MI-3 (Menin-MLL Inhibitor)
- Product Name
- MI-3 (Menin-MLL Inhibitor)
- CAS No.
- 1271738-59-0
- Chemical Name
- MI-3 (Menin-MLL Inhibitor)
- Synonyms
- MI-3;CS-1809;5-dihydro-5;Menin-MLL inhibitor 3;MI-3 (Menin-MLL Inhibitor);MI-3 (Menin-MLL Inhibitor) USP/EP/BP;5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-(1-methylethyl);MI3,MI-3,Apoptosis,inhibit,Epigenetic Reader Domain,Inhibitor;4-[4-(4,5-Dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-(1-methylethyl)thieno[2,3-d]pyrimidine;Thieno[2,3-d]pyriMidine, 4-[4-(4,5-dihydro-5,5-diMethyl-2-thiazolyl)-1-piperazinyl]-6-(1-Methylethyl)-
- CBNumber
- CB42624233
- Molecular Formula
- C18H25N5S2
- Formula Weight
- 375.55
- MOL File
- 1271738-59-0.mol
MI-3 (Menin-MLL Inhibitor) Property
- Boiling point:
- 527.9±60.0 °C(Predicted)
- Density
- 1.36±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 8.33 mg/mL (22.18 mM; Need ultrasonic)
- form
- Powder
- pka
- 9.59±0.40(Predicted)
N-Bromosuccinimide Price
- Product number
- 27214
- Product name
- MI-3
- Packaging
- 500μg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 27214
- Product name
- MI-3
- Packaging
- 1mg
- Price
- $65
- Updated
- 2024/03/01
- Product number
- 27214
- Product name
- MI-3
- Packaging
- 5mg
- Price
- $231
- Updated
- 2024/03/01
- Product number
- M341040
- Product name
- MI-3(Menin-MLLInhibitor)
- Packaging
- 5mg
- Price
- $185
- Updated
- 2021/12/16
- Product number
- CS-0772
- Product name
- MI-3
- Purity
- 99.73%
- Packaging
- 10mg
- Price
- $252
- Updated
- 2021/12/16
MI-3 (Menin-MLL Inhibitor) Chemical Properties,Usage,Production
Description
MI-3 is an inhibitor of the interaction between menin and mixed lineage leukemia (MLL) fusion proteins (IC50 = 648 nM). MI-3 binds to menin (Kd = 201 nM) and inhibits the menin interaction with the MLL fusion protein MLL-AF9 in HEK293 cells without affecting protein levels of menin or MLL-AF9. It inhibits growth of mouse bone marrow cells (BMCs) expressing the Hoxa9 transformation-dependent MLL fusion proteins MLL-AF9 or MLL-ENL (IC50 = 5 μM for both), as well as reduces colony formation and induces differentiation of MLL-AF9-transformed BMCs. MI-3 inhibits growth of human leukemia cell lines containing MLL translocations and decreases the expression of the transcription factors HOXA9, HOXA10, and MEIS1 in THP-1 cells.
Uses
MI-3 (Menin-MLL Inhibitor) reverses oncogenic activity of MLL fusion proteins in leukemia.
MI-3 (Menin-MLL Inhibitor) Preparation Products And Raw materials
Raw materials
Preparation Products
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