ChemicalBook > CAS DataBase List > 1,10-Phenanthroline hydrate

1,10-Phenanthroline hydrate

Product Name
1,10-Phenanthroline hydrate
CAS No.
5144-89-8
Chemical Name
1,10-Phenanthroline hydrate
Synonyms
1,10-PHENANTHROLINE MONOHYDRATE;ORTHO-PHENANTHROLINE;Phenanthroline Monohydrate;1,10-PHENANTHROLINE H2O;O-PHENANTHROLINE MONOHYDRATE;1,10-Phenanthroline, ACS, 99%;10-Phenanthroline monohydrate;PHENYLANTHROLINE HYDRATE 1,10-;1,10-PHENANTHROLINE AR;Black bone vine extract
CBNumber
CB8290304
Molecular Formula
C12H8N2.H2O
Formula Weight
198.22
MOL File
5144-89-8.mol
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1,10-Phenanthroline hydrate Property

Melting point:
100-104 °C(lit.)
Density 
1.10
vapor density 
6.2 (vs air)
storage temp. 
Sealed in dry,Room Temperature
solubility 
methanol: soluble200MM (Stock solution is stable for months at –20° C.)
form 
Needle-Like Crystals
color 
Off-white, may become cream-colored during storage
Water Solubility 
<0.01 g/100 mL at 21 ºC
Merck 
14,7214
BRN 
4008096
Stability:
Stable. Incompatible with iron, other heavy metals, strong oxidizing agents, strong acids.
CAS DataBase Reference
5144-89-8(CAS DataBase Reference)
EPA Substance Registry System
1,10-Phenanthroline, monohydrate (5144-89-8)
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Safety

Hazard Codes 
T,N
Risk Statements 
25-50/53
Safety Statements 
45-60-61
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
SF8437000
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
III
HS Code 
29339990
Toxicity
LD50 orally in Rabbit: 132 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
77500
Product name
1,10-Phenanthroline monohydrate
Purity
for the spectrophotometric determination of Fe, Pd, V, ≥99.0%
Packaging
5G
Price
$61.4
Updated
2024/03/01
Sigma-Aldrich
Product number
77500
Product name
1,10-Phenanthroline monohydrate
Purity
for the spectrophotometric determination of Fe, Pd, V, ≥99.0%
Packaging
25g
Price
$242
Updated
2024/03/01
Sigma-Aldrich
Product number
320056
Product name
1,10-Phenanthroline monohydrate
Purity
ACS reagent, 99%
Packaging
5g
Price
$70.8
Updated
2024/03/01
Sigma-Aldrich
Product number
320056
Product name
1,10-Phenanthroline monohydrate
Purity
ACS reagent, 99%
Packaging
25g
Price
$209
Updated
2024/03/01
Sigma-Aldrich
Product number
1.07225
Product name
1,10-Phenanthroline monohydrate
Purity
GR ACS
Packaging
10g
Price
$242
Updated
2024/03/01
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1,10-Phenanthroline hydrate Chemical Properties,Usage,Production

Chemical Properties

white crystals or powder

Uses

1,10-Phenanthroline monohydrate is useful to study the DNA-protein interactions due to its nuclease activity. It is used as a redox indicator and reagent for spectrophotometric assay of silver. It acts as a chelating ligand for the determination of Fe, Pd and V. It also acts as a matrix metalloproteinase inhibitor. It is a photometric reagent for iron, which forms a red chelate with ferrous (iron II) ion.

Uses

When complexed with copper, it possesses nuclease activity that has been used to study DNA-protein interactions.
1,10-Phenanthroline monohydrate is an aromatic nitrogen heterocycle that may be used as a chelating agent in the preparation of metal-chelate complexes.

General Description

White crystalline powder or solid. Slight odor.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

1,10-Phenanthroline hydrate is incompatible with strong oxidizers. 1,10-Phenanthroline hydrate is also incompatible with strong acids. 1,10-Phenanthroline hydrate forms complex compounds with ferrous ions. .

Fire Hazard

Flash point data for 1,10-Phenanthroline hydrate are not available. 1,10-Phenanthroline hydrate is probably combustible.

Biochem/physiol Actions

Metalloprotease inhibitor; chelates iron, zinc and other divalent metals. Effective concentration 1-10 mM.

Purification Methods

Crystallise its picrate (m 191o) from EtOH; then the free base is liberated with aqueous alkali, dried at 78o/8mm over P2O5 and crystallised from pet ether (b 80-100o). [Cumper et al. J Chem Soc 1188 1962.] It can be purified by zone melting. It has also been crystallised from hexane, *benzene/pet ether (b 40-60o) or sodium-dried *benzene, dried and stored over H2SO4. The monohydrate is obtained by crystallisation from aqueous EtOH or ethyl acetate. It has been crystallised from H2O (300 parts) to give the monohydrate m 102-103o which sublimes at 10-3mm [Fielding & LeFevre J Chem Soc 1811 1951.] The anhydrous compound has m 118o (after drying at high vacuum at 80o) and is also obtained by recrystallisation from pet ether or *C6H6 (70 parts) and drying at 78o/8mm. [UV: Badger et al. J Chem Soc 3199 1951.] IthasapKainH2Oof 4.857 (25o) or 5.02 (20o) and 4.27 in 50% aqueous EtOH (20o). [Albert et al. J Chem Soc 2240 1948]. [Beilstein 23 H 227, 23 II 235, 23/8 V 419.]

1,10-Phenanthroline hydrate Preparation Products And Raw materials

Raw materials

Preparation Products

1 10-PHENANTHROLINE-5 6-DIONE 97 4-Vinylcyclohexene dioxide
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1,10-Phenanthroline hydrate Suppliers

Americas 1 Australia 1 Austria 1 Belgium 1 Brazil 1 Canada 2 China 400 Czech Republic 3 Europe 4 France 3 Germany 8 India 29 Japan 8 Mexico 2 Poland 1 Russia 1 South Korea 1 Switzerland 2 The Netherlands 1 Ukraine 1 United Kingdom 24 United States 71 Global 566
SHENYANG SINOCHEM BIOTECH CO.,LTD
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024-23769576 13840269002
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China
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Shenyang yimoke chemical products co. LTD
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13998106873
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297303255@qq.com
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China
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Kaiyuan city Shenxin fine chemical co., ltd.
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024-024-22595298 18698863499
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024-22595296
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China
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Shanghai Rolead Chemical Technology Co., Ltd.
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021-69992220 13701886816
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021-69992237
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roleadchem@163.com
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China
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Chongqing Yuzhiquan Biological Technology Co., Ltd.
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18306022109
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QQ:2966918840
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Shenyang Shengyuan chemical industry co., ltd
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Hunan Yongqi Chemical Co., LTD
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0731-85561035 13319583233
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yongqi@yongqichem.com
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Hu' nan Yunbang Pharmaceutical Co., Ltd.
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0731-85561037 15386497078
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yunbang@yunbangapi.com
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China
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J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
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86-10-82849933
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jkinfo@jkchemical.com
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Meryer (Shanghai) Chemical Technology Co., Ltd.
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021-61259108 18621169109
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86-21-61259102
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market03@meryer.com
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China
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View Lastest Price from 1,10-Phenanthroline hydrate manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
O-Phenanthroline Monohydrate 5144-89-8
Price
US $180.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-23
Hebei Weibang Biotechnology Co., Ltd
Product
1,10-Phenanthroline hydrate 5144-89-8
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-11-04
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
1,10-Phenanthroline hydrate 5144-89-8
Price
US $999.00-666.00/ton
Min. Order
1ton
Purity
99%
Supply Ability
5000
Release date
2024-08-20

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