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Palmitoyl Tripeptide-8

Product Name
Palmitoyl Tripeptide-8
CAS No.
936544-53-5
Chemical Name
Palmitoyl Tripeptide-8
Synonyms
Neutrazen;Pal-His-D-Phe-Arg-NH2;Palmitoyl Tripeptide-8;Palmiltoyl Tripeptide-8;PALMITOYL TETRAPEPTIDE-8;Palmitoyl Tripeptide-8 TFA salt;Cosmetic Peptide Palmitoyl Tripeptide-8;Factory Supplier Palmitoyl Tripeptide-8;L-Argininamide, N-(1-oxohexadecyl)-L-histidyl-D-phenylalanyl-;Cosmetic Peptide Palmitoyl Tripeptide-8 Neutrazen Powder CAS 936544-53-5 for Anti-Allergic and Repair
CBNumber
CB83135130
Molecular Formula
C37H61N9O4
Formula Weight
695.94
MOL File
936544-53-5.mol
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Palmitoyl Tripeptide-8 Property

Density 
1.20±0.1 g/cm3(Predicted)
pka
13.34±0.46(Predicted)
InChIKey
WBHUVOTYPRYBNG-QAXCHELISA-N
SMILES
C(N)(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](CC1=CC=CC=C1)NC(=O)[C@H](CC1N=CNC=1)NC(=O)CCCCCCCCCCCCCCC
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Hazard and Precautionary Statements (GHS)

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Palmitoyl Tripeptide-8 Chemical Properties,Usage,Production

Description

Palmitoyl tripeptide-8 is a synthetic peptide ester based on a α-melanocyte stimulating hormone (α-MSH), originating from POMC, and it is composed by the sequence N-(1-oxohexadecyl)-L-histidyl-D-phenylalanyl-L-argininamide. Palmitoyl Tripeptide-8 is the product obtained by the reaction of palmitic acid and Tripeptide-8, wherein Tripeptide-8 is a three-residue synthetic peptide consisting of arginine, histidine and phenylalanine[1].

benefits

PalmitoylTripeptide-8 has a high affinity with MC1-R, specific anti-inflammatory activity, inhibit effectively lL-8release induced by UVB, maintain and restore anormal skin sensitivity threshold.Its recommended dosage is 0.3~2.5%.

Synthesis

Palmitoyl Tripeptide-8 can be obtained via a solid-phase peptide synthesis using the fluorenylmethyloxycarbonyl (Fmoc) strategy on an ACT496S2 automated synthesizer with PS-Rink amide (RAM) resin. The deprotection and coupling steps are carried out until the desired sequences are synthesized. Final side-chain deprotection and cleavage from the resin with a cleavage cocktail (trifluoroacetic acid/water/triisopropylsilane) afford palmitoyl tripeptide-8.

in vitro

In in vitro models, palmitoyl tripeptide-8 showed the ability to significantly inhibit IL-8 production up to 32% in UVB-irradiated keratinocytes, which was comparable to α-MSH, and also in IL-1 stimulated fibroblasts, reaching 64% inhibition which is greater that the achieved by α-MSH. In skin explants exposed to substance P, palmitoyl tripeptide-8 significantly reduced the number of dilated capillaries and the size of dilated vessels up to 30% and 51%, respectively. Edema was also reduced by 60% due to palmitoyl tripeptide-8. Palmitoyl tripeptide-8 can prevent and soothe an irritative response.

References

[1] Resende, Diana I S P et al. “Usage of Synthetic Peptides in Cosmetics for Sensitive Skin.” Pharmaceuticals (Basel, Switzerland) vol. 14,8 702. 21 Jul. 2021, doi:10.3390/ph14080702

Palmitoyl Tripeptide-8 Preparation Products And Raw materials

Raw materials

Preparation Products

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Palmitoyl Tripeptide-8 Suppliers

Chengdu Youngshe Chemical Co., Ltd.
Tel
+86-17380623303 +86-17380623303
Fax
028-62328193
Email
Caroline@youngshechem.com
Country
China
ProdList
4810
Advantage
58
Spec-Chem Industry Inc.
Tel
025-84523390 13505162978
Email
sc@specchemind.com
Country
China
ProdList
117
Advantage
58
Shandong Jitai Biotech Co., Ltd
Tel
18366132549
Email
372278065@qq.com
Country
China
ProdList
30
Advantage
58
Chinapeptide
Tel
15295566865 15295566865
Email
glenn@synpeptide.com
Country
China
ProdList
31
Advantage
58
bociny
Tel
18939812306
Email
sales@bociny.com
Country
China
ProdList
96
Advantage
58
Chengdu Shengnuo Biological Peptide Technology Co.,Ltd
Tel
028-88368562
Email
liweidan@snbiopharm.com
Country
China
ProdList
27
Advantage
58
GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Fax
86-21-61263399
Email
ymbetter@glbiochem.com
Country
China
ProdList
9981
Advantage
64
Cellmano Biotech Limited
Tel
0551-65326643 18156095617
Fax
0551-65326641
Email
info@cellmano.com
Country
China
ProdList
1011
Advantage
55
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3239
Advantage
55
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
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View Lastest Price from Palmitoyl Tripeptide-8 manufacturers

Shanghai UCHEM Inc.
Product
Palmitoyl Tripeptide-8 936544-53-5
Price
US $30.00/mg
Min. Order
15mg
Purity
0.98
Supply Ability
1kg
Release date
2024-04-18
Hebei Zhuanglai Chemical Trading Co Ltd
Product
Palmitoyl Tripeptide-8 936544-53-5
Price
US $45.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 tons
Release date
2024-11-14
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Palmitoyl Tripeptide-8 936544-53-5
Price
US $0.00/g
Min. Order
1g
Purity
95%
Supply Ability
1000g
Release date
2021-12-17

936544-53-5, Palmitoyl Tripeptide-8Related Search:


  • Neutrazen
  • Palmitoyl Tripeptide-8
  • Palmiltoyl Tripeptide-8
  • L-Argininamide, N-(1-oxohexadecyl)-L-histidyl-D-phenylalanyl-
  • Factory Supplier Palmitoyl Tripeptide-8
  • Cosmetic Peptide Palmitoyl Tripeptide-8 Neutrazen Powder CAS 936544-53-5 for Anti-Allergic and Repair
  • Pal-His-D-Phe-Arg-NH2
  • PALMITOYL TETRAPEPTIDE-8
  • Cosmetic Peptide Palmitoyl Tripeptide-8
  • Palmitoyl Tripeptide-8 TFA salt
  • 936544-53-5
  • C37H61N9O4