ceralifimod
- Product Name
- ceralifimod
- CAS No.
- 891859-12-4
- Chemical Name
- ceralifimod
- Synonyms
- ONO-4641;ceralifimod;Ceralifimod (ONO-4641);Ceralifimod (Synonyms: ONO-4641);3-Azetidinecarboxylic acid, 1-[[3,4-dihydro-6-[(2-methoxy-4-propylphenyl)methoxy]-1-methyl-2-naphthalenyl]methyl]-
- CBNumber
- CB83032842
- Molecular Formula
- C27H33NO4
- Formula Weight
- 435.56
- MOL File
- 891859-12-4.mol
ceralifimod Property
- Boiling point:
- 595.9±50.0 °C(Predicted)
- Density
- 1.172±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:5.0(Max Conc. mg/mL);11.48(Max Conc. mM)
- form
- A crystalline solid
- pka
- 2.71±0.20(Predicted)
N-Bromosuccinimide Price
- Product number
- 24159
- Product name
- Ceralifimod
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 24159
- Product name
- Ceralifimod
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $93
- Updated
- 2024/03/01
- Product number
- 24159
- Product name
- Ceralifimod
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $139
- Updated
- 2024/03/01
- Product number
- 24159
- Product name
- Ceralifimod
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $305
- Updated
- 2024/03/01
- Product number
- 6690
- Product name
- Ceralifimod
- Purity
- ≥95%(HPLC)
- Packaging
- 10
- Price
- $123
- Updated
- 2021/12/16
ceralifimod Chemical Properties,Usage,Production
Description
Ceralifimod is an agonist of the sphingosine-1-phosphate (S1P) receptors S1P1 and S1P5 (Kis = 0.626 and 0.574 nM, respectively). It is selective for S1P1 and S1P5 over S1P2-4 (Kis = >5,450, >5,630, and 28.8 nM, respectively). Ceralifimod induces calcium influx in CHO-K1 cells overexpressing S1P1 (EC50 = 1 nM) and cAMP accumulation in CHO-K1 cells overexpressing S1P1 or S1P5 (EC50s = 0.027 and 0.33 nM, respectively). In vivo, ceralifimod (0.03 and 0.1 mg/kg) reduces paw edema in a rat model of collagen induced arthritis (CIA). It also delays disease onset and inhibits lymphocyte infiltration of the spinal cord in a rat model of experimental autoimmune encephalomyelitis (EAE) and prevents disease relapse in a non-obese diabetic mouse model of relapsing-remitting EAE.
storage
Store at -20°C
ceralifimod Preparation Products And Raw materials
Raw materials
Preparation Products
ceralifimod Suppliers
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
- Country
- United States
- ProdList
- 19892
- Advantage
- 58
- Tel
- +1-708-310-1919 +1-13798911105
- Fax
- 708-557-7486
- sales@invivochem.cn
- Country
- United States
- ProdList
- 6393
- Advantage
- 58
- Tel
- +1-+1(833)-552-7181
- sales@aladdinsci.com
- Country
- United States
- ProdList
- 52927
- Advantage
- 58