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(+/-)-BUFURALOL HYDROCHLORIDE

Product Name
(+/-)-BUFURALOL HYDROCHLORIDE
CAS No.
59652-29-8
Chemical Name
(+/-)-BUFURALOL HYDROCHLORIDE
Synonyms
ANGIUM;ro3-4787;AngiumHCl;Bufuralol HCl;bufurololhydrochloride;Bufuralol hudrochloride;BUFURALOL, HYDROCHLORIDE;(+/-)-BUFURALOL HYDROCHLORIDE;2-tert-butylamino-1-(7-ethyl-2-benzofuranyl)ethanolhydrochloride;2-tert-butylamino-1-(7-ethyl-2-benzofuranyl)-ethanohydrochloride
CBNumber
CB8289344
Molecular Formula
C16H24ClNO2
Formula Weight
297.82
MOL File
59652-29-8.mol
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(+/-)-BUFURALOL HYDROCHLORIDE Property

Melting point:
143-146 °C
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Sonicated), Water (Slightly)
form 
Solid
color 
white to off-white
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Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
Toxicity
LD50 in mice (mg/kg): 29.7 i.v.; 88.0 i.p.; 177 orally; in rats (mg/kg): 1400 s.c.; 750 orally (Hamilton, Parkes)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Medical Isotopes, Inc.
Product number
7889
Product name
BufuralolHCl
Packaging
50mg
Price
$2000
Updated
2021/12/16
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(+/-)-BUFURALOL HYDROCHLORIDE Chemical Properties,Usage,Production

Chemical Properties

Fine White Powder

Originator

Bururalol hydrochloride,Onbio Inc.

Uses

A -Adrenergic blocker with peripheral vasodilating activity

Uses

A β-Adrenergic blocker with peripheral vasodilating activity. Antianginal; antihypertensive.

Manufacturing Process

68.3 g (0.182 mol) of trimethyl-phenyl-ammonium perbromide were added in a single portion at 20°C to a stirred solution of 48.5 g (0.182 mol) of 5- bromo-2-acetyl-7-ethylbenzofuran in 400 ml of dry tetrahydro-furan. The resulting mixture was stirred at 20°C for 3 h, during which time trimethylphenyl- ammonium bromide precipitated out. The mixture was then poured into water and extracted 3 times with ether. The combined ether extracts were washed successively with water, saturated sodium bicarbonate solution, water and saturated brine, dried over anhydrous sodium sulfate, filtered and evaporated under reduced pressure. The solid residue was recrystallized from ethanol to yield 43.1 g of 5-bromo-2-bromoacetyl-7-ethylbenzofuran as yellow crystals, melting point 101-102°C.
1.35 g of sodium borohydride were added portion-wise at room temperature over a period of 20 min to a stirred solution of 17.3 g (0.05 mol) of 5-bromo- 2-bromoacetyl-7-ethylbenzofuran in 100 ml of dioxane and 25 ml of water.
The mixture was stirred at room temperature for 3 h, then dioxane was removed by evaporation at 40°C under reduced pressure and the residue was diluted with water and extracted 3 times with ether. The combined ether extracts were worked up in the usual manner to yield 16.0 g of crude 5- bromo-2-(2-bromo-1-hydroxyethyl)-7-ethyl-benzofuran as a viscous oil. 16.0 g of crude 5-bromo-2-(2-bromo-1-hydroxyethyl)-7-ethylbenzofuran and 37.0 g of t-butylamine were heated at 100°C in a sealed autoclave for 24 h. After cooling, excess t-butylamine was evaporated off and the residue was taken up in dilute aqueous hydrochloric acid. The aqueous solution was washed twice with ether, basified with dilute aqueous sodium hydroxide solution and extracted twice with ether. The combined ether extracts were washed with water and with brine, dried over anhydrous sodium sulfate, filtered and evaporated. The solid residue was crystallized from petroleum ether (boiling point 60-80°C) to yield 4.7 g of 5-bromo-2-(2-t-butylamino-1- hydroxyethyl)-7-ethylbenzofuran as buff crystals, melting point 101-103°C.
4.8 g of 5-bromo-2-(2-t-butylamino-1-hydroxyethyl)-7-ethylbenzofuran in 50 ml of ethanol were hydrogenated at room temperature and atmospheric pressure in the presence of 0.3 g of 5% palladium-on-carbon catalyst. After the uptake of one equivalent of hydrogen, the hydrogenation was terminated, catalyst was filtered off and the filtrate was evaporated to dryness. The residue was basified and extracted twice with ether. The combined ether extracts were worked up in the usual manner to give 2-(2-t-butylamino-1- hydroxyethyl)-7-ethylbenzofuran in the form of an oil. In practice it is usually used as hydrochloride.

Therapeutic Function

Beta-adrenergic blocker

(+/-)-BUFURALOL HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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(+/-)-BUFURALOL HYDROCHLORIDE Suppliers

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
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69
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
Advantage
60
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57423
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
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58
Guangzhou Dreampharm Biotechnology Co., Ltd.
Tel
020-36607679 17825480238
Fax
QQ 3008233717
Email
3008233746@qq.com
Country
China
ProdList
9919
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12
Jinan blalong chemical co. LTD
Tel
2710913286@.com
Email
1513643261@qq.com
Country
China
ProdList
14246
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58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
Advantage
58
Changzhou Furuisi Biotechnology Co., Ltd
Tel
0519-85524369
Email
3477467573@qq.com
Country
China
ProdList
8617
Advantage
58

59652-29-8, (+/-)-BUFURALOL HYDROCHLORIDERelated Search:


  • 1-(7-aethylbenzofuran-2-yl)-2-tert-butylamino-1-hydroxyaethan-hydrochlorid
  • 1-(7-ethylbenzofuran-2-yl)-2-tert-butylamino-1-hydroxyethanehydrochloride
  • 2-tert-butylamino-1-(7-ethyl-2-benzofuranyl)-ethanohydrochloride
  • 2-tert-butylamino-1-(7-ethyl-2-benzofuranyl)ethanolhydrochloride
  • bufurololhydrochloride
  • ro3-4787
  • ANGIUM
  • (+/-)-BUFURALOL HYDROCHLORIDE
  • BUFURALOL, HYDROCHLORIDE
  • ALPHA-[(TERT-BUTYLAMINO)METHYL]-7-ETHYL-2-BENZOFURANMETHANOL HYDROCHLORIDE
  • AngiumHCl
  • a-[[(1,1-Dimethylethyl)-amino]methyl]-7-ethyl-2-benzofuranmethanol
  • α-[[(1,1-Dimethylethyl)-amino]methyl]-7-ethyl-2-benzofuranmethanol
  • 1-(7-Aethylbenzofuran-2-yl)-2-tert-butylamino-1-hydroxyaethan-hydrochlorid [german]
  • Bufuralol HCl
  • Bufuralol hudrochloride
  • 2-(tert-Butylamino)-1-(7-ethylbenzofuran-2-yl)ethan-1-ol hydrochloride
  • 59652-29-8
  • C16H23NO2HCl
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