4-Fluoro-3-nitrophenylboronic acid
- Product Name
- 4-Fluoro-3-nitrophenylboronic acid
- CAS No.
- 352530-22-4
- Chemical Name
- 4-Fluoro-3-nitrophenylboronic acid
- Synonyms
- 4-Fluoro-3-Nitrophenylboronic;5-Borono-2-fluoronitrobenzene;4-FLUORO-3-NITROPHENYLBORONIC ACID;4-fiuoro-3-nitrophenylboronic acid;3-Nitro-4-fluorophenylboronic acid;4-FLUORO-3-NITROBENZENEBORONIC ACID;Boronic acid,B-(4-fluoro-3-nitrophenyl)-;4-Fluoro-3-nitrophenylboronic acid（Contains Varying Amounts Of Anhydride）
- CBNumber
- CB8287092
- Molecular Formula
- C6H5BFNO4
- Formula Weight
- 184.92
- MOL File
- 352530-22-4.mol
4-Fluoro-3-nitrophenylboronic acid Property
- Boiling point:
- 367.0±52.0 °C(Predicted)
- Density
- 1.49±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 7.02±0.10(Predicted)
- Appearance
- Off-white to yellow Solid
- InChI
- InChI=1S/C6H5BFNO4/c8-5-2-1-4(7(10)11)3-6(5)9(12)13/h1-3,10-11H
- InChIKey
- JDPKQZFQCPEJNH-UHFFFAOYSA-N
- SMILES
- B(C1=CC=C(F)C([N+]([O-])=O)=C1)(O)O
- CAS DataBase Reference
- 352530-22-4(CAS DataBase Reference)
Safety
- HS Code
- 2931900090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P363Wash contaminated clothing before reuse.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- F594958
- Product name
- 4-Fluoro-3-nitrophenylboronicacid
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 8660-3-07
- Product name
- 4-Fluoro-3-nitrobenzeneboronic acid
- Packaging
- 250mg
- Price
- $48
- Updated
- 2021/12/16
- Product number
- BOR0001533
- Product name
- 4-FLUORO-3-NITRO PHENYL BORONIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $319.2
- Updated
- 2021/12/16
- Product number
- PC9161
- Product name
- 4-Fluoro-3-nitrobenzeneboronicacid
- Packaging
- 5g
- Price
- $338
- Updated
- 2021/12/16
- Product number
- E821
- Product name
- 4-Fluoro-3-nitrophenylboronicacid
- Packaging
- 5g
- Price
- $441
- Updated
- 2021/12/16
4-Fluoro-3-nitrophenylboronic acid Chemical Properties,Usage,Production
Uses
suzuki reaction
Synthesis
1765-93-1
352530-22-4
General procedure for the synthesis of 4-fluoro-3-nitrophenylboronic acid from 4-fluorophenylboronic acid: fuming nitric acid (140 mL) was added to a 250 mL four-necked flask and cooled in a dry ethanol bath to a temperature of between -35 °C and -45 °C with continuous stirring. Pre-thoroughly dried and pulverized 4-fluorophenylboronic acid (20 g) was slowly added to the flask in batches, ensuring that the reaction temperature was maintained between -35 °C and -45 °C. The reaction temperature was then adjusted to the temperature of the flask. After the addition was completed, the progress of the reaction was monitored by thin layer chromatography (TLC) until the reaction was complete. The reaction mixture was poured into 200 g of crushed ice and stirred rapidly to precipitate a yellow solid, which was subsequently filtered through a Brinell funnel and washed twice with ice water (20 mL) and drained. The pH of the filtrate was adjusted to 6 with sodium bicarbonate solution and then extracted with ethyl acetate. The organic phases were combined, dried with anhydrous magnesium sulfate and concentrated to dryness. Finally, pulping with n-heptane gave the light yellow solid product 4-fluoro-3-nitrophenylboronic acid (8.3 g) in 31.5% yield.
References
[1] Patent: CN103626791, 2016, B. Location in patent: Paragraph 0024; 0029
4-Fluoro-3-nitrophenylboronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Fluoro-3-nitrophenylboronic acid manufacturers
- Product
- 4-Fluoro-3-nitrophenylboronic acid 352530-22-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg; 5kg; 100kg
- Release date
- 2019-07-03