(S)-(+)-Methyl mandelate

Product Name: (S)-(+)-Methyl mandelate
CAS No.: 21210-43-5
Chemical Name: (S)-(+)-Methyl mandelate
Synonyms: METHYL L-(+)-MANDELATE;(+)-METHYL L-MANDELATE;METHYL (S)-(+)-MANDELATE;(S)-(+)-METHYL MANDELATE;MethylL-(+)-Mandelate>S-Plus-mandelic acid methyl;(S)-MANDELIC ACID METHYL ESTER;METHYL (S)-(+)-MANDELATE, 99+%;(S)-(+)-Methyl mandelate, 98+%;Methyl (S)-(+)-mandelate, >=98%
CBNumber: CB5345322
Molecular Formula: C9H10O3
Formula Weight: 166.17
MOL File: 21210-43-5.mol

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(S)-(+)-Methyl mandelate Property

Melting point:: 56-58 °C
Boiling point:: 138 °C / 16mmHg
alpha: 142 º (c=2, MeOH)
Density: 1.1097 (rough estimate)
refractive index: 1.4371 (estimate)
Flash point:: >110°C
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Sparingly), Methanol (Sparingly)
form: Solid
pka: 12.19±0.20(Predicted)
color: White to Off-White
optical activity: [α]20/D +144°, c = 1 in methanol
BRN: 2614741
InChIKey: ITATYELQCJRCCK-QMMMGPOBSA-N
CAS DataBase Reference: 21210-43-5(CAS DataBase Reference)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
HS Code: 29181990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 251542
Product name: Methyl (S)-(+)-mandelate
Purity: ≥99%
Packaging: 5g
Price: $70
Updated: 2023/01/07

TCI Chemical

Product number: M1350
Product name: Methyl L-(+)-Mandelate
Purity: >98.0%(GC)
Packaging: 1g
Price: $19
Updated: 2025/07/31

TCI Chemical

Product number: M1350
Product name: Methyl L-(+)-Mandelate
Purity: >98.0%(GC)
Packaging: 5g
Price: $23
Updated: 2025/07/31

TRC

Product number: M317450
Product name: Methyl (S)-(+)-mandelate
Packaging: 5g
Price: $70
Updated: 2021/12/16

Oakwood

Product number: 093736
Product name: Methyl (S)-(+)-mandelate
Purity: 95+%
Packaging: 1g
Price: $10
Updated: 2021/12/16

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(S)-(+)-Methyl mandelate Chemical Properties,Usage,Production

Chemical Properties

white crystalline powder

Uses

Methyl (S)-(+)-Mandelate (cas# 21210-43-5) is a compound useful in organic synthesis.

Uses

Methyl (S)-(+)-mandelate may be used in the preparation of (S)-(-)2-hydroxy-1,2,2-triphenylethyl acetate and (α′S)-α′-methoxycarbonylbenzyl (2S,4R)-(+)-1,2,4,5-tetrahydro-4-methyl-7,8-methylenedioxy-5-oxo-3-benzothiepin-2-carboxylate.

General Description

Optically active building block.

Synthesis

67-56-1

17199-29-0

21210-43-5

GENERAL METHOD: To a stirred solution of 0.1 mol α-acetoxymandelic acid or α-hydroxymandelic acid dissolved in 200 mL of anhydrous methanol at -30°C was slowly added 8.1 mL (13.05 g, 0.11 mol) of thionyl chloride. The reaction solution was continued to be stirred at -30°C for 15 minutes and then moved to room temperature for 48 hours. Upon completion of the reaction, the solvent was removed by concentration under reduced pressure. The residue was adjusted to pH 9 with NaHCO3 solution and subsequently extracted with ether (5 x 50 mL) and the organic phase was dried with MgSO4. After evaporation of the solvent, the resulting (S)-2-hydroxy-2-phenylacetic acid methyl ester crude was purified by either reduced pressure distillation or petroleum ether-toluene mixed solvent crystallization.

References

[1] Patent: JP2005/120020, 2005, A. Location in patent: Page/Page column 9
[2] Angewandte Chemie, International Edition, 2009, vol. 48, # 25, p. 4605 - 4609
[3] Angewandte Chemie, International Edition, 2014, vol. 53, # 37, p. 9860 - 9864,5
[4] Angewandte Chemie, 2014, vol. 126, # 37, p. 10018 - 10022,5
[5] Chemistry Letters, 1997, # 1, p. 55 - 56

(S)-(+)-Methyl mandelate Preparation Products And Raw materials

Raw materials

Sodium chloride Chloroform (S)-(+)-Mandelic acid Methanol Magnesium sulfate Thionyl chloride

Preparation Products

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(S)-(+)-Methyl mandelate Suppliers

Americas 1 Belgium 1 Canada 2 China 146 Europe 1 France 1 Germany 2 India 7 Japan 4 South Korea 1 Switzerland 3 United Kingdom 3 United States 22 Global 194

Zhongshan Haihong Medicine Co. Ltd

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View Lastest Price from (S)-(+)-Methyl mandelate manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: Methyl (2S)-hydroxy(phenyl)acetate 21210-43-5
Price: US $1.10-9.90/KG
Min. Order: 1KG
Purity: 99%min
Supply Ability: 100KG
Release date: 2025-08-20

Honest Joy Holdings Limited

Product: (S)-(+)-Methyl mandelate 21210-43-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99.1%
Supply Ability: 100 tons
Release date: 2022-01-26

Zhuozhou Wenxi import and Export Co., Ltd

Product: (S)-(+)-Methyl mandelate 21210-43-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

21210-43-5, (S)-(+)-Methyl mandelateRelated Search:

Methyl benzoate FATTY ACID METHYL ESTER MIX C8-C22 Methylparaben Mandelic acid Methyl methacrylate Methyl formate (S)-(+)-Mandelic acid Methyl acetate Methyl acrylate METSULFURON METHYL Methyl salicylate Bensulfuron methyl Kresoxim-methyl Thiophanate-methyl Methyl Parathion-methyl Methyl bromide DL-METHYL MANDELATE,(+/-)-METHYL MANDELATE,METHYL MANDELATE

METHYL (S)-(+)-MANDELATE

(+)-METHYL (S)-ALPHA-HYDROXY-PHENYL ACETATE

METHYL (S)-ALPHA-HYDROXYPHENYLACETATE

(+)-METHYL L-MANDELATE

METHYL L-(+)-MANDELATE

(+)-L-MANDELIC ACID METHYL ESTER

L-(+)-MANDELIC ACID METHYL ESTER

S-Plus-mandelic acid methyl

Methyl (<i>S</i>)-(+)-mandelate

Methyl (S)-(+)-mandelate, >=98%

L-Mandelic Acid Methyl Ester,99%e.e.

(S)-(+)-METHYL MANDELATE

(S)-MANDELIC ACID METHYL ESTER

METHYL (S)-(+)-MANDELATE, 99+%

(S)-(+)-alpha-Hydroxyphenylaceticacidmethylester~(S)-(+)-Mandelicacidmethylester

(S)-(+)-ALPHA-HYDROXYPHENYLACETIC ACID METHYL ESTER

(S)-(+)-Methyl mandelate, 98+%

Benzeneacetic acid, .alpha.-hydroxy-, methyl ester, (.alpha.S)-

(+)-methyl (s)-α-hydroxy-phenyl acetate

(+)-methyl (s)-α-hydroxy-phenylacetate

(s)-(+)-à-hydroxyphenylacetic acid methyl ester

(+)-Methyl (S)-alpha-hydroxyphenylacetate

(S)-Methyl 2-hydroxy-2-phenylacetate ,98%

(S)-2-Hydroxy-2-phenylacetic acid methyl ester

(S)-Phenyl(hydroxy)acetic acid methyl ester

(S)-Phenylhydroxyacetic acid methyl ester

[S,(+)]-Phenylglycolic acid methyl ester

[S,(+)]-α-Hydroxybenzeneacetic acid methyl ester

(+)-Methyl (S)-α-hydroxy-phenylacetate, S(+)-Mandelic acid methyl ester

(+)-Methyl (S)-α-hydroxyphenylacetate, (+)-Methyl L-mandelate

(S)-Methyl 2-hydroxy-2-phenylacetate

Methyl (S)-2-Hydroxy-2-phenylacetate

Methyl (S)-α-Hydroxybenzeneacetate

MethylL-(+)-Mandelate&gt

Benzeneacetic acid, α-hydroxy-, methyl ester, (αS)-

(S)-(+)-Methyl mandelate ISO 9001：2015 REACH

Methyl (2S)-hydroxy(phenyl)acetate

21210-43-5

C6H5CHOHCO2CH3

Chiral Resolving Reagents

Chiral Resolution Reagents

Asymmetric Synthesis

Chiral Building Blocks

Esters (Chiral)

Aromatics

Chiral Reagents

Chiral Building Blocks

Esters (Chiral)

Synthetic Organic Chemistry

Chiral Compound