2-Bromo-4-hydroxybenzoicacid
- Product Name
- 2-Bromo-4-hydroxybenzoicacid
- CAS No.
- 28547-28-6
- Chemical Name
- 2-Bromo-4-hydroxybenzoicacid
- Synonyms
- 2-Bromo-4-hydroxybenzoicacid;Benzoic acid, 2-bromo-4-hydroxy-
- CBNumber
- CB83044339
- Molecular Formula
- C7H5BrO3
- Formula Weight
- 217.02
- MOL File
- 28547-28-6.mol
2-Bromo-4-hydroxybenzoicacid Property
- Melting point:
- 151 °C
- Boiling point:
- 366.3±32.0 °C(Predicted)
- Density
- 1.861±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- form
- powder
- pka
- 3.22±0.10(Predicted)
- color
- Off-white
Safety
- HS Code
- 2918999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B852600
- Product name
- 2-Bromo-4-hydroxybenzoicacid
- Packaging
- 10mg
- Price
- $40
- Updated
- 2021/12/16
- Product number
- CS-0037965
- Product name
- 2-Bromo-4-hydroxybenzoicacid
- Purity
- 98.84%
- Packaging
- 250mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- OR400738
- Product name
- 2-Bromo-4-hydroxybenzoicacid
- Purity
- 95%
- Packaging
- 5g
- Price
- $696
- Updated
- 2021/12/16
- Product number
- 2629-9-28
- Product name
- 2-Bromo-4-hydroxybenzoic acid
- Purity
- 97%
- Packaging
- 5G
- Price
- $768
- Updated
- 2021/12/16
- Product number
- OR400738
- Product name
- 2-Bromo-4-hydroxybenzoicacid
- Purity
- 95%
- Packaging
- 250mg
- Price
- $80
- Updated
- 2021/12/16
2-Bromo-4-hydroxybenzoicacid Chemical Properties,Usage,Production
Uses
2-Bromo-4-hydroxybenzoic acid is a bromo derivative of hydroxybenzoic acid, a useful building block. 2-Bromo-4-hydroxybenzoic acid has been used in the preparation of urolithins which interfere with the CYP1B1 protein which is linked with prostate cancer.
Synthesis
22532-60-1
28547-28-6
2-Bromo-4-hydroxybenzaldehyde (1.7 g, 8.46 mmol, 1.0 equiv) was used as starting material and dissolved in 30 mL of 2 M aqueous sodium hydroxide solution. Potassium permanganate (2.7 g, 16.92 mmol, 2.0 equiv) was added in batches under ice bath cooling conditions. The reaction mixture was then slowly warmed to room temperature with continuous stirring for 2 hours. After completion of the reaction, the insoluble impurities were removed by filtration and the filtrate was washed once with dichloromethane. To the filtrate, 2 M aqueous hydrochloric acid was slowly added and the pH was adjusted to 1. The aqueous phase was extracted with ethyl acetate, the organic phases were combined and dried over anhydrous sodium sulfate. The organic phase was concentrated under reduced pressure to give the white solid product 2-bromo-4-hydroxybenzoic acid (1.6 g, 88% yield).
References
[1] Patent: CN107383024, 2017, A. Location in patent: Paragraph 0481
2-Bromo-4-hydroxybenzoicacid Preparation Products And Raw materials
Raw materials
Preparation Products
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