(2R,4R)-APDC

Product Name: (2R,4R)-APDC
CAS No.: 169209-63-6
Chemical Name: (2R,4R)-APDC
Synonyms: 4R)-APDC;LY-314,593;(2R,4R)-APDC;2R, 4R-APDC monohydrate;(2R,4R)APDC,(2R,4R) APDC;4-amino-2,4-pyrrolidinedicarboxylic acid;(2R,4R)-4-AMINOPYRROLIDINE-2,4-DICARBOXYLATE;(2R,4R)-4-AMINOPYRROLIDINE-2,4-DICARBOXYLIC ACID;2,4-Pyrrolidinedicarboxylic acid, 4-amino-, (2R,4R)-;2,4-Pyrrolidinedicarboxylicacid,4-amino-,(2R,4R)-(9CI)
CBNumber: CB5772407
Molecular Formula: C6H10N2O4
Formula Weight: 174.15
MOL File: 169209-63-6.mol

More

Less

(2R,4R)-APDC Property

storage temp.: Desiccate at RT
solubility: H2O: ≥2mg/mL
form: powder
color: white
Water Solubility: Soluble to 100 mM in water

More

Less

Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 26
WGK Germany: 3

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Tocris

Product number: 1208
Product name: (2R,4R)-APDC
Purity: ≥98%(HPLC)
Packaging: 10
Price: $255
Updated: 2021/12/16

Tocris

Product number: 1208
Product name: (2R,4R)-APDC
Purity: ≥98%(HPLC)
Packaging: 50
Price: $1071
Updated: 2021/12/16

TRC

Product number: A726238
Product name: (2R,4R)-APDC
Packaging: 1mg
Price: $65
Updated: 2021/12/16

TRC

Product number: A726238
Product name: (2R,4R)-APDC
Packaging: 2.5mg
Price: $130
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CCH0001246
Product name: (2R,4R)-APDC
Purity: 95.00%
Packaging: 1MG
Price: $202.65
Updated: 2021/12/16

More

Less

(2R,4R)-APDC Chemical Properties,Usage,Production

Uses

(2R,4R)-APDC is a potent and selective group II metabotropic glutamate receptor agonist (1,2). It has been shown that (2R,4R)-APDC decrease cell proliferation in the dentate gyrus of adult rats (1).

Definition

ChEBI: (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid is a pyrrolidinedicarboxylic acid.

Biological Activity

A highly selective and relatively potent group II metabotropic glutamate receptor agonist. EC 50 values are 0.4, 0.4, > 100, > 100, > 300 and > 300 μ M for human mGlu 2 , mGlu 3 , mGlu 1 , mGlu 5 , mGlu 4 and mGlu 7 receptors respectively. Centrally active following systemic administration in vivo . Also available as part of the Group II mGlu Receptor Tocriset™ .

in vitro

2r,4r-apdc blocked forskolin-stimulated camp with none of the other activities of ls,3r-acpd. forskolin-stimulated camp formation in human mglur2 expressing cells with about three-fold greater potency than ls,3r-acpd were also inhibited by 2r,4r-apdc, which, unlike ls,3r-acpd, exhibited no appreciable activation of phosphoinostide hydrolysis in human mglur. thus, 2r,4r-apdc should be a useful pharmacological tool to explore the functions of mglurs coupled to inhibition of adenylate cyclase [1]. the effects of four isomers of apdc were investigated at glutamate receptors in vitro. (2r,4r)-apdc, an aza analog of the nonselective mglur agonist (1s,3r)-acpd possessed relatively high affinity for metabotropic glutamate receptors (mglurs) with no effects on radioligand binding to nmda, ampa, or kainate receptors up to 100 ím. none of the other apdc isomers exhibited significant mglur binding affinity, indicating that this interaction is highly stereospecific [2].

in vivo

both (1s,3r)-acpd and (2r,4r)-apdc were effectively attenuating forskolin-stimulated camp formation in the adult rat cerebral cortex; however, while (1s,3r)-acpd was also effectively stimulating basal tritiated inositol monophosphate production of the neonatal rat cerebral cortex, (2r,4r)-apdc was not effectively stimulating phosphoinositide hydrolysis in this tissue preparation. an augmentation of ampa-induced excitation was produced by microelectrophoretic application of either (1s,3r)-acpd or (2r,4r)-apdc to intact rat spinal neurons [2].

storage

Desiccate at RT

References

[1] schoepp dd, johnson bg, salhoff cr, valli mj, desai ma, burnett jp, mayne ng, monn ja. selective inhibition of forskolin-stimulated cyclic amp formation in rat hippocampus by a novel mglur agonist, 2r,4r-4-aminopyrrolidine-2,4- dicarboxylate. neuropharmacology. 1995 aug;34(8):843-50.
[2] monn ja, valli mj, johnson bg, salhoff cr, wright ra, howe t, bond a, lodge d, spangle la, paschal jw, campbell jb, griffey k, tizzano jp, schoepp dd. synthesis of the four isomers of 4-aminopyrrolidine-2,4-dicarboxylate: identification of a potent, highly selective, and systemically-active agonist for metabotropic glutamate receptors negatively coupled to adenylate cyclase. j med chem. 1996 jul 19; 39 (15):2990-3000.

(2R,4R)-APDC Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

(2R,4R)-APDC Suppliers

China 32 Czech 1 Europe 2 Germany 2 India 1 Japan 1 Switzerland 2 Ukraine 1 United Kingdom 2 United States 12 USA 1 Global 57

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
Advantage: 60

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Shanghai Han-Xiang Chemical Co., Ltd.

Tel: 15971444841
Fax: 18327183813
Email: amber@biochempartner.com
Country: China
ProdList: 3061
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32063
Advantage: 58

Jinan ponder chemical co. LTD

Tel: 0531-0000
Email: thinklifescience@163.com
Country: China
ProdList: 19689
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44808
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29774
Advantage: 58

169209-63-6, (2R,4R)-APDCRelated Search:

1-Pyrrolidinecarbodithioic acid ammonium salt, Ammonium pyrrolidinecarbodithioate, APDC, PDC, PDTC,APDC AMMONIUM SALT,APDC (S)-Pyrrolidin-3-ylmethanol (R)-3-Aminopyrrolidine D-2,3-Diaminopropionic acid D-SS-(N-METHYLAMINO)ALANINE 3-Aminopyrrolidine-3-carboxylic acid DL-2-METHYLGLUTAMIC ACID (R)-3-AMINO-PYRROLIDINE-3-CARBOXYLIC ACID 3-Pyrrolidinecarboxylic acid 2-AMINO-2-METHYL-5-HYDROXY-PENTANOIC ACID (2R,4R)-APDC 2,4-DIAMINO-2-METHYL-BUTYRIC ACID DL-2,4-Diaminoglutaric acid 2,4-PYRROLIDINEDICARBOXYLIC ACID 1-BENZYL-APDC.HCL, >98% Ammoniumpyrrolidinedithiocarbamate(apdc)80%extrapure 2-[(2-amino-2-methyl-propyl)amino]ethanol 1-BENZYL-APDC HCL,1-BENZYL-APDC HYDROCHLORIDE

LY-314,593

2,4-Pyrrolidinedicarboxylicacid,4-amino-,(2R,4R)-(9CI)

(2R,4R)-APDC

(2R,4R)-4-AMINOPYRROLIDINE-2,4-DICARBOXYLATE

(2R,4R)-4-AMINOPYRROLIDINE-2,4-DICARBOXYLIC ACID

2R, 4R-APDC monohydrate

4-amino-2,4-pyrrolidinedicarboxylic acid

2,4-Pyrrolidinedicarboxylic acid, 4-amino-, (2R,4R)-

4R)-APDC

(2R,4R)APDC,(2R,4R) APDC

169209-63-6

PYRROLE