platyphylline

Product Name: platyphylline
CAS No.: 480-78-4
Chemical Name: platyphylline
Synonyms: Platifillin;Platiphyllin;Platiphillin;Platyphyllin;platyphylline;Einecs 207-558-6;66641-38-1 (Hydrochloride);PLATYPHYLLINI HYDROTARTRAS;12-Hydroxy-1,2-dihydrosenecionan-11,16-dione;(1R)-1,2-Dihydro-12-hydroxysenecionan-11,16-dione
CBNumber: CB3914285
Molecular Formula: C18H27NO5
Formula Weight: 337.41
MOL File: 480-78-4.mol

More

Less

platyphylline Property

Melting point:: 129°
alpha: D20 -56.4° (c = 0.7 in chloroform)
Boiling point:: 539.6±50.0 °C(Predicted)
Density: 1.22±0.1 g/cm3(Predicted)
pka: 12.83±0.40(Predicted)

More

Less

Safety

RIDADR: 1544
HazardClass: 6.1(b)
PackingGroup: III

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Matrix Scientific

Product number: 059765
Product name: 12-Hydroxy-1,2-dihydrosenecionan-11,16-dione
Packaging: 500mg
Price: $199
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0016155
Product name: PLATYPHYLLINE
Purity: 95.00%
Packaging: 1G
Price: $232.05
Updated: 2021/12/16

Matrix Scientific

Product number: 059765
Product name: 12-Hydroxy-1,2-dihydrosenecionan-11,16-dione
Packaging: 1g
Price: $306
Updated: 2021/12/16

Matrix Scientific

Product number: 059765
Product name: 12-Hydroxy-1,2-dihydrosenecionan-11,16-dione
Packaging: 5g
Price: $1071
Updated: 2021/12/16

Arctom

Product number: CFN00403
Product name: Platyphylline
Purity: ≥98%
Packaging: 5mg
Price: $468
Updated: 2021/12/16

More

Less

platyphylline Chemical Properties,Usage,Production

Description

A hepatotoxic alkaloid, the base has been isolated from Senecio adnatus D.C., S. hygrophilus Dyer & Sm. and S. piatyphyllus D.C. The alkaloid is only sparingly soluble in petroleum ether or hot H20, more so in Me2CO, EtOH, C6H6 or Et20 and readily soluble in CHCI3. It is laevorotatory with [α]_D - 45.09° (CHCI3). The perchlorate occurs as colourless prisms from H20, m.p. 222-3°C (dec.); the picrolonate, dark yellow needles, m.p. 205-6°C (dec.); aurichloride, m.p. 200-loC (dec.) and the methiodide, m.p. 216-7°C; [α]_D - 31.27° (EtOH). The alkaloid contains one hydroxyl group but no methoxyl or methylimino groups. On hydrolysis it furnishes platynecine, CSH1S0 2N, m.p. 148°C; [α]_D - 56.8° (CHCI3) and platynecic acid, ClOH140 4 , m.p. l54-5°C which is identical with senecic acid lactone.

Uses

12-Hydroxy-1,2-dihydrosenecionan-11,16-dione is a pyrrolizidine alkaloid which can be found in various Senecio species. It can be useful in the generation and characterization of monoclonal antibodies against the pyrrolizidine alkaloid retrorsine .

Definition

ChEBI: Platyphylline is a macrolide.

References

Orekhov, Tiedebel., Ber., 68,653 (1935)
Orekhov, Konovalova, Tiedebel., ibid, 68, 1886 (1935)
Orekhov, Tiedebel., J. Gen. Chern. USSR, 8,273 (1938)
de Waal., Onderstepoort J., 15,251 (1940)
Koekemoer, Warren., J. Chern. Soc., 63 (1955)

platyphylline Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

platyphylline Suppliers

China 17 India 1 Russia 1 United States 3 Global 22

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7887
Advantage: 56

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15178
Advantage: 58

Wuhan ChemFaces Biochemical Co., Ltd.

Tel: 18607101326 15172504745
Fax: +86-27-84254680
Email: aileen@chemfaces.com
Country: China
ProdList: 6905
Advantage: 55

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57423
Advantage: 58

AFINE CHEMICALS LIMITED

Tel: +86-0571-85134551
Fax: 008657185134895
Email: sales@afinechem.com
Country: China
ProdList: 15352
Advantage: 58

Wuxi Helen Biotechnology Co., Ltd.,

Tel: 0510-85629785 18013409632
Fax: 0510-85625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 14081
Advantage: 58

Shanghai Hewu Biotechnology Co., LTD

Tel: 021-57886085 17317861055
Email: shhebio@126.com
Country: CHINA
ProdList: 7974
Advantage: 58

Foshan Treasure Biotechnology Co., Ltd

Tel: 0757-85921206 18520245316
Email: 2329783215@qq.com
Country: China
ProdList: 12661
Advantage: 58

Changzhou Xianglong Pharmaceutical Technology Co., LTD

Tel: 0519-88910898 18661161657
Email: yaoxiangqiu2021@163.com
Country: China
ProdList: 9996
Advantage: 58

Chengdu Push Bio-Technology Co., Ltd.

Tel: 18080489829
Email: 3004654993@qq.com
Country: China
ProdList: 9209
Advantage: 58

Shaanxi DIDU pharmaceutical and Chemical Co., Ltd

Tel: 17691182729 18161915376
Email: 1046@dideu.com
Country: China
ProdList: 10001
Advantage: 58

Shanghai Yanchun Biopharmaceutical Technology Co., Ltd

Tel: 4001-009266 17349750668
Email: product@sci-e.com
Country: China
ProdList: 2808
Advantage: 58

Hubei CuiRan Biotechnology Co., Ltd.

Tel: 18162791556
Email: 3152548389@qq.com
Country: China
ProdList: 4351
Advantage: 58

GIHI CHEMICALS CO.,LIMITED

Tel: +8618058761490
Email: info@gihichemicals.com
Country: China
ProdList: 49978
Advantage: 58

Shaanxi Didu New Materials Co. Ltd

Tel: +86-89586680 +86-13289823923
Email: 1026@dideu.com
Country: China
ProdList: 8670
Advantage: 58

Lanospharma Laboratories Co.,Ltd

Tel: --
Fax: --
Email: sales@lanospharma.com
Country: China
ProdList: 6329
Advantage: 56

480-78-4, platyphyllineRelated Search:

alpha-Terpineol Artemether hydroxygenkwanin beta-Sitosterol Hydroxyecdysone 2-(3,4-Dihydroxyphenyl)-8-(2-O-beta-L-galactopyranosyl-beta-D-glucopyranosyl)-5,7-dihydroxy-4H-1-Benzopyran-4-one beta-Eudesmol MOSLOFLAVONE alpha-Cyperone (4E,6E)-1,7-Diphenyl-4,6-heptadien-3-one NOSCAPINE HYDROCHLORIDE MONOCROTALINE (S)-Pyrrolidin-3-ylmethanol platyphylline ANGELIC ACID ISOAMYL ESTER 1-PROPYL-3-PYRROLIDINEMETHANOL 3-BUTOXYPYRROLIDINE

platyphylline

(1R)-1,2-Dihydro-12-hydroxysenecionan-11,16-dione

[1R,(-)]-1,2-Dihydro-12-hydroxysenecionan-11,16-dione

Platifillin

(1-alpha)-1,2-Dihydro-12-hydroxysenecionan-11,16-dione

66641-38-1 (Hydrochloride)

Einecs 207-558-6

Platiphillin

Platiphyllin

Senecionan-11,16-dione, 1,2-dihydro-12-hydroxy-, (1-alpha)-

12-Hydroxy-1,2-dihydrosenecionan-11,16-dione

Platyphyllin

[1,6]Dioxacyclododecino[2,3,4-gh]pyrrolizine-2,7-dione, 3-ethylidenedodecahydro-6-hydroxy-5,6-dimethyl-, (3Z,5R,6R,9aS,14aR,14bR)-

PLATYPHYLLINI HYDROTARTRAS

480-78-4