1-((S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl)-3-((S)-1-(thiophen-3-yl)propan-2-yl)urea

Product Name: 1-((S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl)-3-((S)-1-(thiophen-3-yl)propan-2-yl)urea
CAS No.: 1997387-43-5
Chemical Name: 1-((S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl)-3-((S)-1-(thiophen-3-yl)propan-2-yl)urea
Synonyms: PZM-21;PZM 21; PZM-21;PZM21, 10 mM in DMSO;Opioid Receptor,Inhibitor,PZM21,inhibit,PZM 21,PZM-21;1-((S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl)-3-((S)-1-(thiophen-3-yl)propan-2-yl)urea;1-[(2S)-2-(Dimethylamino)-3-(4-hydroxyphenyl)propyl]-3-[(2S)-1-(thiophen-3-yl)propan-2-yl]urea;Urea, N-[(2S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl]-N'-[(1S)-1-methyl-2-(3-thienyl)ethyl]-
CBNumber: CB83137417
Molecular Formula: C19H27N3O2S
Formula Weight: 361.5
MOL File: 1997387-43-5.mol

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1-((S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl)-3-((S)-1-(thiophen-3-yl)propan-2-yl)urea Property

Boiling point:: 583.8±50.0 °C(Predicted)
Density: 1.169±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:100.0(Max Conc. mg/mL);276.63(Max Conc. mM)
Ethanol:10.0(Max Conc. mg/mL);27.7(Max Conc. mM)
form: A crystalline solid
pka: 10.06±0.15(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 20576
Product name: PZM21
Packaging: 1mg
Price: $33
Updated: 2024/03/01

Cayman Chemical

Product number: 20576
Product name: PZM21
Packaging: 25mg
Price: $245
Updated: 2024/03/01

Cayman Chemical

Product number: 20576
Product name: PZM21
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 20576
Product name: PZM21
Packaging: 10mg
Price: $164
Updated: 2024/03/01

Tocris

Product number: 7218
Product name: PZM21
Purity: ≥98%(HPLC)
Packaging: 10
Price: $199
Updated: 2021/12/16

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1-((S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl)-3-((S)-1-(thiophen-3-yl)propan-2-yl)urea Chemical Properties,Usage,Production

Uses

PZM21 is a potent Gi activator with exceptional selectivity for μOR and minimal β-arrestin-2 recruitment. PZM21 is an experimental opioid analgesic drug that is being researched for the treatment of pain. It is a functionally selective μ-opioid receptor agonist which produces μ-opioid receptor mediated G protein signaling, with potency and efficacy similar to morphine, but with less β-arrestin 2 recruitment. In tests on mice, PZM21 was slightly less potent than morphine or TRV130 as an analgesic, but also had significantly reduced adverse effects, with less constipation than morphine, and very little respiratory depression, even at high doses.

in vivo

PZM21 is a potent Gi activator with exceptional selectivity for μOR and minimal β-arrestin-2 recruitment. PZM21 is efficacious for the affective component of analgesia versus the reflexive component and is devoid of respiratory depression in mice at equi-analgesic doses. PZM21 displays dose-dependent analgesia in a mouse hotplate assay, with a per cent maximal possible effect (% MPE) of 87% reached 15 min after administration of the highest dose of drug tested ^[1].PZM21 has a long-lasting analgesic effect on CNS mediated-pain responses, but does not cause respiratory depression and constipation, two key side effects of opioid agonists^[2].

IC 50

μ Opioid Receptor/MOR

storage

Store at -20°C

1-((S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl)-3-((S)-1-(thiophen-3-yl)propan-2-yl)urea Preparation Products And Raw materials

Raw materials

Preparation Products

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1-((S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl)-3-((S)-1-(thiophen-3-yl)propan-2-yl)urea Suppliers

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1997387-43-5, 1-((S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl)-3-((S)-1-(thiophen-3-yl)propan-2-yl)ureaRelated Search:

1-((S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl)-3-((S)-1-(thiophen-3-yl)propan-2-yl)urea

PZM-21

PZM 21; PZM-21

1-[(2S)-2-(Dimethylamino)-3-(4-hydroxyphenyl)propyl]-3-[(2S)-1-(thiophen-3-yl)propan-2-yl]urea

Urea, N-[(2S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl]-N'-[(1S)-1-methyl-2-(3-thienyl)ethyl]-

Opioid Receptor,Inhibitor,PZM21,inhibit,PZM 21,PZM-21

PZM21, 10 mM in DMSO

1997387-43-5