ChemicalBook > CAS DataBase List > SIMVASTATIN, SODIUM SALT

SIMVASTATIN, SODIUM SALT

Product Name
SIMVASTATIN, SODIUM SALT
CAS No.
101314-97-0
Chemical Name
SIMVASTATIN, SODIUM SALT
Synonyms
Simvastati;Simvasatin Ep Imp A;SIMVASTATIN, SODIUM SALT;FYSMQCWXGBXWLB-VMCZNHHFSA-M;Simvastatin Impurity 1（EP-A）;Simvastatin Acid Sodium Salt;Simvastatin hydroxy acid sodium;Simvastatin Impurity as Sodium Salt;SimvastatinEPImpurityA-d6SodiumSalt;SIMVASTATIN HYDROXY ACID SODIUM SALT
CBNumber
CB8320771
Molecular Formula
C25H41NaO6
Formula Weight
460.59
MOL File
Mol file
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SIMVASTATIN, SODIUM SALT Property

Melting point:
>122°C (dec.)
storage temp. 
Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility 
DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form 
White powder solid.
color 
White to Pale Beige
Stability:
Hygroscopic
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H303May be harmfulif swallowed

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10010345
Product name
Simvastatin (sodium salt)
Purity
≥98%
Packaging
1mg
Price
$36
Updated
2024/03/01
Cayman Chemical
Product number
10010345
Product name
Simvastatin (sodium salt)
Purity
≥98%
Packaging
5mg
Price
$155
Updated
2024/03/01
Cayman Chemical
Product number
10010345
Product name
Simvastatin (sodium salt)
Purity
≥98%
Packaging
10mg
Price
$274
Updated
2024/03/01
Cayman Chemical
Product number
10010345
Product name
Simvastatin (sodium salt)
Purity
≥98%
Packaging
25mg
Price
$595
Updated
2024/03/01
TRC
Product number
S485050
Product name
SimvastatinHydroxyAcidSodiumSalt
Packaging
25mg
Price
$370
Updated
2021/12/16
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SIMVASTATIN, SODIUM SALT Chemical Properties,Usage,Production

Description

Simvastatin is a competitive inhibitor of HMG-CoA reductase (Ki = 0.12 nM). Simvastatin reduces plasma cholesterol levels in rats and dogs when administered at doses of 1.2 and 8 mg/kg, respectively. Simvastatin suppresses TNF-induced NF-κB activation (IC50 = ~13 μM) and potentiates apoptosis in human myeloid leukemia cells. It also inhibits glutathione peroxidase 4 (GPX4) activity, increases malondialdehyde (MDA) levels, and induces ferroptosis in MDA-MB-231 and MCF-7 breast cancer cells. Formulations containing simvastatin have been used in the treatment of dyslipidemias.

Uses

Simvastatin Hydroxy Acid Sodium Salt is a metabolite of Simvastatin (S485000), a synthetic derivative of a fermentation product of Aspergillus terreus. A competitive inhibitor of HMG-CoA reductase. A synthetic analog of Lovastatin. Antilipemic. Simvastatin, the drug, is sold under the trade name Zocor.

in vitro

previous study found that simvastatin could inhibit the incorporation of 14c-acetate to 14c-sterol with an ic50 value of 15 nm in cultured hep g2 cells. in addition, simvastatin was found to be a potent inhibitor of cholesterol synthesis in cultured liver cells, whereas pravastatin inhibited cholesterol synthesis in liver cells only after these cells had been digested by collagenase [1].

in vivo

animal study showd that rats orally dosed with simvastatin had lower plasma cholesterol levels after 4 days of treatment. at the level of 0.02% of the diet, simvastatin lowered plasma cholesterol levels in rats by 64%. moreove, in dogs, simvastatin at a daily oral dosage of 8 mg/kg lower levels of plasma cholesterol. at this dosage, simvastatin was slightly more potent than lovastatin and the levels of plasma cholesterol in these dogs returned to pretreatment levels after stopping the treatment [1].

References

[1] chao, y. ,chen, j.s.,hunt, v.m., et al. lowering of plasma cholesterol levels in animals by lovastatin and simvastatin. european journal of clinical pharmacology 40, s11-s14 (1991).
[2] s martande s, kumari m, pradeep ar, pal singh s, kumar suke d. ncomparative evaluation of efficacy of subgingivally delivered 1.2% atorvastatin and 1.2% simvastatin in the treatment of intrabony defects in chronic periodontitis: a randomized controlled trial. j dent res dent clin dent prospects. 2017 winter;11(1):18-25.

SIMVASTATIN, SODIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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SIMVASTATIN, SODIUM SALT Suppliers

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101314-97-0, SIMVASTATIN, SODIUM SALTRelated Search:

Simvastatin ammonium salt 6'-EXOMETHYLENE SIMVASTATIN Simvastatin SiMvastatin EP IMpurity G AnhydrosiMvastatin Lovastatin Epi Lovastatin SiMvastatin EP IMpurity G Simvastatin Dimer SiMvastatinAcetate Ester Dehydro Simvastatin MONACOLIN J ACETYLSIMVASTATIN SiMvastatin Hydroxy Acid Ethyl Ester Simvastatin Hydroxy Acid Methyl Ester SiMvastatin 4'-Methyl Ether 2′-Ethyl Simvastatin SiMvastatin Methyl Ester

  • SIMVASTATIN HYDROXY ACID SODIUM SALT
  • SIMVASTATIN, SODIUM SALT
  • sodium,(3R,5S)-7-[(1R,2R,6S,8S)-8-(2,2-dimethylbutanoyloxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate
  • Simvastatin hydroxyl acid sodium salt-d6
  • IMp. A (EP) as SodiuM Salt: (3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-[(2,2-DiMethylbutanoyl)oxy]-2,6-diMethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic Acid SodiuM Salt (Tenivastatin SodiuM Salt
  • Simvastatin Impurity as Sodium Salt
  • Simvastati
  • Simvastatin EP Impurity A Sodium Salt
  • FYSMQCWXGBXWLB-VMCZNHHFSA-M
  • Sodium (3R,5R)-7-{(1S,2S,6R,8S,8aR)-8-[(2,2-dimethylbutanoyl)oxy]-2,6-dimethyl-1,2,6,7,8,8a-hexahydro-1-naphthalenyl}-3,5-dihydroxyheptanoate
  • Simvastatin Impurity 1(Simvastatin EP Impurity A)
  • SiMvastatin IMp. A (EP) as SodiuM Salt
  • Simvastatin Impurity 1（EP-A）
  • Simvastatin hydroxy acid sodium
  • Simvasatin EP Impurity A/ Simvasatin Related Compound A (Simvastatin Sodium/ Tenivastatin Sodium)
  • Simvasatin Ep Imp A
  • Simvastatin EP Impurity AQ: What is Simvastatin EP Impurity A Q: What is the CAS Number of Simvastatin EP Impurity A Q: What is the storage condition of Simvastatin EP Impurity A Q: What are the applications of Simvastatin EP Impurity A
  • Simvastatin hydroxyl acid D6 Sodium salt
  • Simvastatin Acid Sodium Salt
  • Simvastatin Impurity A sodium salt（EP）
  • SimvastatinEPImpurityA-d6SodiumSalt
  • Simvastatin Impurity A as Sodium Salt
  • Simvastatin EP Impurity A as Sodium Salt
  • Simvastatin Impurity 1 Sodium Salt(Simvastatin EP Impurity A Sodium Salt)
  • 1-Naphthaleneheptanoic acid,8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-b,d-dihydroxy-2,6-dimethyl-, monosodium salt, [1S-[1a(bS*,dS*),2a,6b,8b,8aa]]-
  • 101314-97-0
  • 12009-77-6
  • C25H39O6Na