2-Chloropropionitrile Property

Melting point:

54-55 °C

Boiling point:

120-122 °C (lit.)

Density 

1.012 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.413(lit.)

Flash point:

92 °F

storage temp. 

Sealed in dry,Room Temperature

InChI

InChI=1S/C3H4ClN/c1-3(4)2-5/h3H,1H3

InChIKey

JNAYPRPPXRWGQO-UHFFFAOYSA-N

SMILES

C(#N)C(Cl)C

NIST Chemistry Reference

CH3CHClCN(1617-17-0)

Safety

Hazard Codes 

T

Risk Statements 

10-23/24/25-36/37/38

Safety Statements 

16-26-27-36/37/39-45

RIDADR 

UN 3275 6.1/PG 2

WGK Germany 

3

HazardClass 

3.2

PackingGroup 

III

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H226Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

2-Chloropropionitrile Chemical Properties,Usage,Production

Description

2-Chloropropionitrile (2-CPN) is a colorless flammable liquid with a characteristic acrid odor.

Uses

Major uses of this chemical are in pharmaceutics and polymer synthesis.

Uses

2-Chloropropionitrile was used as initiator during the single-pot atom-transfer radical polymerization under microwave irradiation for the synthesis of polyacrylonitrile. It was used in the synthesis of:

• nitrile functionalized methimazole-based ionic liquids
• (+)- and (-)-anatoxin

Environmental Fate

Most of the toxicity of propionitrile results from release of cyanide. Cause of death is due to lack of oxygen to the body’s cells, especially to the brain and heart cells.

Acquired resistance

According to Henry’s law constant of 1.43×10^-5 atmm3 mol^-1, vapor pressure of 2.770mmHg and water solubility of 45 g ml^-1 at 25°C are expected to indicate that volatilization from moist soil and water surfaces is expected to be an important fate process and also it can be volatilized from dry soil surfaces and exist as a vapor in the atmosphere.
When heated to decomposition, it emits very toxic fumes of chlorine-containing compounds: nitrogen oxides, hydrogen cyanide, and hydrogen chloride.