ChemicalBook > CAS DataBase List > Seletalisib

Seletalisib

Product Name
Seletalisib
CAS No.
1362850-20-1
Chemical Name
Seletalisib
Synonyms
UCB5857;Seletalisib;UCB-5857;UCB5857;Seletalisib(UCB-5857);Seletalisib, 10 mM in DMSO;UCB5857; UCB-5857; UCB 5857;Seletalisib (UCB-5857) ，S8560;Inhibitor,Phosphoinositide 3-kinase,Seletalisib,UCB-5857,UCB 5857,inhibit,PI3K;(R)-3-(8-Chloro-3-(2,2,2-trifluoro-1-(pyrido[3,2-d]pyrimidin-4-ylamino)ethyl)quinolin-2-yl)pyridine 1-oxide;Pyrido[3,2-d]pyrimidin-4-amine, N-[(1R)-1-[8-chloro-2-(1-oxido-3-pyridinyl)-3-quinolinyl]-2,2,2-trifluoroethyl]-
CBNumber
CB83171699
Molecular Formula
C23H14ClF3N6O
Formula Weight
482.85
MOL File
1362850-20-1.mol
More
Less

Seletalisib Property

Boiling point:
710.8±60.0 °C(Predicted)
Density 
1.53±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : ≥ 83.3 mg/mL (172.52 mM)
form 
Solid
pka
3.55±0.30(Predicted)
color 
White to off-white
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

ChemScene
Product number
CS-6470
Product name
Seletalisib
Purity
98.50%
Packaging
1mg
Price
$90
Updated
2021/12/16
ChemScene
Product number
CS-6470
Product name
Seletalisib
Purity
98.50%
Packaging
5mg
Price
$260
Updated
2021/12/16
ChemScene
Product number
CS-6470
Product name
Seletalisib
Purity
98.50%
Packaging
10mg
Price
$420
Updated
2021/12/16
ChemScene
Product number
CS-6470
Product name
Seletalisib
Purity
98.50%
Packaging
50mg
Price
$1250
Updated
2021/12/16
ChemScene
Product number
CS-6470
Product name
Seletalisib
Purity
98.50%
Packaging
100mg
Price
$2100
Updated
2021/12/16
More
Less

Seletalisib Chemical Properties,Usage,Production

Uses

Seletalisib (UCB5857) is potent and selective PI3Kδ inhibitor with an IC50 of 12 nM.

in vivo

Seletalisib significantly inhibits IL-2 release following TCR stimulation in the rat. The inhibition is observed at all tested doses of seletalisib with almost complete inhibition reached at dose levels ≥1 mg/kg. Seletalisib has potent in vivo effects with an estimated IC50 value of <10 nM[1].

IC 50

PI3Kδ: 12 nM (IC50)

References

[1] Allen RA, et al. Seletalisib: Characterization of a Novel, Potent, and Selective Inhibitor of PI3Kδ. J Pharmacol Exp Ther. 2017 Apr 25. pii: jpet.116.237347. DOI:10.1124/jpet.116.237347

Seletalisib Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Seletalisib Suppliers

China 43 United States 6 Global 49
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
Shanghai Jian Chao Chemical Technology Co., Ltd.
Tel
150-2103-5486 18017383231
Fax
qq：2817624287
Email
983544897@qq.com
Country
China
ProdList
9342
Advantage
55
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3506
Advantage
58
DKMbiochem.Co. Ltd
Tel
15901859516
Fax
15901859516
Email
sales@DKMbiochem.com
Country
China
ProdList
344
Advantage
58
Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Fax
028-81705658
Email
3003855609@qq.com
Country
China
ProdList
7778
Advantage
56
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4757
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
Shanghai Rechem science Co., Ltd.
Tel
021-31433387 15618786686
Fax
QQ:1369748377
Email
sales@rechemscience.com
Country
China
ProdList
2990
Advantage
58

1362850-20-1, SeletalisibRelated Search:


  • Seletalisib
  • UCB5857
  • Seletalisib(UCB-5857)
  • UCB5857; UCB-5857; UCB 5857
  • UCB-5857;UCB5857
  • Pyrido[3,2-d]pyrimidin-4-amine, N-[(1R)-1-[8-chloro-2-(1-oxido-3-pyridinyl)-3-quinolinyl]-2,2,2-trifluoroethyl]-
  • Inhibitor,Phosphoinositide 3-kinase,Seletalisib,UCB-5857,UCB 5857,inhibit,PI3K
  • (R)-3-(8-Chloro-3-(2,2,2-trifluoro-1-(pyrido[3,2-d]pyrimidin-4-ylamino)ethyl)quinolin-2-yl)pyridine 1-oxide
  • Seletalisib, 10 mM in DMSO
  • Seletalisib (UCB-5857) ，S8560
  • 1362850-20-1
  • C23H14ClF3N6O