CZ415
- Product Name
- CZ415
- CAS No.
- 1429639-50-8
- Chemical Name
- CZ415
- Synonyms
- CZ415;CS-2392;CZ 415;CZ-415;CZ415 (Free base);inhibit,Inhibitor,mTOR,CZ415,CZ-415,CZ 415,Mammalian target of Rapamycin;(S)-1-(4-(7,7-dimethyl-4-(3-methylmorpholino)-6,6-dioxido-5,7-dihydrothieno[3,4-d]pyrimidin-2-yl)phenyl)-3-ethylurea;Urea, N-[4-[5,7-dihydro-7,7-dimethyl-4-[(3S)-3-methyl-4-morpholinyl]-6,6-dioxidothieno[3,4-d]pyrimidin-2-yl]phenyl]-N'-ethyl-
- CBNumber
- CB83146695
- Molecular Formula
- C22H29N5O4S
- Formula Weight
- 459.56
- MOL File
- 1429639-50-8.mol
CZ415 Property
- Boiling point:
- 611.4±55.0 °C(Predicted)
- Density
- 1.287±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:73.67(Max Conc. mg/mL);160.3(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:6):0.1(Max Conc. mg/mL);0.22(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);65.28(Max Conc. mM)
Ethanol:10.0(Max Conc. mg/mL);21.76(Max Conc. mM) - form
- A crystalline solid
- pka
- 13.79±0.46(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- 27668
- Product name
- CZ415
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 27668
- Product name
- CZ415
- Packaging
- 25mg
- Price
- $586
- Updated
- 2024/03/01
- Product number
- 27668
- Product name
- CZ415
- Packaging
- 5mg
- Price
- $172
- Updated
- 2024/03/01
- Product number
- 27668
- Product name
- CZ415
- Packaging
- 10mg
- Price
- $321
- Updated
- 2024/03/01
- Product number
- C998985
- Product name
- CZ415
- Packaging
- 2.5mg
- Price
- $210
- Updated
- 2021/12/16
CZ415 Chemical Properties,Usage,Production
Description
CZ415 is an inhibitor of mammalian target of rapamycin (mTOR; Kd = 6.3 nM). It is 1,000-fold selective for mTOR over a panel of 285 kinases. CZ415 inhibits phosphorylation of S6 ribosomal protein (S6RP) and Akt in HEK293T cells (IC50s = 14.5 and 14.8 nM, respectively). It inhibits IFN-γ secretion in IL-2, anti-CD3, and anti-CD28 antibody-stimulated human whole blood (IC50 = 226 nM). CZ415 (10 mg/kg) reduces fore paw joint erythema and swelling in a mouse model of collagen-induced arthritis. It also inhibits intratumor mTOR activity and reduces tumor growth in an OCC-1 oral cavity carcinoma mouse xenograft model when administered at a dose of 20 mg/kg.
Uses
CZ415 is a selective and potent ATP-competitive mTOR inhibitor (1). It demonstrated in vivo efficacy in a semitherapeutic collagen induced arthritis (CIA) mouse model.