ChemicalBook > CAS DataBase List > 3-(4-Phenoxyphenyl)-1-(4-piperidinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
3-(4-Phenoxyphenyl)-1-(4-piperidinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
- Product Name
- 3-(4-Phenoxyphenyl)-1-(4-piperidinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
- CAS No.
- 330785-90-5
- Chemical Name
- 3-(4-Phenoxyphenyl)-1-(4-piperidinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
- Synonyms
- BTK ligand 1;Ibrutinib Impurity 45;N-piperidine Ibrutinib;Ibrutinib Impurity ZY3;N piperidine Ibrutinib,Npiperidine Ibrutinib;3-(4-Phenoxyphenyl)-1-(4-piperidinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine;1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 3-(4-phenoxyphenyl)-1-(4-piperidinyl)-
- CBNumber
- CB83158748
- Molecular Formula
- C22H22N6O
- Formula Weight
- 386.45
- MOL File
- 330785-90-5.mol
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3-(4-Phenoxyphenyl)-1-(4-piperidinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Property
- Boiling point:
- 626.3±55.0 °C(Predicted)
- Density
- 1.39±0.1 g/cm3(Predicted)
- pka
- 9.63±0.10(Predicted)
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3-(4-Phenoxyphenyl)-1-(4-piperidinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Chemical Properties,Usage,Production
Uses
BTK ligand 1 (compound 1) is a ligand targeting Bruton’s tyrosine kinase (Btk). BTK ligand 1 can combine with E3 ligase ligand (Ligand for E3 Ligase) through PROTAC Linker to form PROTAC. PROTACs targeting Btk can be used in the study of chronic lymphocytic leukemia (CLL) and other BK cell malignancies[1].
References
[1] Buhimschi AD, et al. Targeting the C481S Ibrutinib-Resistance Mutation in Bruton's Tyrosine Kinase Using PROTAC-Mediated Degradation. Biochemistry. 2018 Jul 3;57(26):3564-3575. DOI:10.1021/acs.biochem.8b00391
3-(4-Phenoxyphenyl)-1-(4-piperidinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Preparation Products And Raw materials
Raw materials
Preparation Products
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330785-90-5, 3-(4-Phenoxyphenyl)-1-(4-piperidinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineRelated Search:
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