CP21R7(CP21)

Product Name: CP21R7(CP21)
CAS No.: 125314-13-8
Chemical Name: CP21R7(CP21)
Synonyms: CP21R7;CS-2352;CP21R7(CP21);CP21 (CP21R7);3-(3-aminophenyl)-4-(1-methyl-3-indolyl)-1H-pyrrole-2,5-dione;3-(3-Aminophenyl)-4-(1-methyl-1H-indol-3-yl)pyrrole-2,5-dione;3-(3-aminophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione;1H-Pyrrole-2,5-dione, 3-(3-aminophenyl)-4-(1-methyl-1H-indol-3-yl)-
CBNumber: CB83122439
Molecular Formula: C19H15N3O2
Formula Weight: 317.34
MOL File: 125314-13-8.mol

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CP21R7(CP21) Property

Boiling point:: 627.4±55.0 °C(Predicted)
Density: 1.37±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: insoluble in EtOH; insoluble in H2O; ≥14.25 mg/mL in DMSO
form: crystalline solid
pka: 7.79±0.60(Predicted)
color: Yellow to orange

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 20573
Product name: CP21R7
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 20573
Product name: CP21R7
Purity: ≥98%
Packaging: 5mg
Price: $172
Updated: 2024/03/01

Cayman Chemical

Product number: 20573
Product name: CP21R7
Purity: ≥98%
Packaging: 10mg
Price: $299
Updated: 2024/03/01

Cayman Chemical

Product number: 20573
Product name: CP21R7
Purity: ≥98%
Packaging: 25mg
Price: $586
Updated: 2024/03/01

TRC

Product number: C781150
Product name: CP21R7
Packaging: 25mg
Price: $825
Updated: 2021/12/16

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CP21R7(CP21) Chemical Properties,Usage,Production

Uses

CP21R7 is a potent and selective inhibitor of GSK3β.

Biological Activity

cp21r7 is a potent and selective inhibitor of gsk3β.the glycogen synthase kinase-3β (gsk-3β), a serine/threonine, is a ubiquitous kinase that participates in a multitude of cellular processes, such as cell membrane-to-nucleus signaling, gene transcription, translation, cytoskeletal structuring and cell cycle progression and survival [1].

in vitro

cp21r7 was an inhibitor of gsk3β and pkcα with the ic50 values of 1.8 and 1900 nm, respectively [1]. in the human reporter cell line, cp21r7 potently activated canonical wnt signallingeven at the dose of 1 μm, with highest activity seen at 3 μm [2]. in human ipscs exposed to n2b27 medium, supplemented with 1 μm gsk3β inhibitor cp21r7 strongly upregulated the expression of t (also known as brachyury, t/bry), a meso-endoderm marker expressed in the primitive streak [2].

References

[1] gong l, hirschfeld d, tan y c, et al. discovery of potent and bioavailable gsk-3β inhibitors[j]. bioorganic & medicinal chemistry letters, 2010, 20(5): 1693-1696.
[2] ciampi o, iacone r, longaretti l, et al. generation of functional podocytes from human induced pluripotent stem cells[j]. stem cell research, 2016, 17(1): 130-139.

CP21R7(CP21) Preparation Products And Raw materials

Raw materials

Preparation Products

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CP21R7(CP21) Suppliers

China 78 India 1 United Kingdom 1 United States 11 Global 91

Carbosynth

Tel: --
Fax: --
Email: sales@carbosynth.com
Country: United Kingdom
ProdList: 6005
Advantage: 58

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View Lastest Price from CP21R7(CP21) manufacturers

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: CP21R7 125314-13-8
Price: US $100.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2021-09-13

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: CP21R7 125314-13-8
Price: US $100.00/Kg/Bag
Min. Order: 1KG
Purity: 99%
Supply Ability: 10kg
Release date: 2021-09-15

Career Henan Chemical Co

Product: 3-(3-aminophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione 125314-13-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2019-12-18

125314-13-8, CP21R7(CP21)Related Search:

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3-(3-Aminophenyl)-4-(1-methyl-1H-indol-3-yl)pyrrole-2,5-dione

CP21R7(CP21)

CP21R7

3-(3-aminophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione

CS-2352

CP21 (CP21R7)

3-(3-aminophenyl)-4-(1-methyl-3-indolyl)-1H-pyrrole-2,5-dione

1H-Pyrrole-2,5-dione, 3-(3-aminophenyl)-4-(1-methyl-1H-indol-3-yl)-

125314-13-8