Mirin
- Product Name
- Mirin
- CAS No.
- 1198097-97-0
- Chemical Name
- Mirin
- Synonyms
- CS-2593;(Z)-Mirin;(Z)-Mirin, 10 mM in DMSO;(Z)-Mirin,Inhibitor,(Z)Mirin,(Z) Mirin,inhibit;(Z)-2-Amino-5-(4-hydroxybenzylidene)thiazol-4(5H)-one;(5Z)-2-Amino-5-[(4-hydroxyphenyl)methylene]-4(5H)-thiazolone;4(5H)-Thiazolone, 2-amino-5-[(4-hydroxyphenyl)methylene]-, (5Z)-;(5Z) -2-amino-5- [(4-hydroxyphenyl) methylene] -4 (5H) - thiazolidone
- CBNumber
- CB83037397
- Molecular Formula
- C10H8N2O2S
- Formula Weight
- 220.25
- MOL File
- 1198097-97-0.mol
Mirin Property
- Boiling point:
- 441.6±55.0 °C(Predicted)
- Density
- 1.49±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- insoluble in EtOH; insoluble in H2O; ≥9.3 mg/mL in DMSO
- form
- solid
- pka
- 8.70±0.30(Predicted)
- color
- Light yellow to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- M3303
- Product name
- Mirin
- Packaging
- 25MG
- Price
- $115
- Updated
- 2025/07/31
- Product number
- M3303
- Product name
- Mirin
- Packaging
- 100MG
- Price
- $288
- Updated
- 2025/07/31
- Product number
- M364938
- Product name
- Mirin
- Packaging
- 50mg
- Price
- $225
- Updated
- 2021/12/16
- Product number
- B5389
- Product name
- Mirin
- Packaging
- 50mg
- Price
- $228
- Updated
- 2021/12/16
- Product number
- INB0004757
- Product name
- 2-AMINO-5-[(4-HYDROXYPHENYL)METHYLENE]-, (5Z)-4(5H)-THIAZOLONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.78
- Updated
- 2021/12/16
Mirin Chemical Properties,Usage,Production
Uses
Mirin is an MRN-ATM pathway inhibitor blocking 3’ and 5’ exonuclease activity associated with Mre11, inducing G2 cell cycle arrest.
Biological Activity
mirin is a potent mrn complex inhibitor. mirin inhibits mre11-associated exonuclease activity, rather than alters dna-binding or mrn complex formation. moreover, mirin prevents mrn-dependent activation of atm in response to dna double-strand breaks, with an ic50 value of 12 μm. the mrn complex acts as a dna damage sensor, responsible for maintaining genome stability during dna replication, promoting homology-dependent dna repair and activating atm. the mrn-atm pathway plays an essential role in sensing and signaling from dna double-strand breaks.1. dupré a, boyer-chatenet l, sattler rm, et al. a forward chemical genetic screen reveals an inhibitor of the mre11-rad50-nbs1 complex. nature chemical biology, 2008, 4(2): 119-125.
Synthesis
123-08-0
556-90-1
1198097-97-0
GENERAL METHODS: (Z)-2-Amino-5-(4-hydroxybenzylidene)thiazol-4(5H)-one was synthesized from p-hydroxybenzaldehyde and pseudothioglycolide. The procedure was as follows: a mixture of p-hydroxybenzaldehyde (300 mg), pseudothioglycolide (1.1 eq.) and sodium acetate (3.0 eq.) was heated and refluxed for 3 to 7 hours under acetic acid (4 mL/1 g sodium acetate) as a solvent. Upon completion of the reaction, the reaction mixture was cooled and water was added to precipitate the product. The precipitate was collected by filtration and washed with water, dichloromethane and/or ethyl acetate depending on the physical properties of the starting material to finalize the target product. The product was an orange solid with a reaction time of 3 hours, a yield of 61.8% and a melting point of over 300 °C. The structure of the product was determined by 1H NMR (500 MHz, DMSO-d6) δ 10.10 (s, 1H), 9.29 (brs, 1H), 9.04 (s, 1H), 7.49 (s, 1H), 7.40 (d, 2H, J = 9.0 Hz), 6.88 (d, 2H, J = 8.5Hz); 13C NMR (100 MHz, DMSO-d6) δ 181.4, 176.1, 159.6, 132.1, 130.2, 126.0, 125.5, 116.8; and mass spectrometry (ESI) m/z 219 ([M-H]-) were confirmed.
storage
Store at +4°C
References
[1] Journal of Medicinal Chemistry, 2010, vol. 53, # 1, p. 273 - 281
[2] Patent: US2014/23603, 2014, A1. Location in patent: Paragraph 0268; 0271
[3] Patent: KR101677122, 2016, B1. Location in patent: Paragraph 0411-0412; 0417
[4] Bioscience, Biotechnology and Biochemistry, 2018, vol. 82, # 5, p. 759 - 767
[5] Synthetic Communications, 2013, vol. 43, # 7, p. 961 - 978
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View Lastest Price from Mirin manufacturers
- Product
- Mirin 1198097-97-0
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2000ton
- Release date
- 2023-08-29
- Product
- (5Z)-2-Amino-5-[(4-hydroxyphenyl)methylene]-4(5H)-thiazolone 1198097-97-0
- Price
- US $1.00/ASSAYS
- Min. Order
- 1ASSAYS
- Purity
- 95%~99%
- Supply Ability
- per week:100kg
- Release date
- 2019-09-05