trace amine receptor 1 Property

Boiling point:

330.9±25.0 °C(Predicted)

Density 

1.13±0.1 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

Soluble in DMSO

form 

Solid

pka

8.58±0.70(Predicted)

color 

White to off-white

optical activity

[α]/D 14 to 19°, c =1 in methanol

biological source

rabbit

Safety

Hazard Codes 

Xn

Risk Statements 

22

Hazard and Precautionary Statements (GHS)

trace amine receptor 1 Chemical Properties,Usage,Production

Uses

RO 5256390 is a trace amine-associated receptor 1(TAAR1) agonist which may be used as treatment of cocaine addiction.

Biological Activity

RO5256390 is an agonist of Trace amine-associated receptor 1 (TAAR1), a GPCR primarily found in the brain, expressed in areas where the major monoamine amine transmitters (DA and NE) are also present. RO5256390 is a selective TAAR1 agonist shown to be a negative regulator of dopamine transmission. It has antipsychotic activity in models of schizophrenia, reduces cocaineμs reinforcng effects, and blocks binge-eating disorder.