MI-3 (Menin-MLL Inhibitor)

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MI-3 (Menin-MLL Inhibitor)

Product Name: MI-3 (Menin-MLL Inhibitor)
CAS No.: 1271738-59-0
Chemical Name: MI-3 (Menin-MLL Inhibitor)
Synonyms: MI-3;CS-1809;5-dihydro-5;Menin-MLL inhibitor 3;MI-3 (Menin-MLL Inhibitor);MI-3 (Menin-MLL Inhibitor) USP/EP/BP;5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-(1-methylethyl);MI3,MI-3,Apoptosis,inhibit,Epigenetic Reader Domain,Inhibitor;4-(4-(5,5-Dimethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)-6-isopropylthieno[2,3-d]pyrimidine;4-[4-(4,5-Dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-(1-methylethyl)thieno[2,3-d]pyrimidine
CBNumber: CB42624233
Molecular Formula: C18H25N5S2
Formula Weight: 375.55
MOL File: 1271738-59-0.mol

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MI-3 (Menin-MLL Inhibitor) Property

Boiling point:: 527.9±60.0 °C(Predicted)
Density: 1.36±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 8.33 mg/mL (22.18 mM; Need ultrasonic)
form: Powder
pka: 9.59±0.40(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 27214
Product name: MI-3
Packaging: 500μg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 27214
Product name: MI-3
Packaging: 1mg
Price: $65
Updated: 2024/03/01

Cayman Chemical

Product number: 27214
Product name: MI-3
Packaging: 5mg
Price: $231
Updated: 2024/03/01

TRC

Product number: M341040
Product name: MI-3(Menin-MLLInhibitor)
Packaging: 5mg
Price: $185
Updated: 2021/12/16

ChemScene

Product number: CS-0772
Product name: MI-3
Purity: 99.73%
Packaging: 10mg
Price: $252
Updated: 2021/12/16

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MI-3 (Menin-MLL Inhibitor) Chemical Properties,Usage,Production

Description

MI-3 is an inhibitor of the interaction between menin and mixed lineage leukemia (MLL) fusion proteins (IC₅₀ = 648 nM). MI-3 binds to menin (K_d = 201 nM) and inhibits the menin interaction with the MLL fusion protein MLL-AF9 in HEK293 cells without affecting protein levels of menin or MLL-AF9. It inhibits growth of mouse bone marrow cells (BMCs) expressing the Hoxa9 transformation-dependent MLL fusion proteins MLL-AF9 or MLL-ENL (IC₅₀ = 5 μM for both), as well as reduces colony formation and induces differentiation of MLL-AF9-transformed BMCs. MI-3 inhibits growth of human leukemia cell lines containing MLL translocations and decreases the expression of the transcription factors HOXA9, HOXA10, and MEIS1 in THP-1 cells.

Uses

MI-3 (Menin-MLL Inhibitor) reverses oncogenic activity of MLL fusion proteins in leukemia.

MI-3 (Menin-MLL Inhibitor) Preparation Products And Raw materials

Raw materials

Preparation Products

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1271738-59-0, MI-3 (Menin-MLL Inhibitor)Related Search:

MI-136 SAR405838 (MI-773) MI-2 (Menin-MLL Inhibitor) Tazemetostat (EPZ-6438) ACY-1215 Panobinostat (2R,3R,4S,5R)-2-(6-aMino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]iMidazol-2-yl)ethyl)cyclobutyl)(isopropyl)aMino)Methyl)tetrahydrofuran-3,4-diol I-BET-762 OG-L002

MI-3

5-dihydro-5

5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-(1-methylethyl)

MI3;MI 3;MENIN-MLL INHIBITOR 3;THIENO[2;3-D]PYRIMIDINE; 4-[4-(4;5-DIHYDRO-5;5-DIMETHYL-2-THIAZOLYL)-1-PIPERAZINYL]-6-(1-METHYLETHYL)

Menin-MLL inhibitor 3

Thieno[2,3-d]pyriMidine, 4-[4-(4,5-dihydro-5,5-diMethyl-2-thiazolyl)-1-piperazinyl]-6-(1-Methylethyl)-

4-[4-(4,5-Dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-(1-methylethyl)thieno[2,3-d]pyrimidine

MI-3 (Menin-MLL Inhibitor)

4-[4-(4,5-Dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-(1-methylethyl)thieno[2,3-d]pyrimidine MI-3

CS-1809

MI-3 (Menin-MLL Inhibitor) USP/EP/BP

MI3,MI-3,Apoptosis,inhibit,Epigenetic Reader Domain,Inhibitor

4-(4-(5,5-Dimethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)-6-isopropylthieno[2,3-d]pyrimidine

1271738-59-0

Inhibitors