ChemicalBook > CAS DataBase List > 6-AMINO-1H-INDAZOLE-7-CARBOXYLIC ACID

6-AMINO-1H-INDAZOLE-7-CARBOXYLIC ACID

Product Name
6-AMINO-1H-INDAZOLE-7-CARBOXYLIC ACID
CAS No.
73907-95-6
Chemical Name
6-AMINO-1H-INDAZOLE-7-CARBOXYLIC ACID
Synonyms
TIMTEC-BB SBB002550;7-Carboxy-1H-indazole-6-amine;6-Amino-7-carboxy-1H-indazole;6-AMINO-1H-INDAZOLE-7-CARBOXYLIC ACID;1H-Indazole-7-carboxylic acid, 6-aMino-
CBNumber
CB8296412
Molecular Formula
C8H7N3O2
Formula Weight
177.16
MOL File
Mol file
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6-AMINO-1H-INDAZOLE-7-CARBOXYLIC ACID Property

Melting point:
177 °C (decomp)
Boiling point:
501.6±35.0 °C(Predicted)
Density 
1.611
storage temp. 
Sealed in dry,Room Temperature
form 
Solid
pka
16.17±0.40(Predicted)
Appearance
Yellow to brown Solid
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
22
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
A637108
Product name
6-Amino-1H-indazole-7-carboxylicacid
Packaging
500mg
Price
$265
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA143601
Product name
6-Amino-1H-indazole-7-carboxylic acid
Packaging
100mg
Price
$61
Updated
2021/12/16
SynQuest Laboratories
Product number
4H57-1-Y2
Product name
6-Amino-1H-indazole-7-carboxylic acid
Packaging
100mg
Price
$77
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA143601
Product name
6-Amino-1H-indazole-7-carboxylic acid
Packaging
250mg
Price
$120
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA143601
Product name
6-Amino-1H-indazole-7-carboxylic acid
Packaging
500mg
Price
$210
Updated
2021/12/16
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6-AMINO-1H-INDAZOLE-7-CARBOXYLIC ACID Chemical Properties,Usage,Production

Synthesis

73907-94-5

73907-95-6

Pyrrolo[2,3-g]indazole-7,8(1H,6H)-dione (Formula 7, the product of Example II, 9.4 g, 50 mmol) was used as a raw material, which was dissolved in 10% aqueous sodium hydroxide solution (100 mL). Subsequently, 10% aqueous hydrogen peroxide solution (17 mL, 50 mmol) was slowly added at 100 °C. The reaction mixture was kept at 100°C for 10 minutes until the release of carbon dioxide gas stopped. Next, the pH of the reaction solution was adjusted with concentrated hydrochloric acid to 4.0-5.5. The resulting 6-amino-1H-indazole-7-carboxylic acid (formula 8) was collected by filtration and washed with cold water, and finally dried under vacuum in the presence of CaCl2 to give 7.71 g of the product in brown powder form in 87% yield with a melting point of 205 °C (decomposition started at 177 °C). The infrared spectrum (KBr) of the product showed characteristic absorption peaks: 1580, 1630, 1660 cm-1 (corresponding to aromatic ring and carbonyl carboxylic acid, respectively). The NMR hydrogen spectrum (100 MHz, DMSO-d6) data were as follows: δ 6.70 (d, 1H, J=9Hz, H-4), ca. 6.80-9.00 (D2O-exchangeable broad peak, 2H, NH2), 7.66 (d, 1H, J=9Hz, H-5), and 7.93 (s, 1H, H-3). The mass spectrum (70 eV) showed molecular ion peaks m/e 177 (100%, M+) and m/e 159 (86%, M+-H2O). Samples recrystallized from methanol failed to yield satisfactory data by elemental analysis.

References

[1] Tetrahedron Letters, 1980, vol. 21, # 32, p. 3029 - 3032
[2] Journal of Organic Chemistry, 1980, vol. 45, # 15, p. 3072 - 3077
[3] Heterocycles, 1981, vol. 15, # 2, p. 1053 - 1059
[4] Patent: US4223143, 1980, A
[5] Patent: WO2007/93402, 2007, A1. Location in patent: Page/Page column 42

6-AMINO-1H-INDAZOLE-7-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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6-AMINO-1H-INDAZOLE-7-CARBOXYLIC ACID Suppliers

China 60 Finland 1 France 2 India 1 Russia 1 United Kingdom 2 United States 13 Global 80
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View Lastest Price from 6-AMINO-1H-INDAZOLE-7-CARBOXYLIC ACID manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
6-AMINO-1H-INDAZOLE-7-CARBOXYLIC ACID 73907-95-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-18
Career Henan Chemical Co
Product
6-AMINO-1H-INDAZOLE-7-CARBOXYLIC ACID 73907-95-6
Price
US $1.00/KG
Min. Order
1KG
Purity
99%Min
Supply Ability
10 tons
Release date
2019-09-10

73907-95-6, 6-AMINO-1H-INDAZOLE-7-CARBOXYLIC ACIDRelated Search:

6-AMINO-4-CHLORO-1H-INDAZOLE 6-AMINO-4-INDAZOLECARBOXYLIC ACID METHYL ESTER 1-(Tetrahydro-pyran-2-yl)-1H-indazol-6-ylamine 6-AMINO-5-METHYLNICOTINONITRILE 1H-indazole-7-carboxylic acid

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  • 1H-Indazole-7-carboxylic acid, 6-aMino-
  • TIMTEC-BB SBB002550
  • 73907-95-6
  • 73907956
  • Indazoles