platyphylline

Product Name: platyphylline
CAS No.: 480-78-4
Chemical Name: platyphylline
Synonyms: Platifillin;Platiphyllin;Platiphillin;Platyphyllin;platyphylline;Einecs 207-558-6;66641-38-1 (Hydrochloride);PLATYPHYLLINI HYDROTARTRAS;12-Hydroxy-1,2-dihydrosenecionan-11,16-dione;(1R)-1,2-Dihydro-12-hydroxysenecionan-11,16-dione
CBNumber: CB3914285
Molecular Formula: C18H27NO5
Formula Weight: 337.41
MOL File: 480-78-4.mol

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platyphylline Property

Melting point:: 129°
alpha: D20 -56.4° (c = 0.7 in chloroform)
Boiling point:: 539.6±50.0 °C(Predicted)
Density: 1.22±0.1 g/cm3(Predicted)
pka: 12.83±0.40(Predicted)

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Safety

RIDADR: 1544
HazardClass: 6.1(b)
PackingGroup: III

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Matrix Scientific

Product number: 059765
Product name: 12-Hydroxy-1,2-dihydrosenecionan-11,16-dione
Packaging: 500mg
Price: $199
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0016155
Product name: PLATYPHYLLINE
Purity: 95.00%
Packaging: 1G
Price: $232.05
Updated: 2021/12/16

Matrix Scientific

Product number: 059765
Product name: 12-Hydroxy-1,2-dihydrosenecionan-11,16-dione
Packaging: 1g
Price: $306
Updated: 2021/12/16

Matrix Scientific

Product number: 059765
Product name: 12-Hydroxy-1,2-dihydrosenecionan-11,16-dione
Packaging: 5g
Price: $1071
Updated: 2021/12/16

Arctom

Product number: CFN00403
Product name: Platyphylline
Purity: ≥98%
Packaging: 5mg
Price: $468
Updated: 2021/12/16

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platyphylline Chemical Properties,Usage,Production

Description

A hepatotoxic alkaloid, the base has been isolated from Senecio adnatus D.C., S. hygrophilus Dyer & Sm. and S. piatyphyllus D.C. The alkaloid is only sparingly soluble in petroleum ether or hot H20, more so in Me2CO, EtOH, C6H6 or Et20 and readily soluble in CHCI3. It is laevorotatory with [α]_D - 45.09° (CHCI3). The perchlorate occurs as colourless prisms from H20, m.p. 222-3°C (dec.); the picrolonate, dark yellow needles, m.p. 205-6°C (dec.); aurichloride, m.p. 200-loC (dec.) and the methiodide, m.p. 216-7°C; [α]_D - 31.27° (EtOH). The alkaloid contains one hydroxyl group but no methoxyl or methylimino groups. On hydrolysis it furnishes platynecine, CSH1S0 2N, m.p. 148°C; [α]_D - 56.8° (CHCI3) and platynecic acid, ClOH140 4 , m.p. l54-5°C which is identical with senecic acid lactone.

Uses

12-Hydroxy-1,2-dihydrosenecionan-11,16-dione is a pyrrolizidine alkaloid which can be found in various Senecio species. It can be useful in the generation and characterization of monoclonal antibodies against the pyrrolizidine alkaloid retrorsine .

Definition

ChEBI: Platyphylline is a macrolide.

References

Orekhov, Tiedebel., Ber., 68,653 (1935)
Orekhov, Konovalova, Tiedebel., ibid, 68, 1886 (1935)
Orekhov, Tiedebel., J. Gen. Chern. USSR, 8,273 (1938)
de Waal., Onderstepoort J., 15,251 (1940)
Koekemoer, Warren., J. Chern. Soc., 63 (1955)

platyphylline Preparation Products And Raw materials

Raw materials

Preparation Products

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platyphylline Suppliers

China 17 India 1 Russia 1 United States 3 Global 22

J & K SCIENTIFIC LTD.

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platyphylline

(1R)-1,2-Dihydro-12-hydroxysenecionan-11,16-dione

[1R,(-)]-1,2-Dihydro-12-hydroxysenecionan-11,16-dione

Platifillin

(1-alpha)-1,2-Dihydro-12-hydroxysenecionan-11,16-dione

66641-38-1 (Hydrochloride)

Einecs 207-558-6

Platiphillin

Platiphyllin

Senecionan-11,16-dione, 1,2-dihydro-12-hydroxy-, (1-alpha)-

12-Hydroxy-1,2-dihydrosenecionan-11,16-dione

Platyphyllin

[1,6]Dioxacyclododecino[2,3,4-gh]pyrrolizine-2,7-dione, 3-ethylidenedodecahydro-6-hydroxy-5,6-dimethyl-, (3Z,5R,6R,9aS,14aR,14bR)-

PLATYPHYLLINI HYDROTARTRAS

480-78-4