N-AMINOPHTHALIMIDE Property

Melting point:

200-202 °C(lit.)

Boiling point:

288.82°C (rough estimate)

Density 

1.3264 (rough estimate)

refractive index 

1.5770 (estimate)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

Solubility in hot methanol almost transparent.

pka

-1.73±0.20(Predicted)

form 

powder to crystal

color 

White to Light yellow

BRN 

383756

InChI

InChI=1S/C8H6N2O2/c9-10-7(11)5-3-1-2-4-6(5)8(10)12/h1-4H,9H2

InChIKey

KSILMCDYDAKOJD-UHFFFAOYSA-N

SMILES

C1(=O)C2=C(C=CC=C2)C(=O)N1N

CAS DataBase Reference

1875-48-5(CAS DataBase Reference)

Safety

Hazard Codes 

Xn

Risk Statements 

36/37/38-42/43

Safety Statements 

22-26-36/37-45

WGK Germany 

3

F 

9

HS Code 

29251900

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

N-AMINOPHTHALIMIDE Chemical Properties,Usage,Production

Chemical Properties

white to off-white crystalline powder

Uses

It is employed in the aziridination of chiral N-enoyl sultams. It is also used in the synthesis of n-phthalimidoaziridines

Uses

N-Aminophthalimide was employed in the aziridination of chiral N-enoyl sultams. It was also used in the synthesis of n-phthalimidoaziridines.

Purification Methods

The imide has been recrystallised from 96% EtOH (solubility is ~2% at boiling temperature) to form a yellow solution. It sublimes in vacuo at ca 150o. It solidifies after melting, and remelts at 338-341o (see phthalhydrazide in “Heterocyclic Compounds, Chapter 4”). [Beilstein 22/11 V 122.]