(Z)-2-CARBOXY-4,6-DICHLOROINDOLE-3-(2'-PHENYL-2'-CARBOXY)-ENE
- Product Name
- (Z)-2-CARBOXY-4,6-DICHLOROINDOLE-3-(2'-PHENYL-2'-CARBOXY)-ENE
- CAS No.
- 161230-88-2
- Chemical Name
- (Z)-2-CARBOXY-4,6-DICHLOROINDOLE-3-(2'-PHENYL-2'-CARBOXY)-ENE
- Synonyms
- MDL-105212;MDL 105,519;MDL 105,519 >=98% (HPLC), solid;(Z)-2-CARBOXY-4,6-DICHLOROINDOLE-3-(2'-PHENYL-2'-CARBOXY)-ENE;3-[(1E)-2-Carboxy-2-phenylethenyl]-4,6-dichloro-1H-indole-2-carboxylic acid;1H-Indole-2-carboxylic acid, 3-[(1E)-2-carboxy-2-phenylethenyl]-4,6-dichloro-
- CBNumber
- CB8317737
- Molecular Formula
- C18H11Cl2NO4
- Formula Weight
- 376.19
- MOL File
- Mol file
(Z)-2-CARBOXY-4,6-DICHLOROINDOLE-3-(2'-PHENYL-2'-CARBOXY)-ENE Property
- Boiling point:
- 601.3±55.0 °C(Predicted)
- Density
- 1.594±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 5 mg/mL
- pka
- 3.20±0.19(Predicted)
- form
- solid
- color
- white
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- M216
- Product name
- MDL 105,519
- Purity
- ≥98% (HPLC), solid
- Packaging
- 5mg
- Price
- $653.6
- Updated
- 2025/07/31
- Product number
- M216
- Product name
- MDL 105,519
- Purity
- ≥98% (HPLC), solid
- Packaging
- 25mg
- Price
- $2760
- Updated
- 2025/07/31
- Product number
- CS-3882
- Product name
- MDL 105,519
- Purity
- 97.15%
- Packaging
- 50mg
- Price
- $1980
- Updated
- 2021/12/16
- Product number
- CS-3882
- Product name
- MDL 105,519
- Purity
- 97.15%
- Packaging
- 5mg
- Price
- $420
- Updated
- 2021/12/16
- Product number
- FC65085
- Product name
- MDL 105519
- Packaging
- 50mg
- Price
- $438
- Updated
- 2021/12/16
(Z)-2-CARBOXY-4,6-DICHLOROINDOLE-3-(2'-PHENYL-2'-CARBOXY)-ENE Chemical Properties,Usage,Production
Uses
MDL 105519 is a potent and selective antagonist of glycine binding to the NMDA receptor.
Biochem/physiol Actions
MDL 105,519 is a high affinity N-methyl-D-aspartate (NMDA) glutamate receptor antagonist at the glycine site. It inhibits NMDA-dependent responses.
in vivo
MDL 105519 is an NMDA receptor antagonistin vivo. Intravenously administration of MDL 105519 prevents harmaline-stimulated increases in cerebellar cyclic GMP content, providing biochemical evidence of NMDA receptor antagonism in vivo. This antagonism is associated with anticonvulsant activity in genetically based, chemically induced, and electrically mediated seizure models. Anxiolytic activity is observed in the rat separation-induced vocalization model, but muscle-relaxant activity is apparent at lower doses. Higher doses impair rotorod performance, but are without effect on mesolimbic dopamine turnover or prepulse inhibition of the startle reflex[1].
IC 50
NMDA Receptor
References
[1] Baron BM, et al. Pharmacological characterization of MDL 105,519, an NMDA receptor glycine site antagonist. Eur J Pharmacol. 1997 Apr 4;323(2-3):181-92. DOI:10.1016/s0014-2999(97)00045-9
(Z)-2-CARBOXY-4,6-DICHLOROINDOLE-3-(2'-PHENYL-2'-CARBOXY)-ENE Preparation Products And Raw materials
Raw materials
Preparation Products
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