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ceralifimod

Product Name
ceralifimod
CAS No.
891859-12-4
Chemical Name
ceralifimod
Synonyms
ONO-4641;ceralifimod;Ceralifimod (ONO-4641);Ceralifimod (Synonyms: ONO-4641);3-Azetidinecarboxylic acid, 1-[[3,4-dihydro-6-[(2-methoxy-4-propylphenyl)methoxy]-1-methyl-2-naphthalenyl]methyl]-
CBNumber
CB83032842
Molecular Formula
C27H33NO4
Formula Weight
435.56
MOL File
891859-12-4.mol
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ceralifimod Property

Boiling point:
595.9±50.0 °C(Predicted)
Density 
1.172±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:5.0(Max Conc. mg/mL);11.48(Max Conc. mM)
form 
A crystalline solid
pka
2.71±0.20(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
24159
Product name
Ceralifimod
Purity
≥95%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
24159
Product name
Ceralifimod
Purity
≥95%
Packaging
5mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
24159
Product name
Ceralifimod
Purity
≥95%
Packaging
10mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
24159
Product name
Ceralifimod
Purity
≥95%
Packaging
25mg
Price
$305
Updated
2024/03/01
Tocris
Product number
6690
Product name
Ceralifimod
Purity
≥95%(HPLC)
Packaging
10
Price
$123
Updated
2021/12/16
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ceralifimod Chemical Properties,Usage,Production

Description

Ceralifimod is an agonist of the sphingosine-1-phosphate (S1P) receptors S1P1 and S1P5 (Kis = 0.626 and 0.574 nM, respectively). It is selective for S1P1 and S1P5 over S1P2-4 (Kis = >5,450, >5,630, and 28.8 nM, respectively). Ceralifimod induces calcium influx in CHO-K1 cells overexpressing S1P1 (EC50 = 1 nM) and cAMP accumulation in CHO-K1 cells overexpressing S1P1 or S1P5 (EC50s = 0.027 and 0.33 nM, respectively). In vivo, ceralifimod (0.03 and 0.1 mg/kg) reduces paw edema in a rat model of collagen induced arthritis (CIA). It also delays disease onset and inhibits lymphocyte infiltration of the spinal cord in a rat model of experimental autoimmune encephalomyelitis (EAE) and prevents disease relapse in a non-obese diabetic mouse model of relapsing-remitting EAE.

storage

Store at -20°C

ceralifimod Preparation Products And Raw materials

Raw materials

Preparation Products

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ceralifimod Suppliers

China 26 United States 5 Global 31
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3423
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131981
Advantage
58
Jinan Yaoyan Pharmaceutical Co., Ltd.
Tel
Fax
-
Email
jnyaoyan@163.com
Country
China
ProdList
3069
Advantage
58
Shanghai Medicil Biomedical Co., Ltd.
Tel
021-50822001
Email
marketing@medicilon.com.cn
Country
China
ProdList
1152
Advantage
58
Hangzhou Synstar pharmaceutical Technology CO.,Ltd
Tel
0571-85361029
Fax
0571-85361029
Email
synstar518@163.com
Country
China
ProdList
1991
Advantage
58
Taizhou Crene Biotechnology Co. Ltd.
Tel
0576-88813233 13396860566
Email
sales@pharm-intermediates.com
Country
China
ProdList
2013
Advantage
58
Nanjing Meihao Pharmaceutical Technology Co., Ltd.
Tel
meitaochem@126.com
Email
meitaochem@126.com
Country
China
ProdList
19105
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
19892
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6393
Advantage
58
Beijing xinyanhui pharmaceutical research and development co., LTD
Tel
13969155946
Email
1461866103@qq.com
Country
China
ProdList
16111
Advantage
58

891859-12-4, ceralifimodRelated Search:


  • Ceralifimod (Synonyms: ONO-4641)
  • ceralifimod
  • ONO-4641
  • 3-Azetidinecarboxylic acid, 1-[[3,4-dihydro-6-[(2-methoxy-4-propylphenyl)methoxy]-1-methyl-2-naphthalenyl]methyl]-
  • Ceralifimod (ONO-4641)
  • 891859-12-4