N,N'-Dicyclohexyl-4-morpholinecarboxamidine

Product Name: N,N'-Dicyclohexyl-4-morpholinecarboxamidine
CAS No.: 4975-73-9
Chemical Name: N,N'-Dicyclohexyl-4-morpholinecarboxamidine
Synonyms: u18177;N,N′-Dicyclohexyl-4-;Cefalexin Impurity 27;LABOTEST-BB LT00159596;4-(N,NDICYCLOHEXYLAMIDINO)MORPHOLINE;Dicyclohexyl-4-morpholinecarboxamidine;n,n’-dicyclohexyl-1-morpholinoformamidine;n,n’-dicyclohexyl-1-morpholino-formamidin;N,N'-Dicyclohexylmorpholine-4-carboxamidine;4-Morpholino-N,N'-dicyclohexylcarboxamidine
CBNumber: CB8294034
Molecular Formula: C17H31N3O
Formula Weight: 293.45
MOL File: 4975-73-9.mol

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N,N'-Dicyclohexyl-4-morpholinecarboxamidine Property

Melting point:: 105-107 °C(lit.)
Boiling point:: 423.2±55.0 °C(Predicted)
Density: 1.18±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: soluble in Methanol
form: powder to crystal
pka: 11.85±0.20(Predicted)
color: White to Almost white
InChI: 1S/C17H31N3O/c1-3-7-15(8-4-1)18-17(20-11-13-21-14-12-20)19-16-9-5-2-6-10-16/h15-16H,1-14H2,(H,18,19)
InChIKey: OZNYZQOTXQSUJM-UHFFFAOYSA-N
SMILES: C1CCC(CC1)N\C(=N\C2CCCCC2)N3CCOCC3
CAS DataBase Reference: 4975-73-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-24/25
WGK Germany: 3
RTECS: LQ4566500
HazardClass: IRRITANT
HS Code: 29349990
Storage Class: 11 - Combustible Solids
Hazard Classifications: Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 163201
Product name: N,N′-Dicyclohexyl-4-morpholinecarboxamidine
Purity: 98%
Packaging: 25g
Price: $69
Updated: 2025/07/31

TCI Chemical

Product number: D3792
Product name: N,N'-Dicyclohexyl-4-morpholinecarboxamidine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $34
Updated: 2025/07/31

TCI Chemical

Product number: D3792
Product name: N,N'-Dicyclohexyl-4-morpholinecarboxamidine
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $96
Updated: 2025/07/31

TRC

Product number: D439368
Product name: N,N''-Dicyclohexyl-4-morpholinecarboxamidine
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: D439368
Product name: N,N''-Dicyclohexyl-4-morpholinecarboxamidine
Packaging: 1g
Price: $75
Updated: 2021/12/16

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N,N'-Dicyclohexyl-4-morpholinecarboxamidine Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

N,N′-Dicyclohexyl-4-morpholinecarboxamidine was used as reagent in the synthesis of alkoxyalkyl analogs of nucleotide phosphonates, cidofovir and cyclic cidofovir.

Application

N,N'-Dicyclohexyl-4-morpholinecarboxamidine is a strong base; it is used as a catalyst for phosphorylation reactions in nucleoside chemistry.

Preparation

N,N'-Dicyclohexyl-4-morpholinecarboxamidine is easily prepared by refluxing morpholine and 1,3-Dicyclohexylcarbodiimide.

General Description

N,N′-Dicyclohexyl-4-morpholinecarboxamidine is kidney-selective ATP-sensitive potassium blocker. It is an an orally effective nonkaliuretic diuretic in rats.

Synthesis

110-91-8

538-75-0

4975-73-9

GENERAL PROCEDURE: Morpholine (0.0128 g, 0.0075 mmol), N,N'-dicyclohexylcarbodiimide (0.189 g, 1.5 mmol), and aniline (0.140 g, 1.5 mmol) were added to a dry 10 mL Schlenk tube under argon protection. The reaction mixture was stirred at 25°C for 30 min. After completion of the reaction, the mixture was extracted with ether and a clarified solution was obtained by filtration. The solvent was evaporated under reduced pressure and the residue was recrystallized by ether to afford the white solid product N,N'-dicyclohexyl-4-morpholinecarboxamidine in >99% yield.

References

[1] Journal of Organic Chemistry, 2008, vol. 73, # 22, p. 8966 - 8972
[2] Tetrahedron, 2011, vol. 67, # 45, p. 8790 - 8799
[3] Tetrahedron, 2012, vol. 68, # 29, p. 5730 - 5737
[4] Tetrahedron Letters, 2012, vol. 53, # 38, p. 5156 - 5158
[5] Journal of Organometallic Chemistry, 2014, vol. 769, p. 112 - 118

N,N'-Dicyclohexyl-4-morpholinecarboxamidine Preparation Products And Raw materials

Raw materials

Preparation Products

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N,N'-Dicyclohexyl-4-morpholinecarboxamidine Suppliers

Americas 1 China 144 Europe 1 Germany 3 India 2 Japan 2 Switzerland 1 United Kingdom 3 United States 18 Global 175

J & K SCIENTIFIC LTD.

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View Lastest Price from N,N'-Dicyclohexyl-4-morpholinecarboxamidine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: N,N'-Dicyclohexyl-4-morpholine-carboxamidine 4975-73-9
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 3500kg/month
Release date: 2021-09-14

Shaanxi Dideu Medichem Co. Ltd

Product: LABOTEST-BB LT00159596 4975-73-9
Price: US $1.00-100.00/KG
Min. Order: 1KG
Purity: 95%
Supply Ability: 300KG
Release date: 2024-08-16

Zhuozhou Wenxi import and Export Co., Ltd

Product: N,N"-Dicyclohexyl-4-morpholinecarboxamidine 4975-73-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

4975-73-9, N,N'-Dicyclohexyl-4-morpholinecarboxamidine Related Search:

Moroxydine hydrochloride N,N'-DICYCLOHEXYLUREA Moroxydine Dimethomorph Dicyclohexylcarbodiimide PNU 37883 hydrochloride 4-MORPHOLINECARBOXAMIDINE URIDINE 5'-MONOPHOSPHOMORPHOLIDATE 4-MORPHOLINE-N,N'-DICYCLOHEXYLCARBOXAMIDINE SALT ADENOSINE 5'-MONOPHOSPHO-MORPHOLIDATE 4-MORPHOLINE-N,N'-DICYCLOHEXYLCARBOXAMIDINE SALT GUANOSINE 5'-MONOPHOSPHOMORPHOLIDATE 4-MORPHOLINE-N,N'-DICYCLOHEXYLCARBOXAMIDINE SALT N,N'-Dicyclohexyl-4-morpholinecarboxamidine

n,n’-dicyclohexyl-1-morpholino-formamidin

n,n’-dicyclohexyl-1-morpholinoformamidine

u18177

N,N'-Dicyclohexylmorpholine-4-carboxamidine

LABOTEST-BB LT00159596

4-(N,NDICYCLOHEXYLAMIDINO)MORPHOLINE

N,N'-dicyclohexyl-4-morpholinecarboximidamide

4-Morpholino-N,N'-dicyclohexylcarboxamidine

N,N'-dicyclohexylmorpholine-4-carboximidamide

N,N′-Dicyclohexyl-4-

N,N'-DicyclohexylMorpholine-4-carboxaMidine, 98+%

N,N'-Dicyclohexyl-4-morpholinecarboxamidine 98%

4-Morpholinecarboximidamide, N,N'-dicyclohexyl-

4-Morpholinecarboximidamide, N,N'-dicyclohexyl- (9CI)

Dicyclohexyl-4-morpholinecarboxamidine

Formamidine, N,N'-dicyclohexyl-1-morpholino-

Morpholine-4-methanamine, N-cyclohexyl-.alpha.-(cyclohexylimino)-

N,N'-Dicyclohexyl-4-morpholinecarboxamidine&gt

4-(N,N'-Dicyclohexylcarbamimidoyl)morpholine

N,N'-Dicyclohexyl-4-morpholinecarboxamidine

Cefalexin Impurity 27

<i>N,N′</i>-Dicyclohexyl-4-morpholinecarboxamidine

N,N'-Dicyclohexyl-4-morpholinecarboxamidine

4975-73-9

C17H31N3O

Morpholines

Heterocyclic Building Blocks

Building Blocks

Biochemistry

Nucleosides, Nucleotides & Related Reagents

Phosphorylating and Phosphorothioating Agents

Protecting Agents, Phosphorylating Agents & Condensing Agents

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Morpholines