AROTINOLOL
- Product Name
- AROTINOLOL
- CAS No.
- 68377-92-4
- Chemical Name
- AROTINOLOL
- Synonyms
- Arot-API;Arotinolo;Arottnolol;AROTINOLOL;NSC 317940;Arotinolol (Almarl);Arotinolol free base;AROTINOLOL USP/EP/BP;5-(2-((3-(tert-Butylamino);Arotinolol Solution, 100ppm
- CBNumber
- CB4486237
- Molecular Formula
- C15H21N3O2S3
- Formula Weight
- 371.54
- MOL File
- 68377-92-4.mol
AROTINOLOL Property
- Melting point:
- 148-149°
- Boiling point:
- 599.8±60.0 °C(Predicted)
- Density
- 1.35
- storage temp.
- 2-8°C(protect from light)
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 13.71±0.20(Predicted)
- form
- Solid
- color
- Off-White to Pale Yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A771500
- Product name
- Arotinolol
- Packaging
- 100mg
- Price
- $185
- Updated
- 2021/12/16
- Product number
- FA41108
- Product name
- Arotinolol
- Packaging
- 25mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- CS-0102757
- Product name
- Arotinolol
- Purity
- 98.18%
- Packaging
- 5mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- K136
- Product name
- Arotinolol
- Packaging
- 5mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- CS-0102757
- Product name
- Arotinolol
- Purity
- 98.18%
- Packaging
- 10mg
- Price
- $150
- Updated
- 2021/12/16
AROTINOLOL Chemical Properties,Usage,Production
Originator
Arotinolol,ZYF Pharm
Uses
Arotinolol is both and alpha- and beta-adrenoceptor antagonist and is used to treat essential tremors and hypertension.
Definition
ChEBI: Arotinolol is a member of thiophenes and an aromatic amide.
Manufacturing Process
To a solution of 2-mercapto-4-(5'-carbamoyl-2'-thiophenyl)thiazole, 3.2 g in
20 ml of 0.3 % aqueous sodium hydroxide solution, 1-chloro-3-tbutylaminopropanol,
12.64 g in 20 ml of methanol was added, while the
temperature was maintained at 20°C.
The reaction solution was stirred at room temperature for 4 h, and then
condensed to a half volume in vacuo. The residual solution, added with 100 ml
of water, was extracted with chloroform. The chloroform extract was washed
with water, dried over anhydrous magnesium sulfate and evaporated in vacuo
to give 4.8 g of 2-(3'-t-butylamino-2'-hydroxypropylthio)-4-(5'-carbamoyl-2'-
thiophenyl)thiazole, as crystals, melting point 234°-235.5°C (dec.,
recrystallized from methanol/water).
In practice it is usually used as hydrochloride.
Therapeutic Function
Beta-adrenergic blocker
AROTINOLOL Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from AROTINOLOL manufacturers
- Product
- Arotinolol 68377-92-4
- Price
- US $200.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000kg/Month
- Release date
- 2022-11-23
- Product
- Arotinolol 68377-92-4
- Price
- US $100.00/KG
- Min. Order
- 25KG
- Purity
- 99%
- Supply Ability
- 1000 Kilogram/Kilograms per Week
- Release date
- 2023-03-10
- Product
- AROTINOLOL 68377-92-4
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-11