Enrofloxacin

ChemicalBook > CAS DataBase List > Enrofloxacin

Brand Name(s) in US Veterinary fluoroquinolone antimicrobial agents Reasonable compatibility Incompatibility Side effects Precautions Uses

Product Name: Enrofloxacin
CAS No.: 93106-60-6
Chemical Name: Enrofloxacin
Synonyms: ENROFLOXACIN HCL;Enrofloxacine;Enorfloxacin;1,4-dihydro-1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-4-oxo-3-quinoli;Enrofloxacin CRS;Enrofloxacin Impurity 2;Enorofloxacin hydrochloride;1-cyclopropyl-7-(4-ethylpiperazin-1-yl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid;cfpq;Baytri
CBNumber: CB8310192
Molecular Formula: C19H22FN3O3
Formula Weight: 359.39
MOL File: 93106-60-6.mol

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Enrofloxacin Property

Melting point:: 225 °C
Boiling point:: 560.5±50.0 °C(Predicted)
Density: 1.385±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: Chloroform (Slightly), Methanol (Very Slightly, Heated)
pka: 6.43±0.41(Predicted)
form: powder or crystals
color: Pale Yellow to Light Beige
Water Solubility: Soluble in chloroform. Slightly soluble in water. Also soluble in dilute KOH
Merck: 14,3592
BRN: 5307824
CAS DataBase Reference: 93106-60-6(CAS DataBase Reference)
EPA Substance Registry System: 3-Quinolinecarboxylic acid, 1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo- (93106-60-6)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37-24/25
WGK Germany: 3
RTECS: VB1993650
HS Code: 29339900
Hazardous Substances Data: 93106-60-6(Hazardous Substances Data)
Toxicity: LD50 in male, female mice (mg/kg): >5000, 4336 orally; ~200, ~200 i.v.; in male rats, male rabbits (mg/kg): >5000, 500-800 orally (Altreuther)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR1513
Product name: Enrofloxacin
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 500mg
Price: $114
Updated: 2024/03/01

Sigma-Aldrich

Product number: 33699
Product name: Enrofloxacin
Purity: VETRANAL?, analytical standard
Packaging: 100mg
Price: $72.6
Updated: 2024/03/01

Sigma-Aldrich

Product number: 17849
Product name: Enrofloxacin
Purity: ≥99.0%
Packaging: 5G
Price: $161
Updated: 2024/03/01

Sigma-Aldrich

Product number: 17849
Product name: Enrofloxacin
Purity: ≥99.0%
Packaging: 25G
Price: $619
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1235900
Product name: Enrofloxacin
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $436
Updated: 2024/03/01

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Enrofloxacin Chemical Properties,Usage,Production

Brand Name(s) in US

Baytril

Veterinary fluoroquinolone antimicrobial agents

Enrofloxacin and sarafloxacin, danofloxacin, difloxacin, ofloxacin, norfloxacin, orbifloxacin are commonly used third-generation fluoroquinolone broad-spectrum antimicrobial agents in veterinary clinic at present , is ethyl compound of ciprofloxacin, also known as ethyl ciprofloxacin, ethyl ciprofloxacin, norfloxacin, is effective on Gram-negative bacteria, Gram-positive bacteria and mycoplasma, its antibacterial activity is significantly superior to norfloxacin, the effect on mycoplasma is stronger than tylosin and Tiamulin Fumarate. This product is oral, intramuscular and subcutaneous injection, and is easily absorbed, widely distributed in vivo, in addition to the central nervous system, the concentration of the drug in other organizations, almost all are higher than the blood concentration. De ethylation in vivo, mainly produced active metabolite ciprofloxacin, but different among the animals metabolism are larger, birds, dogs, rabbits and cattle body's metabolic rates are high, horses and pigs body's metabolic rates are lower. Clinically Enrofloxacin is used for the treatment of various mycoplasma disease, and respiratory system, digestive system and urogenital system infections, skin infections and sepsis caused by E. coli, Salmonella, Haemophilus, Erysipelas bacillus, Staphylococcus, Streptococcus etc. Especially suitable for mixing infections caused by a variety of bacteria.

Spatial structure formulae diagram of Enrofloxacin
The above information is edited by the chemicalbook of Liu Yujie.

Reasonable compatibility

1. Cooperated application of Enrofloxacin with aminoglycoside (gentamicin), third-generation cephalosporins (cefotaxime, ceftriaxone) and penicillin, colistin, may have synergistic antibacterial effect on certain bacteria (especially Pseudomonas aeruginosa or Enterobacteriaceae), in addition to penicillin-type drugs, due to enhanced toxicity, when in combination, need to reduce the dose, and administered separately.
2. Antibacterial activity of Enrofloxacin combined with apramycin enhanced, showed a synergistic effect. The reason was that antibacterial mechanism of apramycin was to specifically hinder biosynthesis of bacterial protein, and thus achieved effect on inhibiting and killing bacteria, while Enrofloxacin could specifically act on subunit A of bacterial DNA gyrase, inhibiting its activity, affecting DNA melting and sealing chain, both of combination had double blocking effect on bacterial replication and translation process.
3. at the same day were successively mixed to drink with colistin sulfate, can improve the efficacy of Enrofloxacin on chicken bacterial disease. and compatibility with SD silver used for the topical treatment of otitis in dogs.
Reference data: Zheng Hugong, Cui Yaoming editor. reasonable compatibility use of veterinary, Zhengzhou: Henan Science and Technology Press, 2009.

Incompatibility

1. Enrofloxacin can inhibit metabolism of theophylline and caffeine, make the blood concentration increase, thereby causing toxic reactions.
2. Combined with anticholinergic drugs (atropine, 654-2) and H2 receptor antagonists (cimetidine, famotidine), making the bioavailability of Enrofloxacin reduce.
3. Enrofloxacin has a role in inhibiting liver drug enzymes, in combination with drugs metabolized in the liver such as erythromycin, lincomycin, etc. making its clearance decrease, blood concentration increased.
4. antacids may reduce absorption of Enrofloxacin in the gastrointestinal tract, not suitable for simultaneous use.
5. mixed with strongly acidic liquid and the strong alkaline liquid and precipitated.
6. Enrofloxacin and metoclopramide occur chemical changes, easy to turn into muddy, should not be mixed injection.

Side effects

Toxicity of Enrofloxacin is less, safe for clinical use. Therapeutic doses have non-teratogenic and mutagenic effect. Can make young animals cartilage occur turbid, causing lameness and pain. Digestive system reactions are vomiting, abdominal pain and bloating. Skin reactions are erythema, pruritus, urticaria and photosensitivity reactions, etc.

Precautions

1. Enrofloxacin aqueous solution was met with light and easy to change color and decompose, should be kept in dark place.
2. Drug-resistant strains of the product showed an increasing trend, not used at sub-therapeutic doses for long-term.
3. Antacids can inhibit the absorption of this product, should be avoided drinking at the same time.
4. In clinical application, can appropriately adjust dosage based on disease, concentration range of drinking water in poultry, per liter of water, added 25 to 100 mg.
5. withdrawal period of chicken is 8 days. Disabled in egg producing period of laying hen.
6. chicks are very sensitive to Enrofloxacin injection, had many poisoning report, the dose should be strictly controlled.

Uses

1. Antimicrobial, for bacteria and mycoplasma infection.
2. New veterinary antimicrobial drugs, broad-spectrum, high efficiency, has special effects on Gram-positive and Gram-negative bacteria and mycoplasma.

Chemical Properties

Pale Yellow Crystals

Uses

Fluorinated quinolone antibacterial

Uses

Enrofloxacin is a broad spectrum antibiotic bactericidal agent used in veterinary medicine to treat animals afflicted with certain bacterial infections.

Definition

ChEBI: A quinolinemonocarboxylic acid that is 1,4-dihydroquinoline-3-carboxylic acid substituted by an oxo group at position 4, a fluoro group at position 6, a cyclopropyl group at position 1 and a 4-ethylpiperazin-1-yl group at position 7. It is a veterinary ant bacterial agent used for the treatment of pets.

brand name

Baytril (Bayer).

Veterinary Drugs and Treatments

Enrofloxacin is approved for use in dogs and cats (oral only) for the management of diseases associated with bacteria susceptible to enrofloxacin. Because of the dosage restriction (5 mg/kg) for cats, enrofloxacin is generally used in this species only for the most susceptible bacterial infections. It is also been approved for use in cattle (not dairy cattle or veal calves).

Enrofloxacin Preparation Products And Raw materials

Raw materials

Acetophenone

Preparation Products

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View Lastest Price from Enrofloxacin manufacturers

Henan Suikang Pharmaceutical Co.,Ltd.

Product: Enrofloxacin Base 93106-60-6
Price: US $0.00/kg
Min. Order: 25kg
Purity: ＞99.0%
Supply Ability: 10tons
Release date: 2024-04-25

Hebei Zhuanglai Chemical Trading Co Ltd

Product: Enrofloxacin 93106-60-6
Price: US $150.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 500kg
Release date: 2024-11-25

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Enrofloxacin base 93106-60-6
Price: US $0.00/Kg/Drum
Min. Order: 25KG
Purity: 99%min; CVP2015
Supply Ability: 25tons/month
Release date: 2021-06-03

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