ChemicalBook > CAS DataBase List > EFT-508

EFT-508

Product Name
EFT-508
CAS No.
1849590-01-7
Chemical Name
EFT-508
Synonyms
CS-2450;EFT-508;eFT508 -MNK;Tomivosertib;eFT-508 (eFT508);Tomivosertib eFT508;eFT508(Tomivosertib);Tomivosertib, 10 mM in DMSO;EFT 508;EFT-508;TOMIVOSERTIB;6-[(6-aminopyrimidin-4-yl)amino]-8-methylspiro[2H-imidazo[1,5-a]pyridine-3,1'-cyclohexane]-1,5-dione
CBNumber
CB83133222
Molecular Formula
C17H20N6O2
Formula Weight
340.38
MOL File
1849590-01-7.mol
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EFT-508 Property

Melting point:
>300°C
Boiling point:
735.6±60.0 °C(Predicted)
Density 
1.43±0.1 g/cm3(Predicted)
storage temp. 
Refrigerator, under inert atmosphere
solubility 
DMSO (Slightly, Heated), Methanol (Very Slightly)
pka
13.77±0.60(Predicted)
form 
Solid
color 
Pale Yellow
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21957
Product name
eFT508
Purity
≥98%
Packaging
1mg
Price
$68
Updated
2024/03/01
Cayman Chemical
Product number
21957
Product name
eFT508
Purity
≥98%
Packaging
5mg
Price
$302
Updated
2024/03/01
Cayman Chemical
Product number
21957
Product name
eFT508
Purity
≥98%
Packaging
10mg
Price
$535
Updated
2024/03/01
Cayman Chemical
Product number
21957
Product name
eFT508
Purity
≥98%
Packaging
25mg
Price
$1002
Updated
2024/03/01
TRC
Product number
A629153
Product name
6''-[(6-Amino-4-pyrimidinyl)amino]-8''-methylspiro[cyclohexane-1,3''(2''H)-imidazo[1,5-a]pyridine]-1'',5''-dione
Packaging
5mg
Price
$150
Updated
2021/12/16
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EFT-508 Chemical Properties,Usage,Production

Description

eFT508 is a potent inhibitor of MAPK interacting protein kinases (MNK) 1 and 2 (IC50s = <10 nM). It inhibits phosphorylation of eukaryotic initiation factor 4E (eIF4E) with an IC50 value of <50 nM in a cellular signaling assay. eFT508 has a half-life of 5.3 hours in rats.

Uses

6''-[(6-Amino-4-pyrimidinyl)amino]-8''-methylspiro[cyclohexane-1,3''(2''H)-imidazo[1,5-a]pyridine]-1'',5''-dione was used in the study of inhibitors of immune checkpoint modulators and related methods. eFT508 is a potent, highly selective, and orally bioavailable MNK1 and MNK2 inhibitor.

EFT-508 Preparation Products And Raw materials

Raw materials

Preparation Products

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EFT-508 Suppliers

China 78 United States 8 Global 86
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
UHN Shanghai Research & Development Co., Ltd.
Tel
021-58958002 18930822973
Fax
+86 (21) 5895-8628
Email
sales@uhnshanghai.com
Country
China
ProdList
997
Advantage
58
Hangzhou J&H Chemical Co., Ltd.
Tel
0571-+86-571-87396432
Fax
0571-87396431
Email
sales@jhechem.com
Country
China
ProdList
11788
Advantage
59
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4598
Advantage
55
Tongling HengYou Biotechnology Co., Ltd.
Tel
021-50426030 13856289449
Fax
021-50426030
Email
2630597085@qq.com
Country
China
ProdList
1889
Advantage
55
Shanghaizehan biopharma technology co., Ltd.
Tel
021-61350663 13052117465
Fax
021-61350662
Email
sales@zehanbiopharma.com
Country
China
ProdList
999
Advantage
55
Zhengzhou Saifun Biotechnology Co., Ltd.
Tel
022-60688926
Country
China
ProdList
60
Advantage
55
Shanghai Send Pharmaceutical Technology Co., Ltd.
Tel
021-58088081 Q2816483246
Fax
QQ3382968513
Email
danping@shsendpharm.com
Country
China
ProdList
3096
Advantage
55
ATK CHEMICAL COMPANY LIMITED
Tel
021-51619050 13301662590
Fax
+86-21-51619052
Email
mandy@atkchemical.com
Country
China
ProdList
8915
Advantage
55
Shanghai Changyan Chem & Tech Co., Ltd.
Tel
021-20242659 18930833303
Fax
+86 (21) 2024-2659
Email
Sales@changyanchem.cn
Country
China
ProdList
5010
Advantage
55
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View Lastest Price from EFT-508 manufacturers

Career Henan Chemical Co
Product
EFT-508 1849590-01-7
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-08

1849590-01-7, EFT-508Related Search:

2,4,6-Triaminopyrimidine

  • EFT-508
  • 6'-[(6-Amino-4-pyrimidinyl)amino]-8'-methylspiro[cyclohexane-1,3'(2'H)-imidazo[1,5-a]pyridine]-1',5'-dione
  • eFT508 -MNK
  • 6'-((6-aminopyrimidin-4-yl)amino)-8'-methyl-1'H-spiro[cyclohexane-1,3'-imidazo[1,5-a]pyridine]-1',5'(2'H)-dione
  • Tomivosertib
  • eFT-508 (eFT508)
  • Tomivosertib eFT508
  • CS-2450
  • EFT 508;EFT-508;TOMIVOSERTIB
  • 6-[(6-aminopyrimidin-4-yl)amino]-8-methylspiro[2H-imidazo[1,5-a]pyridine-3,1'-cyclohexane]-1,5-dione
  • Spiro[cyclohexane-1,3'(2'H)-imidazo[1,5-a]pyridine]-1',5'-dione, 6'-[(6-amino-4-pyrimidinyl)amino]-8'-methyl-
  • eFT508(Tomivosertib)
  • 6'-[(6-aminopyrimidin-4-yl)amino]-8'-methyl-2',5'-dihydro-1'H-spiro[cyclohexane-1,3'-imidazo[1,5-a]pyridine]-1',5'-dione
  • Tomivosertib, 10 mM in DMSO
  • 1849590-01-7
  • 849590-01-7