ChemicalBook > CAS DataBase List > AROTINOLOL

AROTINOLOL

Product Name
AROTINOLOL
CAS No.
68377-92-4
Chemical Name
AROTINOLOL
Synonyms
Arot-API;Arotinolo;Arottnolol;AROTINOLOL;NSC 317940;Arotinolol (Almarl);Arotinolol free base;AROTINOLOL USP/EP/BP;5-(2-((3-(tert-Butylamino);Arotinolol Solution, 100ppm
CBNumber
CB4486237
Molecular Formula
C15H21N3O2S3
Formula Weight
371.54
MOL File
68377-92-4.mol
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AROTINOLOL Property

Melting point:
148-149°
Boiling point:
599.8±60.0 °C(Predicted)
Density 
1.35
storage temp. 
2-8°C(protect from light)
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
13.71±0.20(Predicted)
form 
Solid
color 
Off-White to Pale Yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
A771500
Product name
Arotinolol
Packaging
100mg
Price
$185
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA41108
Product name
Arotinolol
Packaging
25mg
Price
$200
Updated
2021/12/16
ChemScene
Product number
CS-0102757
Product name
Arotinolol
Purity
98.18%
Packaging
5mg
Price
$90
Updated
2021/12/16
AK Scientific
Product number
K136
Product name
Arotinolol
Packaging
5mg
Price
$95
Updated
2021/12/16
ChemScene
Product number
CS-0102757
Product name
Arotinolol
Purity
98.18%
Packaging
10mg
Price
$150
Updated
2021/12/16
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AROTINOLOL Chemical Properties,Usage,Production

Originator

Arotinolol,ZYF Pharm

Uses

Arotinolol is both and alpha- and beta-adrenoceptor antagonist and is used to treat essential tremors and hypertension.

Definition

ChEBI: Arotinolol is a member of thiophenes and an aromatic amide.

Manufacturing Process

To a solution of 2-mercapto-4-(5'-carbamoyl-2'-thiophenyl)thiazole, 3.2 g in 20 ml of 0.3 % aqueous sodium hydroxide solution, 1-chloro-3-tbutylaminopropanol, 12.64 g in 20 ml of methanol was added, while the temperature was maintained at 20°C.
The reaction solution was stirred at room temperature for 4 h, and then condensed to a half volume in vacuo. The residual solution, added with 100 ml of water, was extracted with chloroform. The chloroform extract was washed with water, dried over anhydrous magnesium sulfate and evaporated in vacuo to give 4.8 g of 2-(3'-t-butylamino-2'-hydroxypropylthio)-4-(5'-carbamoyl-2'- thiophenyl)thiazole, as crystals, melting point 234°-235.5°C (dec., recrystallized from methanol/water).
In practice it is usually used as hydrochloride.

Therapeutic Function

Beta-adrenergic blocker

AROTINOLOL Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from AROTINOLOL manufacturers

Hebei Mingeng Biotechnology Co., Ltd
Product
Arotinolol 68377-92-4
Price
US $200.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg/Month
Release date
2022-11-23
Shijiazhuang Gantuo Biotechnology Co., Ltd
Product
Arotinolol 68377-92-4
Price
US $100.00/KG
Min. Order
25KG
Purity
99%
Supply Ability
1000 Kilogram/Kilograms per Week
Release date
2023-03-10
Dideu Industries Group Limited
Product
AROTINOLOL 68377-92-4
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-08-11

68377-92-4, AROTINOLOLRelated Search:

Topiramate Vildagliptin Tirofiban Argatroban Bumetanide NADOLOL Pramipexole Amiloride hydrochloride Lercanidipine Acebutolol Bisoprolol Candesartan Gabapentin AROTINOLOL HYDROCHLORIDE,AROTINOLOL HCL (+)-S-Arotinolol (-)-R-Arotinolol S-Arotinolol HCl R-Arotinolol HCl

  • AROTINOLOL
  • Arottnolol
  • 2-(3-tert-Butylamino-2-hydroxypropylthio)-4-(5-carbamoyl-2-thienyl)thiazole
  • 2-Thiophenecarboxamide, 5-[2-[[3-[(1,1-dimethylethyl)amino]-2-hydroxypropyl]thio]-4-thiazolyl]-
  • 2-Thiophenecarboxamide, 5-[2-[[3-[(1,1-dimethylethyl)amino]-2-hydroxypropyl]thio]-4-thiazolyl]-, (+-)-
  • NSC 317940
  • 5-[2-[[3-(tert-butylamino)-2-hydroxy-propyl]thio]thiazol-4-yl]thiophene-2-carboxamide
  • 5-[2-[3-(tert-butylamino)-2-hydroxy-propyl]sulfanyl-1,3-thiazol-4-yl]thiophene-2-carboxamide
  • 5-[2-[3-(tert-butylamino)-2-hydroxypropyl]sulfanyl-1,3-thiazol-4-yl]thiophene-2-carboxamide
  • 5-(2-((3-(tert-Butylamino)
  • Arotinolol Solution, 1000ppm
  • Arotinolo
  • Arotinolol Solution, 100ppm
  • Arotinolol free base
  • AROTINOLOL USP/EP/BP
  • Arotinolol (Almarl)
  • Arot-API
  • 68377-92-4
  • C15H21N3O2S3