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RPT-835(alofanib)

Product Name
RPT-835(alofanib)
CAS No.
1612888-66-0
Chemical Name
RPT-835(alofanib)
Synonyms
RPT835;CS-2880;Alofanib;ES 000835;RPT-835; RPT 835;Alofanib (RPT835);RPT-835(alofanib);Alofanib, 10 mM in DMSO;RPT-835;RPT835;RPT 835;ES 000835;3-[[4-methyl-2-nitro-5-(3-pyridyl)phenyl]sulfamoyl]benzoic acid
CBNumber
CB83043327
Molecular Formula
C19H15N3O6S
Formula Weight
413.4
MOL File
1612888-66-0.mol
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RPT-835(alofanib) Property

Boiling point:
659.6±65.0 °C(Predicted)
Density 
1.488±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:47.7(Max Conc. mg/mL);115.38(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:6):0.14(Max Conc. mg/mL);0.34(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);72.57(Max Conc. mM)
form 
A crystalline solid
pka
3.59±0.10(Predicted)
color 
Light yellow to yellow
InChI
InChI=1S/C19H15N3O6S/c1-12-8-18(22(25)26)17(10-16(12)14-5-3-7-20-11-14)21-29(27,28)15-6-2-4-13(9-15)19(23)24/h2-11,21H,1H3,(H,23,24)
InChIKey
QUQGQIASFYWKAB-UHFFFAOYSA-N
SMILES
C(O)(=O)C1=CC=CC(S(NC2=CC(C3=CC=CN=C3)=C(C)C=C2[N+]([O-])=O)(=O)=O)=C1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0014684
Product name
Alofanib
Purity
98.81%
Packaging
5mg
Price
$120
Updated
2021/12/16
ChemScene
Product number
CS-0014684
Product name
Alofanib
Purity
98.81%
Packaging
10mg
Price
$210
Updated
2021/12/16
ChemScene
Product number
CS-0014684
Product name
Alofanib
Purity
98.81%
Packaging
25mg
Price
$420
Updated
2021/12/16
ChemScene
Product number
CS-0014684
Product name
Alofanib
Purity
98.81%
Packaging
50mg
Price
$720
Updated
2021/12/16
Biorbyt Ltd
Product number
orb573162
Product name
Alofanib
Purity
>98%
Packaging
100mg
Price
$912.9
Updated
2021/12/16
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RPT-835(alofanib) Chemical Properties,Usage,Production

Uses

Alofanib (RPT835) is a potent and selective allosteric inhibitor of fibroblast growth factor receptor 2 (FGFR2). Anticancer and antiangiogenic activity[1][2].

in vivo

In a FGFR-driven human tumour xenograft model, oral administration of alofanib (30 mg/kg, gavage, daily, 40 days, N=10) is well tolerated and results in potent antitumour activity[1].

Treatment with alofanib (10 mg/kg/d, 0, 3 and 6 d, intraperitoneally) ablates experimental FGF-induced angiogenesis in vivo[1].

Animal Model:C57Bl/6 × DBA/2 F1 mice of 22–30 g[1]
Dosage:10 mg/kg/d
Administration:Intraperitoneally, 0, 3 and 6 d
Result:Alofanib inhibits angiogenesis in mouse models[1].

IC 50

FGFR2

References

[1] Tsimafeyeu I, et al. Targeting FGFR2 with alofanib (RPT835) shows potent activity in tumour models. Eur J Cancer. 2016 Jul;61:20-8. DOI:10.1016/j.ejca.2016.03.068
[2] Khochenkov DA, et al. Antiangiogenic Activity of Alofanib, an Allosteric Inhibitor of Fibroblast Growth Factor Receptor 2. Bull Exp Biol Med. 2015 Nov;160(1):84-7. DOI:10.1007/s10517-015-3104-5

RPT-835(alofanib) Preparation Products And Raw materials

Raw materials

Preparation Products

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RPT-835(alofanib) Suppliers

China 65 India 1 United States 7 Global 73
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
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58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
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58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19552
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58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
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58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
Cayman Chemical Company
Tel
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Fax
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Email
cayman@caymanchem.com
Country
United States
ProdList
6213
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81

1612888-66-0, RPT-835(alofanib)Related Search:


  • RPT835
  • RPT-835(alofanib)
  • 3-(N-(4-methyl-2-nitro-5-(pyridin-3-yl)phenyl)sulfamoyl)benzoic acid
  • Alofanib (RPT835)
  • Alofanib
  • CS-2880
  • ES 000835
  • RPT-835;RPT835;RPT 835;ES 000835
  • RPT-835; RPT 835
  • Benzoic acid, 3-[[[4-methyl-2-nitro-5-(3-pyridinyl)phenyl]amino]sulfonyl]-
  • Apoptosis,FGFR,Inhibitor,inhibit,RPT-835,RPT 835,Fibroblast growth factor receptor,Alofanib
  • 3-[N-[4-Methyl-2-nitro-5-(3-pyridyl)phenyl]sulfamoyl]benzoic Acid
  • 3-[[4-methyl-2-nitro-5-(3-pyridyl)phenyl]sulfamoyl]benzoic acid
  • Alofanib, 10 mM in DMSO
  • 1612888-66-0