Palmitoyl Tripeptide-8
- Product Name
- Palmitoyl Tripeptide-8
- CAS No.
- 936544-53-5
- Chemical Name
- Palmitoyl Tripeptide-8
- Synonyms
- Neutrazen;Pal-His-D-Phe-Arg-NH2;Palmitoyl Tripeptide-8;Palmiltoyl Tripeptide-8;PALMITOYL TETRAPEPTIDE-8;Palmitoyl Tripeptide-8 TFA salt;Cosmetic Peptide Palmitoyl Tripeptide-8;Factory Supplier Palmitoyl Tripeptide-8;L-Argininamide, N-(1-oxohexadecyl)-L-histidyl-D-phenylalanyl-;Cosmetic Peptide Palmitoyl Tripeptide-8 Neutrazen Powder CAS 936544-53-5 for Anti-Allergic and Repair
- CBNumber
- CB83135130
- Molecular Formula
- C37H61N9O4
- Formula Weight
- 695.94
- MOL File
- 936544-53-5.mol
Palmitoyl Tripeptide-8 Property
- Density
- 1.20±0.1 g/cm3(Predicted)
- pka
- 13.34±0.46(Predicted)
- InChIKey
- WBHUVOTYPRYBNG-QAXCHELISA-N
- SMILES
- C(N)(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](CC1=CC=CC=C1)NC(=O)[C@H](CC1N=CNC=1)NC(=O)CCCCCCCCCCCCCCC
Palmitoyl Tripeptide-8 Chemical Properties,Usage,Production
Description
Palmitoyl tripeptide-8 is a synthetic peptide ester based on a α-melanocyte stimulating hormone (α-MSH), originating from POMC, and it is composed by the sequence N-(1-oxohexadecyl)-L-histidyl-D-phenylalanyl-L-argininamide. Palmitoyl Tripeptide-8 is the product obtained by the reaction of palmitic acid and Tripeptide-8, wherein Tripeptide-8 is a three-residue synthetic peptide consisting of arginine, histidine and phenylalanine[1].
benefits
PalmitoylTripeptide-8 has a high affinity with MC1-R, specific anti-inflammatory activity, inhibit effectively lL-8release induced by UVB, maintain and restore anormal skin sensitivity threshold.Its recommended dosage is 0.3~2.5%.
Synthesis
Palmitoyl Tripeptide-8 can be obtained via a solid-phase peptide synthesis using the fluorenylmethyloxycarbonyl (Fmoc) strategy on an ACT496S2 automated synthesizer with PS-Rink amide (RAM) resin. The deprotection and coupling steps are carried out until the desired sequences are synthesized. Final side-chain deprotection and cleavage from the resin with a cleavage cocktail (trifluoroacetic acid/water/triisopropylsilane) afford palmitoyl tripeptide-8.
in vitro
In in vitro models, palmitoyl tripeptide-8 showed the ability to significantly inhibit IL-8 production up to 32% in UVB-irradiated keratinocytes, which was comparable to α-MSH, and also in IL-1 stimulated fibroblasts, reaching 64% inhibition which is greater that the achieved by α-MSH. In skin explants exposed to substance P, palmitoyl tripeptide-8 significantly reduced the number of dilated capillaries and the size of dilated vessels up to 30% and 51%, respectively. Edema was also reduced by 60% due to palmitoyl tripeptide-8. Palmitoyl tripeptide-8 can prevent and soothe an irritative response.
References
[1] Resende, Diana I S P et al. “Usage of Synthetic Peptides in Cosmetics for Sensitive Skin.” Pharmaceuticals (Basel, Switzerland) vol. 14,8 702. 21 Jul. 2021, doi:10.3390/ph14080702
Palmitoyl Tripeptide-8 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Palmitoyl Tripeptide-8 manufacturers
- Product
- Palmitoyl Tripeptide-8 936544-53-5
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 50kg
- Release date
- 2025-02-11
- Product
- Palmitoyl Tripeptide-8 936544-53-5
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2024-09-27
- Product
- Palmitoyl Tripeptide-8 936544-53-5
- Price
- US $45.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2024-11-14