12(R)-HETE

Product Name: 12(R)-HETE
CAS No.: 82337-46-0
Chemical Name: 12(R)-HETE
Synonyms: 12(R)-HETE;12(R)HETE,12(R) HETE;ZNHVWPKMFKADKW-ZYBDYUKJSA-N;12(R)-HETE Lipid Maps MS Standard;(R)-12-Hydroxyeicosatetraenoic acid;12(R)-hydroxy-5(Z),8(Z),10(E),14(Z)-ETA;12R-HYDROXY-5Z,8Z,10E,14Z-EICOSATETRAENOIC ACID;12(R)-HYDROXYEICOSA-5Z,8Z,10E,14Z-TETRAENOIC ACID;12(R)-hydroxy-(5Z,8Z,10E,14Z)-*eicosatetraenoic A;(5Z,8Z,10E,12R,14Z)-12-Hydroxy-5,8,10,14-icosatetraenoic acid
CBNumber: CB8288367
Molecular Formula: C20H32O3
Formula Weight: 320.47
MOL File: 82337-46-0.mol

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12(R)-HETE Property

storage temp.: -20°C
solubility: 0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS pH 7.2: 0.8 mg/ml
form: Liquid
color: Colorless to light yellow

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Safety

Hazard Codes: F,Xi
Risk Statements: 11-36/37/38
Safety Statements: 16-26-36

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 34560
Product name: 12(R)-HETE
Purity: ≥98%
Packaging: 25μg
Price: $141
Updated: 2024/03/01

Cayman Chemical

Product number: 34560
Product name: 12(R)-HETE
Purity: ≥98%
Packaging: 50μg
Price: $267
Updated: 2024/03/01

Cayman Chemical

Product number: 34560
Product name: 12(R)-HETE
Purity: ≥98%
Packaging: 100μg
Price: $392
Updated: 2024/03/01

American Custom Chemicals Corporation

Product number: LIP0000390
Product name: 12R-HYDROXY-5Z,8Z,10E,14Z-EICOSATETRAENOIC ACID
Purity: 95.00%
Packaging: 5MG
Price: $495.21
Updated: 2021/12/16

AHH

Product number: MT-22174
Product name: 12??R??-Hete
Purity: 98%
Packaging: 0.00025g
Price: $638
Updated: 2021/12/16

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12(R)-HETE Chemical Properties,Usage,Production

Uses

12(R)-HETE is a metabolite of Arachidonic acid, AA (HY-109590) and can be found in skin from psoriatic lesions. 12(R)-HETE induces lymphocytes chemotaxis, stimulates calcium mobilization and chemotaxis in neutrophils via the BLT1 receptor, activates the aryl hydrocarbon receptor, and inhibits Na+/K+ ATPase activity in the corneal epithelium[1][2][3][4].

Definition

ChEBI: A HETE having a (12R)-hydroxy group and (5Z)-, (8Z)-, (10E)- and (14Z)-double bonds.

References

[1] Schwartzman ML, et al., 12(R)-hydroxyicosatetraenoic acid: a cytochrome-P450-dependent arachidonate metabolite that inhibits Na+,K+-ATPase in the cornea. Proc Natl Acad Sci U S A. 1987 Nov;84(22):8125-9. DOI:10.1073/pnas.84.22.8125
[2] Bacon KB, et al., Contrasting in vitro lymphocyte chemotactic activity of the hydroxyl enantiomers of 12-hydroxy-5,8,10,14-eicosatetraenoic acid. Br J Pharmacol. 1988 Nov;95(3):966-74. DOI:10.1111/j.1476-5381.1988.tb11727.x
[3] Powell WS, et al., Effects of oxo and dihydro metabolites of 12-hydroxy-5,8,10,14-eicosatetraenoic acid on chemotaxis and cytosolic calcium levels in human neutrophils. J Leukoc Biol. 1995 Feb;57(2):257-63. DOI:10.1002/jlb.57.2.257
[4] Chiaro CR, et al., 12(R)-Hydroxy-5(Z),8(Z),10(E),14(Z)-eicosatetraenoic acid [12(R)-HETE], an arachidonic acid derivative, is an activator of the aryl hydrocarbon receptor. Mol Pharmacol. 2008 Dec;74(6):1649-56. DOI:10.1124/mol.108.049379

12(R)-HETE Preparation Products And Raw materials

Raw materials

Preparation Products

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12(R)-HETE Suppliers

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82337-46-0, 12(R)-HETERelated Search:

CYCLOPIAZONIC ACID Bufalin Thapsigargin 6-Gingerol OLIGOMYCIN A BAFILOMYCIN A1 citreoviridin (+/-)12-HETE 12(R)-HETE

12(R)-hydroxy-(5Z,8Z,10E,14Z)-*eicosatetraenoic A

(5Z,8Z,10E,12R,14Z)-12-hydroxyicosa-5,8,10,14-tetraenoic acid

(5Z,8Z,10E,12R,14Z)-12-Hydroxy-5,8,10,14-icosatetraenoic acid

(R)-12-Hydroxyeicosatetraenoic acid

12(R)-HETE Lipid Maps MS Standard

ZNHVWPKMFKADKW-ZYBDYUKJSA-N

12R-HYDROXY-5Z,8Z,10E,14Z-EICOSATETRAENOIC ACID

12(R)-HYDROXYEICOSA-5Z,8Z,10E,14Z-TETRAENOIC ACID

12(R)-HETE

5,8,10,14-Eicosatetraenoic acid, 12-hydroxy-, (5Z,8Z,10E,12R,14Z)-

12(R)HETE,12(R) HETE

12(R)-hydroxy-5(Z),8(Z),10(E),14(Z)-ETA

82337-46-0