Centanafadine HCl
- Product Name
- Centanafadine HCl
- CAS No.
- 923981-14-0
- Chemical Name
- Centanafadine HCl
- Synonyms
- CTN SR;EB-1020 SR;Centanafadine HCl;EB-1020 hydrochloride;Centafadine hydrochloride;Centanafadine hydrochloride, 10 mM in DMSO;Centanafadine hydrochloride (EB-1020 (hydrochloride));Centanafadine hydrochloride (Synonyms: EB-1020 (hydrochloride));(1R,5S)-(+)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane hydrochloride;Centanafadine,SLC6A3,5-HTT,EB 1020,Centanafadine hydrochloride,Dopamine Transporter,SLC6A4,Beta Receptor,DAT,EB-1020,inhibit,SERT,Serotonin Transporter,EB1020,Adrenergic Receptor,Inhibitor
- CBNumber
- CB83151653
- Molecular Formula
- C15H16ClN
- Formula Weight
- 245.75
- MOL File
- 923981-14-0.mol
Centanafadine HCl Property
- storage temp.
- Store at -20°C
- solubility
- DMSO: 125 mg/mL (508.65 mM)
- form
- Solid
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H228Flammable solid
H252Self-heating in large quantities; may catch fire
H360May damage fertility or the unborn child
H400Very toxic to aquatic life
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P235+P410Keep cool. Protect from sunlight.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P370+P378In case of fire: Use … for extinction.
P391Collect spillage. Hazardous to the aquatic environment
P407Maintain air gap between stacks/pallets.
P413Store bulk masses greater than … kg/…lbs at temperatures not exceeding … oC/…oF.
P420Store away from other materials.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C256620
- Product name
- CentanafadineHydrochloride
- Packaging
- 100mg
- Price
- $1320
- Updated
- 2021/12/16
- Product number
- CS-0077776
- Product name
- Centanafadinehydrochloride
- Purity
- 99.93%
- Packaging
- 5mg
- Price
- $205
- Updated
- 2021/12/16
- Product number
- CS-0077776
- Product name
- Centanafadinehydrochloride
- Purity
- 99.93%
- Packaging
- 10mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- CS-0077776
- Product name
- Centanafadinehydrochloride
- Purity
- 99.93%
- Packaging
- 50mg
- Price
- $1200
- Updated
- 2021/12/16
- Product number
- CS-0077776
- Product name
- Centanafadinehydrochloride
- Purity
- 99.93%
- Packaging
- 100mg
- Price
- $2100
- Updated
- 2021/12/16
Centanafadine HCl Chemical Properties,Usage,Production
Uses
Centanafadine Hydrochloride is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI) used as a treatment for attention deficit hyperactivity disorder (ADHD) that is in phase II clinical trials.
in vivo
In microdialysis studies, Centanafadine markedly increases NE, and DA concentrations levels in rat prefrontal cortex in vivo with peak increases of 375 and 300%, respectively with the greatest effects on NE, and also increases DA extracellular concentrations in the striatum to 400% of baseline concentrations. Behavioral studies demonstrate that Centanafadine dose-dependently decreases immobility in the mouse tail suspension test of depression to 13% of control levels, and do not stimulate locomotor activity in adult rats in the optimal dose range. Centanafadine dose-dependently inhibits locomotor hyperactivity in juvenile rats lesioned with the neurotoxin 6-hydroxydopamine (100 μg intracisternally) as neonates; a well-established animal model for attention-deficit hyperactivity disorder (ADHD)[1].
Centanafadine HCl Preparation Products And Raw materials
Raw materials
Preparation Products
Centanafadine HCl Suppliers
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