ChemicalBook > CAS DataBase List > iMDK
iMDK
- Product Name
- iMDK
- CAS No.
- 881970-80-5
- Chemical Name
- iMDK
- Synonyms
- iMDK;iMDK, 10 mM in DMSO;3-[2-(4-Fluoro-benzyl)-imidazo[2,1-b]thiazol-6-yl]-chromen-2-one;3-(2-(4-Fluorobenzyl)imidazo[2,1-b]thiazol-6-yl)-2H-chromen-2-one;3-[2-[(4-Fluorophenyl)methyl]imidazo[2,1-b]thiazol-6-yl]-2H-1-benzopyran-2-one;2H-1-Benzopyran-2-one, 3-[2-[(4-fluorophenyl)methyl]imidazo[2,1-b]thiazol-6-yl]-;inhibit,iMDK,midkine,factor,PI3K,NSCLC,growth,Inhibitor,Phosphoinositide 3-kinase,MDK
- CBNumber
- CB83146307
- Molecular Formula
- C21H13FN2O2S
- Formula Weight
- 376.4
- MOL File
- 881970-80-5.mol
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iMDK Property
- Density
- 1.42±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C, protect from light
- solubility
- Limited solubility
- pka
- 5.71±0.40(Predicted)
- form
- Solid
- color
- Off-white to yellow
- InChI
- InChI=1S/C21H13FN2O2S/c22-15-7-5-13(6-8-15)9-16-11-24-12-18(23-21(24)27-16)17-10-14-3-1-2-4-19(14)26-20(17)25/h1-8,10-12H,9H2
- InChIKey
- IWFKQTWYILKFGE-UHFFFAOYSA-N
- SMILES
- C1(=O)OC2=CC=CC=C2C=C1C1=CN2C=C(CC3=CC=C(F)C=C3)SC2=N1
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N-Bromosuccinimide Price
TRC
- Product number
- M320748
- Product name
- iMDK
- Packaging
- 2.5mg
- Price
- $195
- Updated
- 2021/12/16
TRC
- Product number
- M320748
- Product name
- iMDK
- Packaging
- 5mg
- Price
- $345
- Updated
- 2021/12/16
Usbiological
- Product number
- 255499
- Product name
- iMDK
- Packaging
- 10mg
- Price
- $466
- Updated
- 2021/12/16
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iMDK Chemical Properties,Usage,Production
Uses
iMDK is a small molecule inhibitor used to bind to midkine (MDK), a heparin binding growth factor that is expressed in malignant tumors.
Biological Activity
Cell permeable: yes', 'Primary Target
Midkine', 'Reversible: yes
in vivo
The combination treatment of iMDK ( (9 mg/kg/day; intraperitoneally injected with 100 μl) and PD0325901 (5 mg/kg; orally administered) effectively reduced lung tumor growth in a xenograft mouse model[1].
| Animal Model: | female BALB/c nude mice (6 week old) bearing H441 human lung cancer xenografts[1] |
| Dosage: | iMDK (9 mg/kg) and PD0325901 (5 mg/kg) |
| Administration: | Intraperitoneally injected with 100 μL iMDK everyday and/or orally administered PD0325901 five times per week (on days 1, 2, 3, 4, 5, 7, 8, 9, 10, 11) |
| Result: | Reduced significantly volume of the tumors derived from H441 lung adenocarcinoma cells after the combination treatment with iMDK and PD0325901 compared to that of single compound in a xenograft mouse model. |
storage
Store at +4°C
iMDK Preparation Products And Raw materials
Raw materials
Preparation Products
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iMDK Suppliers
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