2-Amino-4-nitrophenol Property

Melting point:

140-143 °C (lit.)

Boiling point:

322.46°C (rough estimate)

Density 

1.3617 (estimate)

vapor pressure 

0.005Pa at 25℃

refractive index 

1.6890 (rough estimate)

Flash point:

100 °C

storage temp. 

Refrigerator, Under Inert Atmosphere

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

6.82±0.22(Predicted)

color 

Dark Yellow to Brown

Water Solubility 

slightly soluble

BRN 

776533

LogP

1.26

CAS DataBase Reference

99-57-0(CAS DataBase Reference)

IARC

3 (Vol. 57) 1993

EPA Substance Registry System

2-Amino-4-nitrophenol (99-57-0)

Safety

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-68-43-40-20/21/22

Safety Statements 

26-45-36/37/39-36

RIDADR 

2811

WGK Germany 

2

RTECS 

SJ6300000

Hazard Note 

Irritant

TSCA 

Yes

HS Code 

29071990

Hazardous Substances Data

99-57-0(Hazardous Substances Data)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

2-Amino-4-nitrophenol Chemical Properties,Usage,Production

Chemical Properties

OCHRE CRYSTALLINE POWDER

Uses

An aromatic constituent found in hair dyes and other cosmetic products with very low levels of mutagenic activity.

Uses

2-Amino-4-nitrophenol is used in preparing some mordant dyes and in some hair dyes.

Definition

ChEBI: 2-Amino-4-nitrophenol is a member of 4-nitrophenols.

Synthesis Reference(s)

Organic Syntheses, Coll. Vol. 3, p. 82, 1955
The Journal of Organic Chemistry, 45, p. 4992, 1980 DOI: 10.1021/jo01312a039

General Description

Orange prisms or yellow powder. No odor.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Oxidation of 2-Amino-4-nitrophenol may occur in the presence of air and violent decomposition may occur if 2-Amino-4-nitrophenol is allowed to dry out completely at elevated temperatures. 2-Amino-4-nitrophenol is stable when stored protected from light and under nitrogen for two weeks at temperatures up to 140° F, and storage under nitrogen for up to 24 weeks at room temperature (77° F) should produce no loss of stability. 2-Amino-4-nitrophenol is incompatible with acids, acid chlorides, acid anhydrides, chloroformates and strong oxidizing agents. 2-Amino-4-nitrophenol is also incompatible with iron.

Fire Hazard

Flash point data for 2-Amino-4-nitrophenol are not available. 2-Amino-4-nitrophenol is probably combustible.

Flammability and Explosibility

Non flammable

Purification Methods

Crystallise the phenol from water. [Beilstein 13 IV 896.]