ChemicalBook > CAS DataBase List > Cuspin-1
Cuspin-1
- Product Name
- Cuspin-1
- CAS No.
- 337932-29-3
- Chemical Name
- Cuspin-1
- Synonyms
- Cuspin-1;Cuspin 1,Cuspin1;Cuspin-1 >=98% (HPLC);(5-Bromo-3-pyridinyl)(4-methylphenyl)methanone;Methanone, (5-bromo-3-pyridinyl)(4-methylphenyl)-
- CBNumber
- CB83067543
- Molecular Formula
- C13H10BrNO
- Formula Weight
- 276.1286
- MOL File
- 337932-29-3.mol
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Cuspin-1 Property
- storage temp.
- Store at -20°C
- solubility
- DMF: 25 mg/mL; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 16 mg/mL; Ethanol: 1 mg/mL
- form
- A crystalline solid
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 18526
- Product name
- Cuspin-1
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $57
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 18526
- Product name
- Cuspin-1
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $95
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 18526
- Product name
- Cuspin-1
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $208
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 18526
- Product name
- Cuspin-1
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $384
- Updated
- 2024/03/01
TRC
- Product number
- C845005
- Product name
- Cuspin1
- Packaging
- 10mg
- Price
- $85
- Updated
- 2021/12/16
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Cuspin-1 Chemical Properties,Usage,Production
Description
The Survival of Motor Neurons (SMN) protein participates in RNA splicing. Decreases in SMN, typically a consequence of defects in the smn1 gene, result in the death of motor neurons and lead to the neurodegenerative disease, spinal muscular atrophy (SMA). Cuspin-1 is a small molecule upregulator of SMN that has been shown in vitro to increase levels of SMN in SMA patient fibroblasts by 50% at 18 μM. Its mechanism of action is thought to involve increased phosphorylation of ERK to initiate Ras-Raf-MEK signaling, which results in an increased rate of SMN translation.
Uses
Cuspin 1 is used in cuspin-1 characterization and regulation of SMN protein via Ras signaling in spinal muscular atropy.
Cuspin-1 Preparation Products And Raw materials
Raw materials
Preparation Products
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Cuspin-1 Suppliers
- Tel
- 44-20819178-90 02081917890
- Fax
- (0)2080432064
- info@novachemistry.com
- Country
- United Kingdom
- ProdList
- 4381
- Advantage
- 58