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SF2523

Product Name
SF2523
CAS No.
1174428-47-7
Chemical Name
SF2523
Synonyms
SF2523;SF-2523;CS-2518;SF-2523; SF 2523;SF2523, 10 mM in DMSO;3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-morpholino-7H-thieno[3,2-b]pyran-7-one;7H-Thieno[3,2-b]pyran-7-one, 3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-(4-morpholinyl)-;SF 2523,Inhibitor,PI3K,SF-2523,Phosphoinositide 3-kinase,Epigenetic Reader Domain,DNA-dependent protein kinase,DNA-PK,inhibit,SF2523
CBNumber
CB83158526
Molecular Formula
C19H17NO5S
Formula Weight
371.41
MOL File
1174428-47-7.mol
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SF2523 Property

Boiling point:
538.0±50.0 °C(Predicted)
Density 
1.423±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF:10.0(Max Conc. mg/mL);26.92(Max Conc. mM)
DMSO:29.5(Max Conc. mg/mL);79.43(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:9):0.1(Max Conc. mg/mL);0.27(Max Conc. mM)
Ethanol:7.0(Max Conc. mg/mL);18.85(Max Conc. mM)
form 
A crystalline solid
pka
0.55±0.20(Predicted)
color 
Light yellow to khaki
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21638
Product name
SF2523
Purity
≥98%
Packaging
500μg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
21638
Product name
SF2523
Purity
≥98%
Packaging
1mg
Price
$106
Updated
2024/03/01
Cayman Chemical
Product number
21638
Product name
SF2523
Purity
≥98%
Packaging
5mg
Price
$388
Updated
2024/03/01
Cayman Chemical
Product number
21638
Product name
SF2523
Purity
≥98%
Packaging
10mg
Price
$723
Updated
2024/03/01
TRC
Product number
S080725
Product name
SF2523
Packaging
5mg
Price
$165
Updated
2021/12/16
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SF2523 Chemical Properties,Usage,Production

Uses

SF2523 is a dual action inhibitor that blocks tumor growth and metastasis and for the development of anticancer therapy.

in vivo

SF2523 treatment results in a significant reduction of tumor volume compared with control. Importantly, SF2523 shows no gross toxicity to the treated mice, as there is no notable change in body weight. Tumors from SF2523-treated mice have markedly reduced MYCN, pAKT, and Cyclin D1 levels compared with levels of these proteins in vehicle-treated mice tumors[2].

IC 50

PI3Kα: 34 nM (IC50); PI3Kγ: 158 nM (IC50); BRD4 (BD1): 241 nM (IC50); DNA-PK: 9 nM (IC50); mTOR: 280 nM (IC50)

SF2523 Preparation Products And Raw materials

Raw materials

Preparation Products

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SF2523 Suppliers

China 71 United States 6 Global 77
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81

1174428-47-7, SF2523Related Search:


  • SF2523
  • SF-2523
  • 3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-morpholino-7H-thieno[3,2-b]pyran-7-one
  • SF-2523; SF 2523
  • CS-2518
  • 7H-Thieno[3,2-b]pyran-7-one, 3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-(4-morpholinyl)-
  • SF 2523,Inhibitor,PI3K,SF-2523,Phosphoinositide 3-kinase,Epigenetic Reader Domain,DNA-dependent protein kinase,DNA-PK,inhibit,SF2523
  • SF2523, 10 mM in DMSO
  • 1174428-47-7