AROTINOLOL

ChemicalBook > CAS DataBase List > AROTINOLOL

Product Name: AROTINOLOL
CAS No.: 68377-92-4
Chemical Name: AROTINOLOL
Synonyms: Arot-API;Arotinolo;Arottnolol;AROTINOLOL;NSC 317940;Arotinolol (Almarl);Arotinolol free base;AROTINOLOL USP/EP/BP;5-(2-((3-(tert-Butylamino);Arotinolol Solution, 100ppm
CBNumber: CB4486237
Molecular Formula: C15H21N3O2S3
Formula Weight: 371.54
MOL File: 68377-92-4.mol

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AROTINOLOL Property

Melting point:: 148-149°
Boiling point:: 599.8±60.0 °C(Predicted)
Density: 1.35
storage temp.: 2-8°C(protect from light)
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 13.71±0.20(Predicted)
form: Solid
color: Off-White to Pale Yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: A771500
Product name: Arotinolol
Packaging: 100mg
Price: $185
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA41108
Product name: Arotinolol
Packaging: 25mg
Price: $200
Updated: 2021/12/16

ChemScene

Product number: CS-0102757
Product name: Arotinolol
Purity: 98.18%
Packaging: 5mg
Price: $90
Updated: 2021/12/16

AK Scientific

Product number: K136
Product name: Arotinolol
Packaging: 5mg
Price: $95
Updated: 2021/12/16

ChemScene

Product number: CS-0102757
Product name: Arotinolol
Purity: 98.18%
Packaging: 10mg
Price: $150
Updated: 2021/12/16

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AROTINOLOL Chemical Properties,Usage,Production

Originator

Arotinolol,ZYF Pharm

Uses

Arotinolol is both and alpha- and beta-adrenoceptor antagonist and is used to treat essential tremors and hypertension.

Definition

ChEBI: Arotinolol is a member of thiophenes and an aromatic amide.

Manufacturing Process

To a solution of 2-mercapto-4-(5'-carbamoyl-2'-thiophenyl)thiazole, 3.2 g in 20 ml of 0.3 % aqueous sodium hydroxide solution, 1-chloro-3-tbutylaminopropanol, 12.64 g in 20 ml of methanol was added, while the temperature was maintained at 20°C.
The reaction solution was stirred at room temperature for 4 h, and then condensed to a half volume in vacuo. The residual solution, added with 100 ml of water, was extracted with chloroform. The chloroform extract was washed with water, dried over anhydrous magnesium sulfate and evaporated in vacuo to give 4.8 g of 2-(3'-t-butylamino-2'-hydroxypropylthio)-4-(5'-carbamoyl-2'- thiophenyl)thiazole, as crystals, melting point 234°-235.5°C (dec., recrystallized from methanol/water).
In practice it is usually used as hydrochloride.

Therapeutic Function

Beta-adrenergic blocker

AROTINOLOL Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from AROTINOLOL manufacturers

Career Henan Chemica Co

Product: AROTINOLOL 68377-92-4
Price: US $1.00/g
Min. Order: 1g
Purity: 85.0-99.8%
Supply Ability: 20ton
Release date: 2020-10-28

Hebei Mingeng Biotechnology Co., Ltd

Product: Arotinolol 68377-92-4
Price: US $200.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000kg/Month
Release date: 2022-11-23

Shijiazhuang Gantuo Biotechnology Co., Ltd

Product: Arotinolol 68377-92-4
Price: US $100.00/KG
Min. Order: 25KG
Purity: 99%
Supply Ability: 1000 Kilogram/Kilograms per Week
Release date: 2023-03-10

68377-92-4, AROTINOLOLRelated Search:

Topiramate Vildagliptin Tirofiban Argatroban Bumetanide NADOLOL Pramipexole Amiloride hydrochloride Lercanidipine Acebutolol Bisoprolol Candesartan Gabapentin AROTINOLOL HYDROCHLORIDE,AROTINOLOL HCL (+)-S-Arotinolol (-)-R-Arotinolol S-Arotinolol HCl R-Arotinolol HCl

AROTINOLOL

Arottnolol

2-(3-tert-Butylamino-2-hydroxypropylthio)-4-(5-carbamoyl-2-thienyl)thiazole

2-Thiophenecarboxamide, 5-[2-[[3-[(1,1-dimethylethyl)amino]-2-hydroxypropyl]thio]-4-thiazolyl]-

2-Thiophenecarboxamide, 5-[2-[[3-[(1,1-dimethylethyl)amino]-2-hydroxypropyl]thio]-4-thiazolyl]-, (+-)-

NSC 317940

5-[2-[[3-(tert-butylamino)-2-hydroxy-propyl]thio]thiazol-4-yl]thiophene-2-carboxamide

5-[2-[3-(tert-butylamino)-2-hydroxy-propyl]sulfanyl-1,3-thiazol-4-yl]thiophene-2-carboxamide

5-[2-[3-(tert-butylamino)-2-hydroxypropyl]sulfanyl-1,3-thiazol-4-yl]thiophene-2-carboxamide

5-(2-((3-(tert-Butylamino)

Arotinolol Solution, 1000ppm

Arotinolo

Arotinolol Solution, 100ppm

Arotinolol free base

AROTINOLOL USP/EP/BP

Arotinolol (Almarl)

Arot-API

68377-92-4

C15H21N3O2S3