ChemicalBook > CAS DataBase List > L-2-Chlorophenylglycine

L-2-Chlorophenylglycine

Product Name
L-2-Chlorophenylglycine
CAS No.
141315-50-6
Chemical Name
L-2-Chlorophenylglycine
Synonyms
(R)-2-AMINO-2-(2-CHLOROPHENYL)ACETIC ACID;NSC63256;ST5452327;-(+)-2-(2-ChL;Clopidogrel-10;NCIOpen2_000290;Clopidogrel Impurity 66;Clopidogrel Impurities3;(S)-2-Chorophenylglycine;L-(2-CHLOROPHENYL)GLYCINE
CBNumber
CB1422058
Molecular Formula
C8H8ClNO2
Formula Weight
185.61
MOL File
141315-50-6.mol
More
Less

L-2-Chlorophenylglycine Property

Melting point:
182-187 °C(lit.)
Boiling point:
318.8±32.0 °C(Predicted)
Density 
1.392±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
form 
Solid
pka
1.69±0.10(Predicted)
color 
White to off-white
optical activity
[α]/D 79.0 to 90.0°, c =1 in methanol
[α]20/D +79°, c =1% in chloroform
CAS DataBase Reference
141315-50-6(CAS DataBase Reference)
More
Less

Safety

WGK Germany 
3
HS Code 
2922498590
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
638943
Product name
L-(+)-2-Chlorophenylglycine
Purity
95%
Packaging
5G
Price
$156
Updated
2023/06/20
TCI Chemical
Product number
C2431
Product name
L-(+)-2-(2-Chlorophenyl)glycine
Purity
>98.0%(HPLC)
Packaging
1g
Price
$44
Updated
2021/12/16
TCI Chemical
Product number
C2431
Product name
L-(+)-2-(2-Chlorophenyl)glycine
Purity
>98.0%(HPLC)
Packaging
5g
Price
$132
Updated
2021/12/16
TRC
Product number
C350555
Product name
L-2-Chlorophenylglycine
Packaging
25g
Price
$65
Updated
2021/12/16
Usbiological
Product number
453125
Product name
L-2-Chlorophenylglycine
Packaging
100mg
Price
$305
Updated
2021/12/16
More
Less

L-2-Chlorophenylglycine Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder

Uses

L-2-Chlorophenylglycine

Synthesis

143-33-9

89-98-5

86169-24-6

The general procedure for the synthesis of (R)-2-amino-2-(2-chlorophenyl)acetic acid from sodium cyanide and o-chlorobenzaldehyde is as follows: 2-chlorophenylglycine was prepared according to the synthetic method described in Scheme 1. This was done as follows: 2-chlorobenzaldehyde, ammonium bicarbonate (NH4HCO3; 23.7 g) and sodium cyanide (NaCN; 14.7 g) were dissolved in a mixed solution of 500 ml of methanol and 500 ml of water, and the reaction was stirred for 5 hours at 65-70 °C. Upon completion of the reaction, the solution was concentrated and transferred to an autoclave, where 45% sodium hydroxide (NaOH) solution was added and refluxed at 120°C for 4 hours. After the reaction mixture was cooled, 2 g of activated carbon was added and stirred for 10 minutes for decolorization. The activated carbon was removed by filtration and the pH of the filtrate was adjusted to 7-8 with 50% sulfuric acid (H2SO4).Subsequently, the precipitate was collected by filtration and washed with distilled water to give a final product of 27 g (58% yield) of 2-chlorophenylglycine. The compound had a specific optical rotation of +0.16 (C=1, 1N HCl) and a melting point of 185.4-186.8 °C.

References

[1] Patent: US2004/176637, 2004, A1. Location in patent: Page 3

L-2-Chlorophenylglycine Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

L-2-Chlorophenylglycine Suppliers

Americas 1 China 202 Europe 2 Germany 3 India 3 Slovakia 1 Switzerland 1 United Kingdom 9 United States 36 Global 258
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3572
Advantage
66
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
ShangHai DEMO Chemical Co.,Ltd
Tel
400-021-7337 2355568890
Fax
0086-21-50182339
Email
sales@demochem.com
Country
China
ProdList
2572
Advantage
57
Beijing HwrkChemical Technology Co., Ltd
Tel
18515581800 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
9400
Advantage
55
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
Advantage
66
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9310
Advantage
66
More
Less

View Lastest Price from L-2-Chlorophenylglycine manufacturers

Career Henan Chemical Co
Product
L-2-Chlorophenylglycine 141315-50-6
Price
US $1.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
100KG
Release date
2018-12-21

141315-50-6, L-2-ChlorophenylglycineRelated Search:

2-Chlorobenzoyl chloride 2-(2-Chlorophenyl)acetonitrile 2-Chlorophenol Glycine 2'-Chloroacetophenone Sodium glycinate ALTRENOGEST 2-Chlorobenzonitrile 2-Chlorobenzaldehyde L-Phenylglycine 4-Hydroxy-D-(-)-2-phenylglycine 2-Chlorobenzoic acid Ethyl 2-(Chlorosulfonyl)acetate 6-Aminocaproic acid 4-Aminophenylacetic acid α-Lipoic Acid D-2-Phenylglycine Sodium hydroxymethylglycinate

  • (S)-AMINO-(2-CHLORO-PHENYL)-ACETIC ACID
  • (S)-(+)-ALPHA-AMINO-(2-CHLOROPHENYL)ACETIC ACID
  • (S)-(+)-A-AMINO-(2-CHLOROPHENYL)ACETIC ACID
  • (S)-(+)-2-CHLOROPHENYLGLYCINE
  • S-(+)-2-(2-CHLORO PHENYL)GLYCINE
  • L-(+)-2-CHLOROPHENYLGLYCINE
  • L-(2-CHLOROPHENYL)GLYCINE
  • (L)-(-)-ALPHA-AMINO-(2-CHLOROPHENYL)ACETIC ACID
  • (S)-(+)-(o-Chlorophenyl)glycine
  • 1-(+)-2-chlorophenylglycine
  • (2S)-amino(2-chlorophenyl)ethanoic acid
  • L(+)-O-CHLOROPHENYLGLYCINE
  • Amino chlorophenyl acetic acid
  • (S)-2-Chorophenylglycine
  • (S)-2-Chlorophenylglycinol
  • L-(+)-2-Chlorophenylglycine,(S)-αAmino-(2-chlorophenyl)acetic acid, L-2-Chlorophenylglycine
  • L-(+)-chlorophenyl glycine
  • L-(+)-2-(2-Chlorophenyl)glycine
  • (R)-2-AMINO-2-(2-CHLOROPHENYL)ACETIC ACID
  • (S)-α-Amino-(2-chlorophenyl)acetic acid, L-2-Chlorophenylglycine
  • Clopidogrel-10
  • (+)-2-Chloro-L-phenylglycine, 95%
  • L-2-Chlorophenylglycine (S)-alpha-Amino-(2-chlorophenyl)acetic acid
  • Benzeneacetic acid, .alpha.-amino-2-chloro-, (.alpha.S)-
  • Benzeneacetic acid, a-amino-2-chloro-, (aS)-
  • L-(+)-2-Chlorophenylglycine 95%
  • 2-[(2-chlorophenyl)amino]ethanoic acid
  • N-(2-chlorophenyl)glycine
  • NCIOpen2_000290
  • NSC63256
  • ST5452327
  • <small>L</small>-(+)-2-(2-Chlorophenyl)glycine
  • Benzeneacetic acid, α-amino-2-chloro-, (αS)-
  • (2S)-2-azaniumyl-2-(2-chlorophenyl)acetate
  • Clopidogrel Impurity 66
  • L-(+)-2-(2-Chlorophenyl)glycine &gt
  • (+)-2-Chloro-L-phenylglycine
  • -(+)-2-(2-ChL
  • (S)-2-Amino-2-(2-chlorophenyl)aceticaci
  • 2-Chloro-L-(+)-2-phenylglycine
  • L-2-Chlorophenylglycine USP/EP/BP
  • (S)-2-Amino-2-(2-chlorophenyl)acetic acid (Clopidogrel Impurity)
  • Clopidogrel Impurities192
  • Clopidogrel Impurities3
  • Clopidogrel EP Impurity 26
  • <sc>L</sc>-(+)-2-Chlorophenylglycine
  • 141315-50-6
  • ClC6H4CHNH2CO2H
  • C8ClH8NO2
  • C9H8INO2
  • Carboxylic acid
  • Peptide Synthesis
  • Phenylglycine Derivatives
  • Specialty Synthesis
  • Unnatural Amino Acid Derivatives
  • Amino ACIDS SERIES
  • pharmacetical
  • chiral