active component ppack (d-phenylalanyl-l-prolyl-l-arginine chloromethyl ketone), a potent, selective and irreversible inhibitor of thrombin that inhibits human α-thrombin with inhibition constant kivalue of 0.24 nm. ppack covalently binds to the specific active-site ser of thrombin and cross links with his57 at the binding site forming a tetrahedral ppack-thrombin complex. the complex further binds to and saturates the high-affinity functional thrombin receptors eventually leading to the inhibition of thrombin activation. ppack is currently being investigated as an anti-coagulant to prevent blood coagulation. study results show that ppack is able to dose-dependently inhibit thrombin-induced platelet accumulation.jun t. liu, william paul, michael emerson, carla cicala and clive p. page. thrombin inhibitors and anti-coagulants on thrombin-induced embolization in rabbit cranial vasculature. european journal of pharmacology 264 (1994) 183-190ildiko m. kovach, paul kelley, carol eddy, frank jordan and ahmet baykal. proton bridging in the interactions of thrombin with small inhibitors. biochemistry. 2009; 48(30): 7296-7304martha e. lyon, james s. fine, paul j. henderson and andrew w. lyon. d-phenylalanyl-l-prolyl-l-arginine chloromethyl ketone (ppack): alternative anticoagulant to heparin salts for blood gas and electrolyte specimens. clin. chem. 41/7, 1038-1041 (1995)

PPACK, DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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PPACK, DIHYDROCHLORIDE Suppliers

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142036-63-3, PPACK, DIHYDROCHLORIDERelated Search:

1-(2-Aminoethyl)pyrrolidine (S)-2-Aminobutyramide hydrochloride 3-Chloropropylamine hydrochloride (2R)-2-Aminopropanamide hydrochloride Mafenide hydrochloride (R)-(+)-1,2-Diaminopropane dihydrochloride CHEMBRDG-BB 4100050 2-PYRROLIDINOETHYLAMINE 2HCL 1-CHLOROBUTANONE H-PRO-NHET HCL DTYR-PRO-ARG-CHLOROMETHYLKETONE (S)-(+)-2-(AMINOMETHYL)PYRROLIDINE N1,N1-DIETHYLETHANE-1,2-DIAMINE DIHYDROCHLORIDE H-NVA-NH2 HCL (R)-(-)-2-AMINOBUTANAMIDE HYDROCHLORIDE, 97% 1-AMINO-4-GUANIDINOBUTANE 2HCL 2-Pyrrolidinecarboxamide,(S)- 2-Pyrrolidinecarboxamide,N-propyl-,(2S)-(9CI)

PPACK, DIHYDROCHLORIDE

PPACK TRIFLUOROACETATE

H-D-PHE-PRO-ARG-CHLOROMETHYLKETONE 2HCL

H-D-PHE-PRO-ARG-CHLOROMETHYLKETONE TFA

H-D-PHE-PRO-ARG-CMK 2HCL

PPACK, DiHCl

PPACK DIHYDROCHLORIDE[D-PHE-PRO-ARG-CHLOROMETHYLKETONE, HCL]

D-Phe-Pro-Arg-CMK.HCl

PPACK, DIHYDROCHLORIDE USP/EP/BP

142036-63-3

C21H33N8O3Cl

ProteaseInhibitors