Isobutyric acid hydrazide
Application- Product Name
- Isobutyric acid hydrazide
- CAS No.
- 3619-17-8
- Chemical Name
- Isobutyric acid hydrazide
- Synonyms
- AKOS B015435;ISOBUTYLVINYLETHER;ISOBUTYROHYDRAZIDE;CHEMBRDG-BB 3015435;isobutyrylhydrazide;ART-CHEM-BB B015435;1-Isobutyrylhydrazine;SPECS AE-848/30741004;ISOBUTYRIC ACID HYDRAZIDE;2-methylpropionohydrazide
- CBNumber
- CB8312116
- Molecular Formula
- C4H10N2O
- Formula Weight
- 102.14
- MOL File
- 3619-17-8.mol
Isobutyric acid hydrazide Property
- Melting point:
- 97 °C
- Boiling point:
- 238.6±9.0 °C(Predicted)
- Density
- 0.976±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 13.46±0.36(Predicted)
- color
- White to Almost white
- CAS DataBase Reference
- 3619-17-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,T
- Risk Statements
- 20/21/22-36/37/38-25
- Safety Statements
- 26-36/37/39-45
- RIDADR
- UN2811
- RTECS
- NQ4700000
- HS Code
- 2928.00.5000
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- I1105
- Product name
- Isobutyric Acid Hydrazide
- Packaging
- 5G
- Price
- $205
- Updated
- 2025/07/31
- Product number
- I1105
- Product name
- Isobutyric Acid Hydrazide
- Packaging
- 25G
- Price
- $673
- Updated
- 2025/07/31
- Product number
- I789203
- Product name
- Isobutyric Acid Hydrazide
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- I789203
- Product name
- Isobutyric Acid Hydrazide
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- I789203
- Product name
- Isobutyric Acid Hydrazide
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
Isobutyric acid hydrazide Chemical Properties,Usage,Production
Application
Isobutyryl hydrazine can be used as a pharmaceutical synthesis intermediate. Examples of its applications are as follows:
1) Preparation of 3-isopropyl-4-amino-1,2,4-triazolin-5-one, comprising: Step 1, reacting isobutyric acid and hydrazine hydrate in n-butanol solvent at a reaction temperature of 50–150°C to generate isobutyryl hydrazine; Step 2, reacting the isobutyryl hydrazine reaction solution synthesized in Step 1 with phosgene or solid-phase phosgene and n-butanol as a solvent at a reaction temperature of 0–60°C to generate butyl 2-isobutylhydrazine carbamate; Step 3, reacting the butyl 2-isobutylhydrazine carbamate synthesized in Step 2 with hydrazine hydrate in an alkaline solution at a reaction temperature of 80–120°C to generate 3-isopropyl-4-amino-1,2,4-triazolin-5-one and n-butanol. This invention uses n-butanol as the solvent throughout the entire reaction process, without separation in the intermediate steps. It boasts advantages such as a simple reaction system, fast reaction rate, low waste volume, reusable n-butanol, and a high yield of up to 85%.
2) Preparation of a new class of indole derivatives. Using derivatives of indole-3-carboxaldehyde and isobutyrylhydrazine as raw materials, anticancer active groups such as -OCH3 and -C=N-NH-C=O are introduced, either wholly or partially, into appropriate positions of indole through chemical reactions to obtain a series of indole compounds containing multiple functional groups. This process is simple to operate, has mild reaction conditions, and high yield. Furthermore, these compounds exhibit good biological activity and can be used to treat tumors, showing broad application prospects in the pharmaceutical field.
Synthesis
97-62-1
3619-17-8
Ethyl isobutyrate (58.0 g, 0.5 mol) was used as a raw material and reacted with an excess of 50% hydrazine hydrate (110 mL) under reflux conditions for 7 hours. After completion of the reaction, the solvent was removed by vacuum distillation and the crude product was purified by ethanol recrystallization to give isobutyrylhydrazine (3) in 65.6% yield.
References
[1] Medicinal Chemistry, 2013, vol. 9, # 7, p. 968 - 973
[2] Patent: WO2016/127859, 2016, A1. Location in patent: Paragraph 00233
[3] Journal fuer Praktische Chemie (Leipzig), 1930, vol. <2>125, p. 176
[4] Journal fuer Praktische Chemie (Leipzig), 1904, vol. <2>69, p. 498
[5] European Journal of Medicinal Chemistry, 1990, vol. 25, # 1, p. 75 - 79
Isobutyric acid hydrazide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Isobutyric acid hydrazide manufacturers
- Product
- Isobutyric acid hydrazide 3619-17-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20t
- Release date
- 2024-07-15
- Product
- Isobutyric acid hydrazide 3619-17-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-07-03