ChemicalBook > CAS DataBase List > 16-Bromohexadecanoic acid

16-Bromohexadecanoic acid

Product Name
16-Bromohexadecanoic acid
CAS No.
2536-35-8
Chemical Name
16-Bromohexadecanoic acid
Synonyms
16-Bromopalmitic acid;16-Brom-hexadecaneSre;6-Bromohexadecanoic acid;16-Brom-hexadecanoicacid;16-BROMOHEXADECANOIC ACID;Hexadecanoic acid, 16-bromo-;16-Bromohexadecanoic acid 95%;16-BROMOHEXADECANOIC ACID, 99+%;16-BROMO-HEXADECANECARBOXYLIC ACID;16-Bromohexadecanoic acid (work in progress)
CBNumber
CB8301444
Molecular Formula
C16H31BrO2
Formula Weight
335.32
MOL File
2536-35-8.mol
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16-Bromohexadecanoic acid Property

Melting point:
68-71 °C (lit.) 70-73 °C (lit.)
Boiling point:
214-217 °C/1 mmHg (lit.)
Density 
1.116±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
form 
solid
pka
4.78±0.10(Predicted)
color 
White
InChI
InChI=1S/C16H31BrO2/c17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16(18)19/h1-15H2,(H,18,19)
InChIKey
PFNCOYVEMJYEED-UHFFFAOYSA-N
SMILES
C(O)(=O)CCCCCCCCCCCCCCCBr
CAS DataBase Reference
2536-35-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
38
Safety Statements 
37
WGK Germany 
3
Hazard Note 
Irritant
HS Code 
2915907098
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
568708
Product name
16-Bromohexadecanoic acid
Purity
≥99%
Packaging
5g
Price
$363.3
Updated
2025/07/31
TRC
Product number
B687953
Product name
16-Bromohexadecanoic acid
Packaging
50mg
Price
$45
Updated
2021/12/16
TRC
Product number
B687953
Product name
16-Bromohexadecanoic acid
Packaging
100mg
Price
$60
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB153858
Product name
16-Bromohexadecanoic acid
Packaging
500mg
Price
$70
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB153858
Product name
16-Bromohexadecanoic acid
Packaging
1g
Price
$118
Updated
2021/12/16
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16-Bromohexadecanoic acid Chemical Properties,Usage,Production

Uses

16-Bromohexadecanoic acid can be used:

  • As a starting material in the synthesis of ceramides with ultralong chains.
  • In the synthesis of 6-(nitrooxy)hexadecanoic acid intermediate, which on reacting with (L)-carnitine ethyl ester iodide gave carnitine nitro-derivatives.

Synthesis

506-13-8

2536-35-8

Synthesis of 16-bromohexadecanoic acid 2: To a 2 L three-necked round-bottomed flask equipped with a mechanical stirrer, a reflux condenser tube, and a nitrogen introduction tube was added 177 g (0.63 mol) of 16-hydroxyhexadecanoic acid 1. Subsequently, 1000 mL (5 mol) of 30% hydrogen bromide in acetic acid solution and 310 mL of concentrated sulfuric acid were added. The system was connected to sequential trapping devices, sequentially a sodium hydroxide particle trap, a 25% aqueous sodium hydroxide solution trap and a saturated sodium carbonate solution trap. The reaction mixture was stirred overnight at room temperature and subsequently heated to reflux for 6 hours. Upon completion of the reaction, the mixture was cooled and poured into ice water and the precipitated solid was vacuum filtered. After high vacuum drying, 196 g of 16-bromohexadecanoic acid 2 was obtained Yield: 88%; Purity: >95%; Melting point: 67-69 °C; DSC: 69.0 °C (sharp); IR (paraffin paste): 1700 cm?1 (strong), 650 cm?1 (strong); 1H NMR (200 MHz, CD2Cl2): δ 3.4 (t, J = 8 Hz, 2H), 2.3 (t, J = 8 Hz, 2H), 1.8 (m, 2H), 1.6 (m, 2H), 1.2 (br.s, 22H).

References

[1] Tetrahedron Letters, 1999, vol. 40, # 10, p. 2011 - 2014
[2] Tetrahedron, 2000, vol. 56, # 51, p. 9975 - 9984
[3] Patent: US5502226, 1996, A
[4] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993, # 10, p. 1183 - 1190
[5] Helvetica Chimica Acta, 1929, vol. 12, p. 478

16-Bromohexadecanoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 16-Bromohexadecanoic acid manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
16-Bromohexadecanoic acid 2536-35-8
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-05-20
PNP Biotech Co. Ltd
Product
16-Bromohexadecanoic acid 2536-35-8
Price
US $0.00/KG
Min. Order
25KG
Purity
95%
Supply Ability
Inquiry
Release date
2022-09-28
Zhuozhou Wenxi import and Export Co., Ltd
Product
16-Bromohexadecanoic acid 2536-35-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27

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