(R)-1-(3-Bromophenyl)ethylamine

(R)-1-(3-Bromophenyl)ethylamine Property

Boiling point:

96°C/4mm

Density 

1.33

Flash point:

96°C/4mm

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

8.73±0.10(Predicted)

Appearance

Colorless to light yellow Liquid

optical activity

Consistent with structure

Sensitive 

Air Sensitive

Safety

Hazard Codes 

C,N

Risk Statements 

34-51/53-43-22

Safety Statements 

26-36/37/39-61-45

RIDADR 

2735

HazardClass 

8

PackingGroup 

III

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

H317May cause an allergic skin reaction

H318Causes serious eye damage

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

(R)-1-(3-Bromophenyl)ethylamine Chemical Properties,Usage,Production

Synthesis

The general procedure for the synthesis of (R)-1-(3-bromophenyl)ethylamine from 1-(3-bromophenyl)ethanone oxime is as follows: 1 equiv. of N-[1-(3-bromophenyl)ethylidene]hydroxylamine, 5 mol% of RuCl(Cymene)(S-tol-Binap)Cl catalyst, 5 equiv. of additives, and 70 vol. of methanol (relative to the amount of the oxime) are added to a glass vial. The glass vials were placed in a parallel autoclave, which was pressurized to 30 bar with hydrogen, then heated to 90 °C and kept for 24 hours. After completion of the reaction, the system was cooled to 20 °C. The reaction mixture was diluted with isopropyl alcohol. The reaction mixture was diluted with isopropanol and analyzed by chiral HPLC.

References

[1] Patent: WO2015/178847, 2015, A1. Location in patent: Page/Page column 7-8