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2-(2-Chlorophenyl)glycine

Product Name
2-(2-Chlorophenyl)glycine
CAS No.
88744-36-9
Chemical Name
2-(2-Chlorophenyl)glycine
Synonyms
DL-2-CHLOROPHENYLGLYCINE;2-CHLOROPHENYLGLYCINE;RARECHEM AK ML 0504;2-(2-Chlorophenyl)glycine;2-CHLORO-DL-PHENYLGLYCINE;(±)-2-Chlorophenylglycine;(+/-)-2-CHLOROPHENYLGLYCINE;(+/-)-2-Chlorophenyl glycine;2-(2-Chlorophenyl)glycine >2-(2-Chlorophenyl)-dl-glycine
CBNumber
CB8325761
Molecular Formula
C8H8ClNO2
Formula Weight
185.61
MOL File
88744-36-9.mol
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2-(2-Chlorophenyl)glycine Property

Melting point:
218-220 °C (decomp)
Boiling point:
318.8±32.0 °C(Predicted)
Density 
1.392±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
form 
Powder
pka
1.69±0.10(Predicted)
color 
White to off-white
Sensitive 
Air Sensitive
Major Application
peptide synthesis
InChI
1S/C8H8ClNO2/c9-6-4-2-1-3-5(6)7(10)8(11)12/h1-4,7H,10H2,(H,11,12)
InChIKey
LMIZLNPFTRQPSF-UHFFFAOYSA-N
SMILES
NC(C(O)=O)c1ccccc1Cl
CAS DataBase Reference
88744-36-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26
WGK Germany 
3
F 
10-23
HS Code 
29224985
Storage Class
11 - Combustible Solids
Hazard Classifications
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
C2579
Product name
2-(2-Chlorophenyl)glycine
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$207
Updated
2025/07/31
TCI Chemical
Product number
C2579
Product name
2-(2-Chlorophenyl)glycine
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$458
Updated
2022/04/27
Usbiological
Product number
269435
Product name
DL-2-Chlorophenylglycine
Packaging
10g
Price
$376
Updated
2021/12/16
TRC
Product number
C350550
Product name
2-Chlorophenylglycine
Packaging
250mg
Price
$55
Updated
2021/12/16
Activate Scientific
Product number
AS24124
Product name
2-(2-Chlorophenyl)glycine
Purity
98+%
Packaging
25g
Price
$71
Updated
2021/12/16
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2-(2-Chlorophenyl)glycine Chemical Properties,Usage,Production

Description

2-(2-Chlorophenyl)glycine is a pharmaceutical intermediate ingredient used in the preparation of Clopidogrel hydrogensulfate, an antiplatelet drug used to prevent blood clots.

Uses

2-Chlorophenylglycine is a Glycine.html" class="link-product" target="_blank">Glycine (HY-Y0966) derivative[1].

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

143-33-9

89-98-5

86169-24-6

The general procedure for the synthesis of (R)-2-amino-2-(2-chlorophenyl)acetic acid from sodium cyanide and o-chlorobenzaldehyde was as follows: 2-chlorophenylglycine was prepared according to the method described in Scheme 1. O-chlorobenzaldehyde (2-chlorobenzaldehyde), ammonium bicarbonate (NH4HCO3, 23.7 g) and sodium cyanide (NaCN, 14.7 g) were dissolved in a mixed solvent of 500 ml of methanol and 500 ml of water, and the reaction was stirred for 5 hours at 65-70 °C. Upon completion of the reaction, the solution was concentrated and transferred to an autoclave, where 45% sodium hydroxide (NaOH) solution was added and refluxed at 120°C for 4 hours. After the reaction mixture was cooled, 2 g of activated carbon was added and stirred for 10 minutes for decolorization. The activated carbon was removed by filtration and the pH of the filtrate was adjusted to 7-8 with 50% sulfuric acid (H2SO4). the precipitate was collected by filtration and washed with water to give 27 g (58% yield) of 2-chlorophenylglycine. The product was RS-2-chlorophenylglycine with a specific optical rotation of +0.16 (C=1, 1N HCl) and a melting point of 185.4-186.8 °C. The product was a mixture of RS-2-chlorophenylglycine, RS-2-chlorophenylglycine and RS-2-chlorophenylglycine.

References

[1] Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144. DOI:10.1080/10408398.2012.708368

2-(2-Chlorophenyl)glycine Preparation Products And Raw materials

Raw materials

Preparation Products

Clopidogrel
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2-(2-Chlorophenyl)glycine Suppliers

Americas 1 China 118 Europe 3 Germany 7 India 25 Japan 1 Russia 1 Slovakia 1 Switzerland 1 The Netherlands 1 Ukraine 3 United Kingdom 9 United States 34 Global 205
J & K SCIENTIFIC LTD.
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18210857532; 18210857532
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86-10-82849933
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jkinfo@jkchemical.com
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China
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Meryer (Shanghai) Chemical Technology Co., Ltd.
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4006356688 18621169109
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86-21-61259102
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market03@meryer.com
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TCI (Shanghai) Development Co., Ltd.
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021-67121386
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021-67121385
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Sales-CN@TCIchemicals.com
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Energy Chemical
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021-021-58432009 400-005-6266
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JinYan Chemicals(ShangHai) Co.,Ltd.
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13817811078
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86-021-50426522,50426273
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Shanghai Longsheng chemical Co.,Ltd.
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021-58099652-8005 13585536065
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Shanghai Hanhong Scientific Co.,Ltd.
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021-54306202 13764082696
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info@hanhongsci.com
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China
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Syntechem Co.,Ltd
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Fax
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Tianjin heowns Biochemical Technology Co., Ltd.
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400 638 7771
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sales@heowns.com
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View Lastest Price from 2-(2-Chlorophenyl)glycine manufacturers

Career Henan Chemical Co
Product
AMINO-(2-CHLORO-PHENYL)-ACETIC ACID 88744-36-9
Price
US $3.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2019-07-04

88744-36-9, 2-(2-Chlorophenyl)glycineRelated Search:

AMINO-(2-CHLORO-PHENYL)-ACETIC ACID,DL-2-Chlorophenylglycine/D-Amino-(2-chloro-phenyl)-acetic acid 2-Chlorophenylacetic acid AMINO-(3-CHLORO-PHENYL)-ACETIC ACID,(S)-AMINO-(3-CHLORO-PHENYL)-ACETIC ACID (R)-AMINO-(2-CHLORO-PHENYL)-ACETIC ACID (S)-AMINO-(2-CHLORO-PHENYL)-ACETIC ACID AMINO-(4-CHLORO-PHENYL)-ACETIC ACID,(S)-AMINO-(4-CHLORO-PHENYL)-ACETIC ACID AMINO-(4-CHLORO-PHENYL)-ACETIC ACID N-Boc-amino-(4-chloro-phenyl)-acetic acid AMINO-(4-CHLORO-PHENYL)-ACETIC ACID (R)-AMINO-(4-CHLORO-PHENYL)-ACETIC ACID AMINO-(4-CHLORO-PHENYL)-ACETIC ACID METHYL ESTER AMINO-(2-CHLORO-PHENYL)-ACETIC ACID HCL (S)-AMINO-(2-CHLORO-PHENYL)-ACETIC ACID HYDROCHLORIDE (R)-AMINO-(3-CHLORO-PHENYL)-ACETIC ACID AMINO-(3-CHLORO-PHENYL)-ACETIC ACID HCL 1-(4-Amino-3-chloro-phenyl)-acetic acid (R)-Amino-(2-chloro-phenyl)-acetic acid hydrochloride 1-(4-Amino-2-chloro-phenyl)-acetic acid

  • alpha-Amino-o-chlorophenylacetic acid, 2-(2-Chlorophenyl)glycine
  • 2-(2-Chlorophenyl)glycine
  • (+/-)-2-Chlorophenylglycine >=98.0% (TLC)
  • AMINO-(2-CHLORO-PHENYL)-ACETIC ACID
  • (+/-)-ALPHA-AMINO-2-CHLOROPHENYLACETIC ACID
  • RARECHEM AK ML 0504
  • O-CHLORO-A-AMINOPHENYLACETIC ACID
  • DL-2-CHLOROPHENYLGLYCINE
  • (+/-)-2-CHLOROPHENYLGLYCINE
  • 2-CHLOROPHENYLGLYCINE
  • 2-CHLORO-DL-PHENYLGLYCINE
  • Amino(2-chlorophenyl)acetic acid, 2-Amino-2-(2-chlorophenyl)ethanoic acid
  • Benzeneacetic acid, a-aMino-2-chloro-
  • 2-(2-Chlorophenyl)glycine &gt
  • Benzeneacetic acid, α-amino-2-chloro-
  • 2-amino-2-(2-chloro-3,4,5,6-tetradeuteriophenyl)acetic acid
  • AMINO-(2-CHLORO-PHENYL)-ACETIC ACID USP/EP/BP
  • 2-(2-Chlorophenyl)-dl-glycine
  • α-Amino-2-chlorobenzeneacetic acid
  • (±)-2-Chlorophenylglycine
  • (±)-2-Chlorophenylglycine, CAS 88744-36-9
  • (+/-)-2-Chlorophenyl glycine
  • 88744-36-9
  • Specialty Synthesis
  • Peptide Synthesis
  • Phenylglycine Derivatives
  • Unnatural Amino Acid Derivatives
  • Amino ACIDS SERIES
  • pharmacetical
  • Benzene series