ChemicalBook > CAS DataBase List > CZ415

CZ415

Product Name
CZ415
CAS No.
1429639-50-8
Chemical Name
CZ415
Synonyms
CZ415;CS-2392;CZ 415;CZ-415;CZ415 (Free base);CZ415, 10 mM in DMSO;inhibit,Inhibitor,mTOR,CZ415,CZ-415,CZ 415,Mammalian target of Rapamycin;(S)-1-(4-(7,7-dimethyl-4-(3-methylmorpholino)-6,6-dioxido-5,7-dihydrothieno[3,4-d]pyrimidin-2-yl)phenyl)-3-ethylurea;Urea, N-[4-[5,7-dihydro-7,7-dimethyl-4-[(3S)-3-methyl-4-morpholinyl]-6,6-dioxidothieno[3,4-d]pyrimidin-2-yl]phenyl]-N'-ethyl-
CBNumber
CB83146695
Molecular Formula
C22H29N5O4S
Formula Weight
459.56
MOL File
1429639-50-8.mol
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CZ415 Property

Boiling point:
611.4±55.0 °C(Predicted)
Density 
1.287±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:73.67(Max Conc. mg/mL);160.3(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:6):0.1(Max Conc. mg/mL);0.22(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);65.28(Max Conc. mM)
Ethanol:10.0(Max Conc. mg/mL);21.76(Max Conc. mM)
form 
A crystalline solid
pka
13.79±0.46(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
27668
Product name
CZ415
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
27668
Product name
CZ415
Packaging
25mg
Price
$586
Updated
2024/03/01
Cayman Chemical
Product number
27668
Product name
CZ415
Packaging
5mg
Price
$172
Updated
2024/03/01
Cayman Chemical
Product number
27668
Product name
CZ415
Packaging
10mg
Price
$321
Updated
2024/03/01
TRC
Product number
C998985
Product name
CZ415
Packaging
2.5mg
Price
$210
Updated
2021/12/16
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CZ415 Chemical Properties,Usage,Production

Description

CZ415 is an inhibitor of mammalian target of rapamycin (mTOR; Kd = 6.3 nM). It is 1,000-fold selective for mTOR over a panel of 285 kinases. CZ415 inhibits phosphorylation of S6 ribosomal protein (S6RP) and Akt in HEK293T cells (IC50s = 14.5 and 14.8 nM, respectively). It inhibits IFN-γ secretion in IL-2, anti-CD3, and anti-CD28 antibody-stimulated human whole blood (IC50 = 226 nM). CZ415 (10 mg/kg) reduces fore paw joint erythema and swelling in a mouse model of collagen-induced arthritis. It also inhibits intratumor mTOR activity and reduces tumor growth in an OCC-1 oral cavity carcinoma mouse xenograft model when administered at a dose of 20 mg/kg.

Uses

CZ415 is a selective and potent ATP-competitive mTOR inhibitor (1). It demonstrated in vivo efficacy in a semitherapeutic collagen induced arthritis (CIA) mouse model.

CZ415 Preparation Products And Raw materials

Raw materials

Preparation Products

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CZ415 Suppliers

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1429639-50-8, CZ415Related Search:


  • (S)-1-(4-(7,7-dimethyl-4-(3-methylmorpholino)-6,6-dioxido-5,7-dihydrothieno[3,4-d]pyrimidin-2-yl)phenyl)-3-ethylurea
  • CS-2392
  • CZ415
  • CZ415 (Free base)
  • CZ 415;CZ-415
  • Urea, N-[4-[5,7-dihydro-7,7-dimethyl-4-[(3S)-3-methyl-4-morpholinyl]-6,6-dioxidothieno[3,4-d]pyrimidin-2-yl]phenyl]-N'-ethyl-
  • inhibit,Inhibitor,mTOR,CZ415,CZ-415,CZ 415,Mammalian target of Rapamycin
  • CZ415, 10 mM in DMSO
  • 1429639-50-8