ChemicalBook > CAS DataBase List > MI-136

MI-136

Product Name
MI-136
CAS No.
1628316-74-4
Chemical Name
MI-136
Synonyms
MI-136;CS-2162;MI136;MI 136;HY-19319 (MI 136;MI-136, 10 mM in DMSO;MI-136;HY-19319 (MI 136; MI136);;5-((4-((6-(2,2,2-Trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)methyl)-1H-in;5-[[4-[[6-(2,2,2-Trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]methyl]-1H-indole-2-carbonitrile;5-((4-((6-(2,2,2-Trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)methyl)-1H-indole-2-carbonitrile;1H-Indole-2-carbonitrile, 5-[[4-[[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]methyl]-
CBNumber
CB83121119
Molecular Formula
C23H21F3N6S
Formula Weight
470.51
MOL File
1628316-74-4.mol
More
Less

MI-136 Property

Boiling point:
654.9±55.0 °C(Predicted)
Density 
1.45±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 1 mg/ml; DMSO: 1 mg/ml; Ethanol: 10 mg/ml
form 
A crystalline solid
pka
14.20±0.30(Predicted)
color 
White to off-white
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
19245
Product name
MI-136
Purity
≥98%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
19245
Product name
MI-136
Purity
≥98%
Packaging
5mg
Price
$161
Updated
2024/03/01
Cayman Chemical
Product number
19245
Product name
MI-136
Purity
≥98%
Packaging
10mg
Price
$283
Updated
2024/03/01
Cayman Chemical
Product number
19245
Product name
MI-136
Purity
≥98%
Packaging
25mg
Price
$618
Updated
2024/03/01
ChemScene
Product number
CS-5526
Product name
MI-136
Purity
98.64%
Packaging
5mg
Price
$105
Updated
2021/12/16
More
Less

MI-136 Chemical Properties,Usage,Production

Description

MI-136 is an inhibitor of the menin-MLL interaction (IC50 = 31 nM; Kd = 23.6 nM). By blocking MLL recruitment predominantly at the level of the menin-MLL interaction, it can inhibit androgen receptor (AR)-mediated transcription. At 40 mg/kg, MI-136 has been shown to block AR signaling, inhibiting the growth of castration-resistant tumors in mice.

Uses

MI-136 is an inhibitor of the menin-MLL protein-protein interaction (PPI), with an IC50 of 31 nM and a Kd of 23.6 nM. MI-136 shows to block AR signaling and has the potential for the study in castration-resistant tumors[1][2].

in vivo

MI-136 exhibits T1/2 of 3.1 h after po administration[1].
MI-136 (40 mg/kg, ip) leads to a significant decrease in the growth of castration-resistant VCaP tumors[2].

Animal Model:VCaP xenografts[2].
Dosage:40 mg/kg.
Administration:Intraperitoneal injection, 5 days a week.
Result:Led to a significant decrease in the growth of castration-resistant VCaP tumors compared to vehicle controls.

References

[1] Dmitry Borkin, et al. Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-Protein Interaction between Menin and Mixed Lineage Leukemia (MLL). J Med Chem. 2016 Feb 11;59(3):892-913. DOI:10.1021/acs.jmedchem.5b01305
[2] Rohit Malik, et al. Targeting the MLL complex in castration-resistant prostate cancer. Nat Med. 2015 Apr;21(4):344-52. DOI:10.1038/nm.3830

MI-136 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

MI-136 Suppliers

China 68 India 1 United States 11 Global 80
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
ApexBio Technology
Tel
--
Fax
--
Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80

1628316-74-4, MI-136Related Search:

SAR405838 (MI-773) MI-3 (Menin-MLL Inhibitor) MI-2 (Menin-MLL Inhibitor) CeftazidiMe

  • MI-136
  • MI-136;HY-19319 (MI 136; MI136);
  • HY-19319 (MI 136
  • 1H-Indole-2-carbonitrile, 5-[[4-[[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]methyl]-
  • MI136;MI 136
  • CS-2162
  • 5-[[4-[[6-(2,2,2-Trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]methyl]-1H-indole-2-carbonitrile
  • 5-((4-((6-(2,2,2-Trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)methyl)-1H-in
  • PPI,MI 136,Apoptosis,inhibit,MI136,Inhibitor,CRPC,castration,cancer,resistant,MI-136,Androgen Receptor,Epigenetic Reader Domain,prostate
  • 5-((4-((6-(2,2,2-Trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)methyl)-1H-indole-2-carbonitrile
  • MI-136, 10 mM in DMSO
  • 1628316-74-4
  • C23H21F3N6S