Lorediplon
- Product Name
- Lorediplon
- CAS No.
- 917393-39-6
- Chemical Name
- Lorediplon
- Synonyms
- Lorediplon;Thionorphine Hydrochloride;Acetamide, N-[2-fluoro-5-[3-(2-thienylcarbonyl)pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]-N-methyl-;N-[2-fluoro-5-[3-(thiophene-2-carbonyl)pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]-N-methylacetamide;GABA Receptor,γ-Aminobutyric acid Receptor,inhibit,Inhibitor,Lorediplon,Gamma-aminobutyric acid Receptor
- CBNumber
- CB83053906
- Molecular Formula
- C20H15FN4O2S
- Formula Weight
- 394.42
- MOL File
- 917393-39-6.mol
Lorediplon Property
- storage temp.
- Store at -20°C
- solubility
- DMF: 25 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 14 mg/ml
- form
- A crystalline solid
N-Bromosuccinimide Price
- Product number
- 23868
- Product name
- Lorediplon
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 23868
- Product name
- Lorediplon
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $61
- Updated
- 2024/03/01
- Product number
- 23868
- Product name
- Lorediplon
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $139
- Updated
- 2024/03/01
- Product number
- 23868
- Product name
- Lorediplon
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $243
- Updated
- 2024/03/01
- Product number
- 2092CT
- Product name
- Lorediplon
- Packaging
- 25mg
- Price
- $252
- Updated
- 2021/12/16
Lorediplon Chemical Properties,Usage,Production
Description
Lorediplon is a non-benzodiazepine belonging to pyrazolopyrimidine family isunderdevelopment for the management for insomnia. Lorediplon acts by modulationof the GABAgreceptor. Its long plasma half-life has the potential of hypnotic effect. Ithas the potential for maintenance of sleep and the sleep architecture. In the phase Ipharmacodynamic study,it showed better efficacy in quality and maintenance ofsleep as compared with zolpidem. It has been shown to be well tolerated, safe with noresidual effects as compared with other sedative-hypnotic. Currently, the drug has completed Phase ll clinical trial. Results indicated strongefficacy in sleep maintenance with an acceptable safety profile. It also seems topreserve natural sleep architecture.
Uses
Lorediplon is GABAA receptor modulator and is used in the treatment of insomnia.
Biological Activity
Lorediplon is a ligand for α1 subunit-containing GABAA receptors. In vivo, lorediplon inhibits spontaneous motor activity and increases duration of sleep in mice (ED50s = 0.13 and 1.2 mg/kg, respectively). It selectively inhibits spontaneous motor activity, which is driven by α1 subunit-containing GABAA receptors, over modification of muscular tone in mice, an α2 subunit-containing GABAA receptor-stimulated activity. Lorediplon (0.13 and 1.2 mg/kg) also decreases latency to slow wave sleep (SWS) and paradoxical sleep (PS) in mice. Formulations containing lorediplon have been used in the treatment of insomnia.
Lorediplon Preparation Products And Raw materials
Raw materials
Preparation Products
Lorediplon Suppliers
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View Lastest Price from Lorediplon manufacturers
- Product
- Lorediplon 917393-39-6
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2024-03-26
- Product
- Lorediplon 917393-39-6
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10T
- Release date
- 2024-01-25