3-HYDROXYPHENYLACETIC ACID METHYL ESTER

Product Name: 3-HYDROXYPHENYLACETIC ACID METHYL ESTER
CAS No.: 42058-59-3
Chemical Name: 3-HYDROXYPHENYLACETIC ACID METHYL ESTER
Synonyms: Methyl 2-(3-hydroxyphenyl);Methyl m-hydroxyphenylacetate;METHYL 3-HYDROXYPHENYL ACETATE;Methyl 3-hydroxybenzeneacetate;Methyl 2-(3-hydroxyphenyl)acetate;Methyl 2-(3-hydroxyphenyl)acetate 95%;3-HYDROXYPHENYLACETIC ACID METHYL ESTER;2-(3-Hydroxyphenyl)acetic acid methyl ester;Benzeneacetic acid, 3-hydroxy-, methyl ester
CBNumber: CB8311245
Molecular Formula: C9H10O3
Formula Weight: 166.17
MOL File: 42058-59-3.mol

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3-HYDROXYPHENYLACETIC ACID METHYL ESTER Property

Boiling point:: 146°C/14mmHg(lit.)
Density: 1.181±0.06 g/cm3(Predicted)
refractive index: 1.5340 to 1.5380
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
form: Oil
pka: 9.61±0.10(Predicted)
color: Clear Colourless to Clear Pale Yellow

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Safety

Hazard Codes: Xn
Risk Statements: 22
HS Code: 2918290090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: M2925
Product name: Methyl 3-Hydroxyphenylacetate
Purity: >98.0%(GC)
Packaging: 1g
Price: $52
Updated: 2025/07/31

TCI Chemical

Product number: M2925
Product name: Methyl 3-Hydroxyphenylacetate
Purity: >98.0%(GC)
Packaging: 5g
Price: $179
Updated: 2025/07/31

TRC

Product number: M312785
Product name: Methyl 3-Hydroxyphenylacetate
Packaging: 1g
Price: $45
Updated: 2021/12/16

Oakwood

Product number: 219776
Product name: Methyl2-(3-hydroxyphenyl)acetate
Purity: 95+%
Packaging: 1g
Price: $15
Updated: 2021/12/16

Oakwood

Product number: 219776
Product name: Methyl2-(3-hydroxyphenyl)acetate
Purity: 95+%
Packaging: 25g
Price: $200
Updated: 2021/12/16

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3-HYDROXYPHENYLACETIC ACID METHYL ESTER Chemical Properties,Usage,Production

Uses

Methyl 3-Hydroxyphenylacetate is a phenylacetic acid derivative and a CRTH2 and DP dual antagonist.

Synthesis

67-56-1

621-37-4

42058-59-3

Step 1: 3-Hydroxyphenylacetic acid (15.2 g, 0.1 mol, 1.0 eq.) and concentrated sulfuric acid (392 mg, 4 mmol, 0.04 eq.) were dissolved in methanol (100 mL). The reaction mixture was stirred at room temperature for 1 h. The reaction was subsequently quenched with sodium hydroxide solution. The reaction mixture was extracted with ethyl acetate and the organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate=5:1) to afford methyl 2-(3-hydroxyphenyl)acetate as a yellow oil (14.2 g, 86% yield).1H NMR (400 MHz, CDCl3) δ= 7.15-7.19 (m, 1H), 6.81 (d, 1H), 6.72-6.76 (m, 2H), 5.88 (m, 2H). 2H), 5.88 (s, 1H), 3.70 (s, 3H), 3.58 (s, 2H); LCMS m/z 167 [M + 1]+.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 21, p. 5488 - 5492
[2] Patent: WO2004/63155, 2004, A1. Location in patent: Page 58
[3] Patent: WO2005/66136, 2005, A1. Location in patent: Page/Page column 51
[4] Patent: WO2005/19190, 2005, A2. Location in patent: Page/Page column 51
[5] Patent: WO2005/103050, 2005, A2. Location in patent: Page/Page column 168

3-HYDROXYPHENYLACETIC ACID METHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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3-HYDROXYPHENYLACETIC ACID METHYL ESTER Suppliers

Americas 1 China 95 Europe 1 India 5 Japan 1 Switzerland 1 United Kingdom 3 United States 12 Global 119

Energy Chemical

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View Lastest Price from 3-HYDROXYPHENYLACETIC ACID METHYL ESTER manufacturers

Career Henan Chemical Co

Product: 3-HYDROXYPHENYLACETIC ACID METHYL ESTER 42058-59-3
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 10000KGS
Release date: 2020-01-09

Career Henan Chemical Co

Product: O-AMINOAZOTOLUENE 42058-59-3
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 10000KGS
Release date: 2020-01-09

42058-59-3, 3-HYDROXYPHENYLACETIC ACID METHYL ESTERRelated Search:

Methyl 3,5-dihydroxyphenylacetate METHYL HOMOVERATRATE 3-Methoxyphenylacetic acid ETHYL HOMOVANILLATE 3-HYDROXYPHENYLACETIC ACID METHYL ESTER RESINIFERATOXIN ETHYL 3-METHOXYPHENYLACETATE NOGALAMYCIN ACLARUBICIN HYDROCHLORIDE (2-HYDROXY-PHENYL)-ACETIC ACID METHYL ESTER Methyl cyclohexylphenylglycolate METHYL 2-AMINO-2-(4-HYDROXYPHENYL)ACETATE 4-HYDROXYPHENYLACETIC ACID METHYL ESTER,p-Hydroxyphenylacetic acid methyl ester methyl 2-(3-amino-4-hydroxyphenyl)acetate alpha-Hydroxyphenylacetic acid methyl ester,rac-(R*)-Hydroxyphenylacetic acid methyl ester 3,4-DIHYDROXYPHENYLACETIC ACID METHYL ESTER Methyl cyclopentylphenylglycolate (S)-(+)-ALPHA-HYDROXYPHENYLACETIC ACID METHYL ESTER,(s)-(+)-à-hydroxyphenylacetic acid methyl ester

Benzeneacetic acid, 3-hydroxy-, methyl ester

Methyl m-hydroxyphenylacetate

METHYL 3-HYDROXYPHENYL ACETATE

3-HYDROXYPHENYLACETIC ACID METHYL ESTER

Methyl 2-(3-hydroxyphenyl)acetate

Methyl 3-hydroxybenzeneacetate

2-(3-Hydroxyphenyl)acetic acid methyl ester

Methyl 2-(3-hydroxyphenyl)

Methyl 2-(3-hydroxyphenyl)acetate 95%

42058-59-3

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