(S)-Pyrrolidin-3-ylmethanol
- Product Name
- (S)-Pyrrolidin-3-ylmethanol
- CAS No.
- 110013-19-9
- Chemical Name
- (S)-Pyrrolidin-3-ylmethanol
- Synonyms
- L-β-Prolinol;L-beta-Prolinol;L-^b-Prolinol, 95%;(S)-3-(HydroxymethyL;(S)-BETA-PROLINOL HCL;(S)-3-Pyrrolidin-Methanol;(S)-3-Pyrrolidinemethanol;(3S)-3-Pyrrolidinemethanol;3-Pyrrolidinemethanol, (S)-;(s)-pyrrolidin-3-ylmethanol
- CBNumber
- CB01267606
- Molecular Formula
- C5H11NO
- Formula Weight
- 101.15
- MOL File
- 110013-19-9.mol
(S)-Pyrrolidin-3-ylmethanol Property
- Melting point:
- 174-176℃
- Boiling point:
- 176 °C
- Density
- 0.978
- Flash point:
- 90 °C
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 14.93±0.10(Predicted)
- Appearance
- Colorless to off-white Solid-liquid mixture
- optical activity
- Consistent with structure
- Water Solubility
- Slightly soluble in water
- Sensitive
- Hygroscopic
- CAS DataBase Reference
- 110013-19-9
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- P999055
- Product name
- (S)-Pyrrolidin-3-ylmethanol
- Packaging
- 250mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- 300344
- Product name
- (S)-Pyrrolidin-3-ylmethanol, 96%
- Packaging
- 250mg
- Price
- $93.5
- Updated
- 2021/12/16
- Product number
- AS22854
- Product name
- (S)-3-(Hydroxymethyl)pyrrolidine
- Purity
- 95+% ee
- Packaging
- 1g
- Price
- $168
- Updated
- 2021/12/16
- Product number
- OR309159
- Product name
- [S]-3-Pyrrolidinemethanol
- Packaging
- 1g
- Price
- $193
- Updated
- 2021/12/16
- Product number
- AS22854
- Product name
- (S)-3-(Hydroxymethyl)pyrrolidine
- Purity
- 95+% ee
- Packaging
- 5G
- Price
- $478
- Updated
- 2021/12/16
(S)-Pyrrolidin-3-ylmethanol Chemical Properties,Usage,Production
Uses
(S)-Pyrrolidin-3-ylmethanol is used in the preparation of pyridoindoles as kinase inhibiting compounds useful in treatment and prevention of kinase-associated diseases.
Synthesis
35309-35-4
85310-69-6
General procedure for the synthesis of 3-pyrrolidinemethanol from methyl 5-oxopyrrolidine-3-carboxylate: 2 kg of methyl 5-oxo-3-pyrrolidinecarboxylate was dissolved in 20 liters of tetrahydrofuran, and 1.9 kg of sodium borohydride was added in batches at room temperature. Subsequently, 3.9 kg of boron trifluoride ether solution was slowly added dropwise. After the dropwise addition, the reaction mixture was stirred at room temperature for 10 minutes and then heated to reflux for about 4 hours. After completion of the reaction, the reaction was quenched with water, extracted with ethyl acetate and concentrated to give a light yellow oily liquid. This oily liquid was dissolved in ethanol, 500 g of sodium borohydride was added and the reaction was refluxed for 2 hours. The reaction was quenched with water again, extracted with ethyl acetate, and the organic phase was washed with saturated aqueous sodium bicarbonate and saturated brine in turn, and finally the organic phase was concentrated to obtain 1.2 kg of 3-pyrrolidinylmethanol with a yield of 86%.
References
[1] Patent: CN106588738, 2017, A. Location in patent: Paragraph 0032; 0034; 0039; 0042; 0044
(S)-Pyrrolidin-3-ylmethanol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (S)-Pyrrolidin-3-ylmethanol manufacturers
- Product
- (S)-Pyrrolidin-3-ylmethanol 110013-19-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-08
- Product
- (S)-Pyrrolidin-3-ylmethanol 110013-19-9
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-07